FASLG and RGS20

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FASLG	RGS20
Gene Name		Fas ligand (TNF superfamily, member 6)	regulator of G-protein signaling 20
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Membrane-bounded Vesicle Lumen Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway	Signaling by GPCR GPCR downstream signaling G alpha (z) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 21102463 23128233)
Protein-Protein Interactions		74 interactors: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NL OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1	33 interactors: ADRB2 AQP1 CATSPER1 CRCT1 CREB5 FASLG GLRX3 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HOXA1 HSPD1 INS KIF1A KLHL38 KRTAP4-2 KRTAP5-6 KRTAP5-9 LCE1B LCE2A LCE2D LCE3E LCE4A MAPKBP1 OSTM1 OTX1 PTGER3 PTPMT1 PVRL3 STMN2 TBC1D16
Entrez ID		356	8601
HPRD ID		00610	06225
Ensembl ID		ENSG00000117560	ENSG00000147509
Uniprot IDs		P48023 Q53ZZ1	H9NIM5 O76081
PDB IDs		1BZI
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune System Process Regulation Of Immune System Process Regulation Of Cell Activation Endocytosis Positive Regulation Of Cell Activation Immune Response Regulation Of Cellular Process T Cell Receptor Signaling Pathway Axon Guidance Regulation Of Lymphocyte Activation Signal Transduction Locomotion Positive Regulation Of T Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Defense Response Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-cell Adhesion Signaling Regulation Of Signal Transduction Cell Communication Chemotaxis T Cell Costimulation Axonogenesis Response To External Stimulus Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Axon Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Vesicle-mediated Transport Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Keratinization Keratinocyte Differentiation Epidermis Development Developmental Process Epidermal Cell Differentiation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Organ Development System Development Multicellular Organismal Development Anatomical Structure Development Skin Development Heat Generation G-protein Coupled Receptor Signaling Pathway Cell Differentiation Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Tissue Development Regulation Of CAMP Biosynthetic Process Epithelium Development Regulation Of CAMP Metabolic Process Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Epithelial Cell Differentiation Temperature Homeostasis Membrane Fusion Regulation Of Body Fluid Levels Cell-cell Signaling Negative Regulation Of CAMP Biosynthetic Process Sensory Organ Development Wound Healing Bicarbonate Transport Negative Regulation Of CAMP Metabolic Process Eye Morphogenesis Cell Activation Negative Regulation Of Nucleotide Metabolic Process Acute-phase Response Regulation Of Catalytic Activity Response To Wounding Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Abducens Nerve Formation B Cell Cytokine Production Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport Optokinetic Behavior Isotype Switching To IgG Isotypes Anion Homeostasis
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable
Tagcloud (Intersection) ?