FASLG and NCF1

Number of citations of the paper that reports this interaction (PMID 19807924)
2

Data Source:
BioGRID (unspecified method)

		FASLG	NCF1
Gene Name		Fas ligand (TNF superfamily, member 6)	neutrophil cytosolic factor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Membrane-bounded Vesicle Lumen Extracellular Vesicular Exosome	Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Binding Electron Carrier Activity Superoxide-generating NADPH Oxidase Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Response To Yeast Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Respiratory Burst Involved In Defense Response Protein Targeting To Membrane Leukotriene Metabolic Process Superoxide Metabolic Process Apoptotic Process Inflammatory Response Cellular Defense Response Cell Proliferation Superoxide Anion Generation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Respiratory Burst Negative Regulation Of Smooth Muscle Contraction Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Interaction With Host Oxidation-reduction Process Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Phagosome Maturation
Pathways		Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway	Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 21102463 23128233)
Protein-Protein Interactions		74 interactors: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NL OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1	23 interactors: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF4 NOXA1 PRKCA PRKCB PRKCD PRKCZ PRKDC SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		356	653361
HPRD ID		00610
Ensembl ID		ENSG00000117560	ENSG00000158517
Uniprot IDs		P48023 Q53ZZ1	P14598
PDB IDs		1BZI	1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune System Process Regulation Of Immune System Process Regulation Of Cell Activation Endocytosis Positive Regulation Of Cell Activation Immune Response Regulation Of Cellular Process T Cell Receptor Signaling Pathway Axon Guidance Regulation Of Lymphocyte Activation Signal Transduction Locomotion Positive Regulation Of T Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Defense Response Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-cell Adhesion Signaling Regulation Of Signal Transduction Cell Communication Chemotaxis T Cell Costimulation Axonogenesis Response To External Stimulus Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Axon Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Vesicle-mediated Transport Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway	Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Histone H3-T6 Phosphorylation Platelet Activation Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Peptidyl-threonine Phosphorylation Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Immune Response Apoptotic Signaling Pathway Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Phospholipase Activity Cell Death Regulation Of Protein Phosphorylation Death Blood Coagulation Regulation Of Cellular Protein Metabolic Process Hemostasis Cell Surface Receptor Signaling Pathway Regulation Of Phospholipase Activity Cellular Response To Carbohydrate Stimulus Organelle Organization Mitotic Cell Cycle Positive Regulation Of Lipase Activity Response To Interleukin-1 Innate Immune Response Regulation Of Glucose Transport Regulation Of Platelet Aggregation Regulation Of Protein Metabolic Process Muscle System Process Negative Regulation Of Glucose Transport Signaling Regulation Of Phosphorylation Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Protein Phosphorylation Peptidyl-serine Phosphorylation
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine
Tagcloud (Intersection) ?