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FASLG and SH3GL3
Number of citations of the paper that reports this interaction (PubMedID
19807924
)
40
Data Source:
BioGRID
(unspecified method)
FASLG
SH3GL3
Description
Fas ligand
SH3 domain containing GRB2 like 3, endophilin A3
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Lysosome
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Perinuclear Region Of Cytoplasm
Cytoplasmic Vesicle Lumen
Extracellular Exosome
Acrosomal Vesicle
Cytoplasm
Endosome
Early Endosome
Membrane
Early Endosome Membrane
Presynapse
Postsynaptic Endosome
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Molecular Function
Signaling Receptor Binding
Death Receptor Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Protein Binding
Lipid Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Inflammatory Cell Apoptotic Process
Immune Response
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Angiogenesis
Intracellular Chloride Ion Homeostasis
Response To Lipopolysaccharide
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Retinal Cell Programmed Cell Death
Endosomal Lumen Acidification
T Cell Apoptotic Process
Necroptotic Process
Response To Growth Factor
Cellular Response To Type II Interferon
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Necroptotic Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum
Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Endocytosis
Signal Transduction
Central Nervous System Development
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Clathrin-dependent Endocytosis
Regulation Of Clathrin-dependent Endocytosis
Pathways
Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Interleukin-4 and Interleukin-13 signaling
Dimerization of procaspase-8
FasL/ CD95L signaling
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
FOXO-mediated transcription of cell death genes
TNFs bind their physiological receptors
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
NGF-stimulated transcription
Drugs
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic sensitization (
30013184
)
Asthma (
30929738
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
24999842
25920553
20190752
)
Crohn's disease (
21102463
23128233
)
Daytime sleep phenotypes (
27126917
)
Itch intensity from mosquito bite (
28199695
)
Psoriasis (
28537254
)
Systemic lupus erythematosus (
28714469
)
Type 1 diabetes (
34127860
)
Vitiligo (
27723757
)
A body shape index (
34021172
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) (
30920136
)
FEV1 (
30804560
)
Gynecologic disease (multivariate analysis) (
31488892
)
Height (
18391951
28552196
25282103
20397748
18391950
)
Hip circumference adjusted for BMI (
28552196
34021172
)
Hip index (
34021172
)
Lung function (FEV1/FVC) (
28166213
30804560
)
Proteinuria and chronic kidney disease (
26420894
)
Smoking initiation (
33082346
)
Spine bone size (
31053729
)
Waist circumference adjusted for body mass index (
34021172
)
Working memory (
31598132
)
Interacting Genes
82 interacting genes:
APBB1
ARHGAP9
BAIAP2L1
BTK
CACNB3
CACNB4
CRK
CYSRT1
DAXX
DLG2
DMD
DNMBP
DOCK4
ECM1
EPS8L3
EZR
FADD
FAS
FGR
FN1
FNBP1
FYB1
FYN
GRAP
GRAP2
GRB2
HCK
IHO1
ITK
ITSN2
KALRN
KMT2A
KRT33B
KRT40
KRTAP11-1
KRTAP12-3
LCK
LYN
MACC1
MIA
MMP7
MPP4
MYO15A
NCF1
NCK1
NCK2
NCKIPSD
NOTCH2NLA
OSTF1
PACSIN2
PDCD6
PIK3CA
PIK3R1
PIN1
PPIAP11
PRPF40A
PSTPIP1
PTPN13
RGS20
RIMBP3C
SAMSN1
SEC23A
SH3GL3
SH3PXD2A
SH3PXD2B
SH3RF2
SKAP2
SNX33
SNX9
SORBS3
SPTA1
SRC
SRGAP1
SRGAP2
SRGAP3
SUMO1
TEC
TJP3
TNFRSF6B
TNS2
TRIP6
YES1
52 interacting genes:
ADRB1
ANTKMT
ARHGDIA
ARHGEF6
ATXN2
C11orf68
C4orf17
CALCOCO1
CBLC
CD101
CRIP1
DNAJC5
DNM1
DPPA4
DPYSL4
EGFL6
EGFR
EMD
FASLG
FBXO32
GABBR2
GOLT1B
HTT
LRRK2
NDUFB9
PDCD6IP
PIAS4
PTPRO
QTRT1
RABAC1
RBM48
RER1
RNF8
RPL35A
SEPTIN8
SH3D19
SH3GL1
SH3GL2
SH3KBP1
SHANK3
SHC3
SNRPN
SNX24
SYNJ1
TERF1
TLE5
TMEM120B
TNNT1
TOE1
VIM
WASL
WDR33
Entrez ID
356
6457
HPRD ID
00610
04528
Ensembl ID
ENSG00000117560
ENSG00000140600
Uniprot IDs
P48023
Q53ZZ1
Q99963
PDB IDs
4MSV
5L19
5L36
2EW3
2Z0V
Enriched GO Terms of Interacting Partners
?
Phosphotyrosine Residue Binding
Non-membrane Spanning Protein Tyrosine Kinase Activity
Cytosol
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Signal Transduction
Antigen Receptor-mediated Signaling Pathway
Immune Response-activating Signaling Pathway
Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
T Cell Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Activation Of Immune Response
Regulation Of Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Plasma Membrane
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Regulation Of Cellular Component Organization
Cytoplasm
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Ephrin Receptor Binding
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of Immune System Process
Positive Regulation Of Immune Response
Regulation Of Cell Shape
Regulation Of Cell Morphogenesis
Negative Regulation Of Immune System Process
Regulation Of Actin Filament-based Process
Positive Regulation Of Immune System Process
T Cell Costimulation
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Actin Filament Polymerization
Regulation Of Signal Transduction
Developmental Process
Phospholipase Activator Activity
Endocytosis
B Cell Receptor Signaling Pathway
Regulation Of Cell Motility
Immune System Process
Regulation Of Cell Activation
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Actin Polymerization Or Depolymerization
Anchoring Junction
Positive Regulation Of T Cell Activation
Presynapse
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of CAMKK-AMPK Signaling Cascade
Presynaptic Cytosol
Central Nervous System Development
Cytoplasmic Side Of Mitochondrial Outer Membrane
Cytoplasm
Negative Regulation Of ERBB Signaling Pathway
Cytoplasmic Vesicle
Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides
Vocal Learning
Observational Learning
Synapse
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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