FASLG and CACNB4

Number of citations of the paper that reports this interaction (PMID 19807924)
2

Data Source:
BioGRID (unspecified method)

		FASLG	CACNB4
Gene Name		Fas ligand (TNF superfamily, member 6)	calcium channel, voltage-dependent, beta 4 subunit
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Membrane-bounded Vesicle Lumen Extracellular Vesicular Exosome	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Synapse
	Molecular Function	Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Transport Cellular Calcium Ion Homeostasis Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Axon Guidance Neuromuscular Junction Development Adult Walking Behavior Gamma-aminobutyric Acid Secretion Neuronal Action Potential Propagation Synaptic Transmission, Glutamatergic CAMP Metabolic Process Spleen Development Thymus Development Peyer's Patch Development Muscle Fiber Development T Cell Receptor Signaling Pathway Detection Of Light Stimulus Involved In Visual Perception Membrane Depolarization Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway	NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 21102463 23128233)
Protein-Protein Interactions		74 interactors: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NL OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1	9 interactors: CACNA1A CBX3 FASLG MAP1A MED31 PTN REM1 SYT1 TBL3
Entrez ID		356	785
HPRD ID		00610	09057
Ensembl ID		ENSG00000117560	ENSG00000182389
Uniprot IDs		P48023 Q53ZZ1	E7DBM8 O00305
PDB IDs		1BZI	1VYV 2D46
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune System Process Regulation Of Immune System Process Regulation Of Cell Activation Endocytosis Positive Regulation Of Cell Activation Immune Response Regulation Of Cellular Process T Cell Receptor Signaling Pathway Axon Guidance Regulation Of Lymphocyte Activation Signal Transduction Locomotion Positive Regulation Of T Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Defense Response Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-cell Adhesion Signaling Regulation Of Signal Transduction Cell Communication Chemotaxis T Cell Costimulation Axonogenesis Response To External Stimulus Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Axon Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Vesicle-mediated Transport Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway	Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Chloride Ion Homeostasis Anion Homeostasis Regulation Of Calcium Ion-dependent Exocytosis Acid Secretion Cerebellar Molecular Layer Development Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Neurotransmitter Secretion Vestibular Nucleus Development Cerebellum Maturation G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Musculoskeletal Movement, Spinal Reflex Action Endosomal Lumen Acidification Regulation Of Neurotransmitter Levels Regulation Of Exocytosis Retinal Cell Programmed Cell Death Gamma-aminobutyric Acid Secretion Amino Acid Transport Neurotransmitter Transport Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Necroptotic Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Inflammatory Cell Apoptotic Process Gamma-aminobutyric Acid Transport Regulation Of Neuron Apoptotic Process Cell-cell Signaling Positive Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Hormone Biosynthetic Process Detection Of Calcium Ion Pons Development Regulation Of Neuron Death Positive Regulation Of Calcium Ion-dependent Exocytosis Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Cerebellar Purkinje Cell Differentiation Exocytosis T Cell Apoptotic Process Cerebellar Purkinje Cell Layer Morphogenesis Positive Regulation Of Vesicle Fusion Signaling Neurological System Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Intracellular PH Reduction Cell Communication Regulation Of Vesicle-mediated Transport Reflex PH Reduction
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	altering concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a ppp2r5 ppp2r5d prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	altering concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a ppp2r5 ppp2r5d prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage
Tagcloud (Intersection) ?