FASLG and CACNB3

Number of citations of the paper that reports this interaction (PMID 19807924)
2

Data Source:
BioGRID (unspecified method)

		FASLG	CACNB3
Gene Name		Fas ligand (TNF superfamily, member 6)	calcium channel, voltage-dependent, beta 3 subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Membrane-bounded Vesicle Lumen Extracellular Vesicular Exosome	Cytosol Voltage-gated Calcium Channel Complex Membrane Apical Plasma Membrane
	Molecular Function	Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Voltage-gated Calcium Channel Activity High Voltage-gated Calcium Channel Activity Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Transport Calcium Ion Transport Synaptic Transmission Axon Guidance Neuromuscular Junction Development T Cell Receptor Signaling Pathway Membrane Depolarization Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses Adrenaline,noradrenaline inhibits insulin secretion
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 21102463 23128233)
Protein-Protein Interactions		74 interactors: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NL OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1	4 interactors: CACNA1B CACNA1C FASLG SYT1
Entrez ID		356	784
HPRD ID		00610	11879
Ensembl ID		ENSG00000117560	ENSG00000167535
Uniprot IDs		P48023 Q53ZZ1	P54284
PDB IDs		1BZI
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune System Process Regulation Of Immune System Process Regulation Of Cell Activation Endocytosis Positive Regulation Of Cell Activation Immune Response Regulation Of Cellular Process T Cell Receptor Signaling Pathway Axon Guidance Regulation Of Lymphocyte Activation Signal Transduction Locomotion Positive Regulation Of T Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Defense Response Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-cell Adhesion Signaling Regulation Of Signal Transduction Cell Communication Chemotaxis T Cell Costimulation Axonogenesis Response To External Stimulus Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Axon Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Vesicle-mediated Transport Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway	Cell-cell Signaling Calcium Ion Import Membrane Depolarization During Action Potential Secretion By Cell Synaptic Transmission Secretion Action Potential Neurotransmitter Secretion Membrane Depolarization Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Neurotransmitter Levels Neurotransmitter Transport Regulation Of Heart Contraction Regulation Of Blood Pressure Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport Smooth Muscle Contraction Involved In Micturition Calcium-mediated Signaling Using Extracellular Calcium Source Endosomal Lumen Acidification Locomotory Behavior Retinal Cell Programmed Cell Death Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Membrane Potential Necroptotic Signaling Pathway Calcium Ion Transport Blood Circulation Micturition Exocytosis Cellular Chloride Ion Homeostasis Inflammatory Cell Apoptotic Process Chloride Ion Homeostasis Ion Transport Urinary Bladder Smooth Muscle Contraction Regulation Of Ion Transmembrane Transport Positive Regulation Of Endothelial Cell Apoptotic Process Growth Hormone Secretion Detection Of Calcium Ion Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Cation Homeostasis Cellular Ion Homeostasis Establishment Of Localization In Cell Positive Regulation Of Calcium Ion-dependent Exocytosis Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion T Cell Apoptotic Process Cellular Chemical Homeostasis Positive Regulation Of Vesicle Fusion Signaling Ion Homeostasis Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	acinus adapter alg2 casp3 coinduction competing elucidating ercc3 fem1 gadd153 gadd34 gated gsn helps hereditary heretofore igf1 igfbp2 ischemia modules muscular nrp1 oligodeoxynucleotide permits smn1 tfdp1 tiar vim
Tagcloud (Difference) ?		cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	acinus adapter alg2 coinduction competing elucidating ercc3 fem1 gadd153 gadd34 gated gsn helps hereditary heretofore igf1 igfbp2 ischemia modules muscular nrp1 oligodeoxynucleotide permits smn1 tfdp1 tiar vim
Tagcloud (Intersection) ?		casp3