ERBB2 and MET

Number of citations: 49 (PubMedID 30898150)
Data Source: BioGRID (protein complementation assay, affinity chromatography technology, imaging technique, proximity labelling technology)

		ERBB2	MET
Name		erb-b2 receptor tyrosine kinase 2	MET proto-oncogene, receptor tyrosine kinase
Structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Basal Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Neuromuscular Junction Ruffle Membrane ERBB3:ERBB2 Complex Presynaptic Membrane Cell Projection Myelin Sheath Receptor Complex Perinuclear Region Of Cytoplasm	Extracellular Region Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Receptor Complex Postsynapse
	Molecular Function	Nucleotide Binding RNA Polymerase I Core Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Growth Factor Binding Receptor Tyrosine Kinase Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Hepatocyte Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Semaphorin Receptor Activity Protein Phosphatase Binding Identical Protein Binding Molecular Function Activator Activity
	Biological Process	Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Peripheral Nervous System Development Heart Development Neuromuscular Junction Development Motor Neuron Axon Guidance Cell Population Proliferation Positive Regulation Of Gene Expression Schwann Cell Development Peptidyl-tyrosine Phosphorylation Neuron Differentiation Positive Regulation Of Cell Growth Regulation Of Microtubule-based Process Immature T Cell Proliferation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction ERBB2 Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Wound Healing Regulation Of Cell Population Proliferation Myelination Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Translation Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase I Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Semaphorin-plexin Signaling Pathway Positive Regulation Of Protein Targeting To Membrane Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Intracellular Signal Transduction	Endothelial Cell Morphogenesis Liver Development Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Autophagy Neuron Differentiation Pancreas Development Positive Regulation Of Microtubule Polymerization Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Signaling Pathway Cell Development Animal Organ Development Branching Morphogenesis Of An Epithelial Tube Positive Chemotaxis Negative Regulation Of Stress Fiber Assembly Excitatory Postsynaptic Potential Establishment Of Skin Barrier Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Semaphorin-plexin Signaling Pathway Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Signaling by ERBB2 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D induced cell migration and growth-cone collapse RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D mediated inhibition of cell attachment and migration RAF/MAP kinase cascade MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 MECP2 regulates neuronal receptors and channels Drug-mediated inhibition of MET activation Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs		Trastuzumab Lapatinib IGN311 Trastuzumab emtansine Varlitinib AV-412 Pertuzumab Afatinib Tucatinib Tesevatinib Fostamatinib Brigatinib Margetuximab Zanubrutinib	Sunitinib K-252a SGX-523 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol AMG-208 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE Crizotinib Cabozantinib Capmatinib Tivozanib Fostamatinib Tivantinib Brigatinib Amuvatinib Tepotinib Amivantamab
Diseases		Breast cancer Cervical cancer Cholangiocarcinoma Pancreatic cancer Gastric cancer Ovarian cancer Choriocarcinoma Endometrial Cancer Bladder cancer	Cholangiocarcinoma Gastric cancer Renal cell carcinoma
GWAS		Adult asthma ( 30787307 ) Asthma ( 29273806 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Bipolar disorder ( 27329760 34002096 ) Estimated glomerular filtration rate ( 31451708 ) Pancreatic ductal adenocarcinoma ( 30541042 ) Polycystic ovary syndrome ( 26416764 ) Refractive error ( 32231278 ) Systemic lupus erythematosus ( 26502338 28714469 ) Ulcerative colitis ( 20228799 )	Age at first sexual intercourse ( 34211149 ) Alanine aminotransferase levels ( 33547301 ) Blood protein levels ( 30072576 ) Gamma glutamyl transferase levels ( 29403010 33339817 ) HDL cholesterol levels ( 28334899 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Hematocrit ( 28017375 ) Lung function (FEV1/FVC) ( 30804560 ) Medication use (beta blocking agents) ( 31015401 ) Multiple sclerosis (severity) ( 19010793 ) PR segment duration ( 24850809 ) Pulse pressure ( 30578418 ) Resting heart rate ( 27798624 29769521 ) Triglyceride levels ( 28334899 ) Triglycerides ( 24097068 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		347 interacting genes: AATK ABCB5 ABL1 ABL2 ACP1 ACP3 ADGRB1 AIP AKAP12 AKT1 ALDOA ALDOC ALK ANKS1A ANKS1B ANXA6 AP3B2 APBB1 APBB3 ARF1 ARF5 ARNT ASRGL1 ATP6AP1 ATP6V0C AURKA BAAT BCAR3 BECN1 BLK BLNK BMX BNIP1 BTC CACYBP CALM1 CAV1 CBLC CBR1 CCDC180 CCND2 CCT3 CD82 CDK4 CDK6 CDK8 CDKN2B CDKN2C CEND1 CFAP298 CFL1 CHN1 CISH CKB CLASP2 CLCN6 CLNK COL9A2 COL9A3 CRIP2 CRK CRKL CSDE1 CTNNB1 CXCL8 CYLC2 CYP17A1 DAB1 DDR1 DLG4 DOK1 DOK4 DOK6 DST DUSP14 DUSP18 DUSP19 EGF EGFR EPHA1 EPHA3 EPHA4 EPHB1 EPHB3 EPHB6 ERBB3 ERBB4 ERBIN ERG28 ERRFI1 ESR1 FAM241B FBP1 FBXO7 FER FES FGFR1 FGFR2 FGFR3 FGFR4 FGR FKBP1A FKBP3 FKBP8 FLNB FLT3 FLT4 FRAT2 FZR1 GAB1 GABARAPL1 GABARAPL2 GAPDH GLCE GLIS2 GLRX3 GMPR2 GPM6B GRAP2 GRB10 GRB14 GRB2 GRB7 GRK2 GRM1 GSN HCK HDAC6 HDLBP HGF HLA-A HRAS HSD17B3 HSH2D HSP90AA1 HSP90AB1 HSP90B1 HSPA1A HSPA5 HSPA9 HSPD1 IARS1 IGF1R IL13RA2 IL6ST ILF3 ILKAP INPPL1 INSR IRF2BP2 IRS1 IRS4 ITGA5 ITGB4 ITK ITPKA ITPR1 JAK1 JAK2 JMJD4 JUP KCTD6 KDELR2 KLC1 KLK5 LATS2 LCK LCP2 LGALS8 LPCAT4 LRRC7 LYPD3 MAP2K1 MAP2K3 MAP2K5 MAPK8IP1 MAPK8IP2 MATK MDH1 MEPCE MERTK MET MSN MST1R MTCH1 MUC1 MUC4 MUCL1 MYC MYO9A NAT2 NCK1 NCK2 NEFH NF2 NINL NRG1 NTRK1 NTRK2 NTRK3 NUDT16L1 ODF2L PABPC1 PAK1 PARP1 PDCD11 PDGFRA PDGFRB PEBP1 PGAM1 PHF23 PICK1 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 POLD2 POU6F1 PPA1 PPM1A PPM1F PRDM14 PRDX5 PSAP PSMA1 PSMC3 PSMC3IP PSMD3 PTGES3L-AARSD1 PTK2 PTK2B PTK6 PTK7 PTPN11 PTPN18 PTPN6 PTPRR PTPRT PTPRU RAB5C RAF1 RASA1 RASSF1 RBM15B RET RHBDD2 RHOBTB2 RIN1 RIN2 ROR2 RPRML RTN4 S100A11 SAFB2 SELENOK SERPINA3 SFRP4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH2D5 SH3BGRL3 SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SLC7A4 SMAD1 SMIM20 SMPD4 SMURF2 SNAP91 SOCS1 SOCS3 SOCS5 SOCS6 SORL1 SOS1 SPP1 SRC SRPK1 STAP1 STAT3 STIP1 STK11 STK24 STMN1 STMN2 STUB1 STYK1 STYX SUPT6H SYK SYNM TCEAL2 TEC TGFA TGFB1 THRSP TLN1 TMA7 TMEM134 TMEM230 TNS1 TNS2 TNS3 TOB1 TP53 TRIP6 TRMO TSEN15 TTC9B TTYH2 TVP23B TXK TXN TYMP TYRO3 UBB USP2 UTP18 VAPA VAV1 VAV2 VAV3 YES1 YWHAZ ZAP70 ZFAND1 ZMAT2 ZMYND8 ZNF189 ZNF532	112 interacting genes: ABL2 BAG1 BCAR3 BLK BTK CASP3 CBL CCND2 CD44 CDK4 CDK6 CDKN2B CNR1 CRK CTNNB1 CTTN DAPK3 DCN DNAJA3 EGFR EPHA2 ERBB2 FAS FES FGFR4 FGR FZR1 GAB1 GLIS2 GLMN GRB14 GRB2 GRB7 HCK HGF HGS HSH2D INPP5D INPPL1 ITGB1 ITGB4 ITK KDELR2 LATS2 LCK LYN MAP2K3 MAP2K5 MATK MUC20 MYC NCK1 NCK2 NF2 PCBD2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PLXNB1 PTK6 PTPN11 PTPRB PTPRJ RAF1 RANBP10 RANBP9 RASA1 RASSF1 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA2 SMC1A SNAPIN SNX2 SOCS1 SOCS2 SOCS3 SOCS5 SOCS6 SPSB1 SRC STAP1 STAT3 STK11 SYK TEC TERT TNS1 TNS2 TNS3 TNS4 TP53 TXK VAV1 VAV2 VAV3 YES1 ZAP70
Entrez ID		2064	4233
HPRD ID		01281	01280
Ensembl ID		ENSG00000141736	ENSG00000105976
Uniprot IDs		B4DTR1 F5H1T4 J3QLU9 P04626 X5DNK3	B4DLF5 E6Y365 P08581
PDB IDs		1MFG 1MFL 1MW4 1N8Z 1QR1 1S78 2A91 2JWA 2KS1 2L4K 2N2A 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN 4NND 5K33 5KWG 5MY6 5O4G 5OB4 5TQS 6ATT 6BGT 6J71 6LBX 6OGE 7JXH 7MN5 7MN6 7MN8 7PCD 7QVK 8FFJ 8HGO 8HGP 8JYQ 8JYR 8PWH 8Q6J 8U4K 8U4L 8U8X 8VB5 8VQD 8VQE 9L1S	1FYR 1R0P 1R1W 1SHY 1SSL 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ 3EFK 3F66 3F82 3I5N 3L8V 3LQ8 3Q6U 3Q6W 3QTI 3R7O 3RHK 3U6H 3U6I 3VW8 3ZBX 3ZC5 3ZCL 3ZXZ 3ZZE 4AOI 4AP7 4DEG 4DEH 4DEI 4EEV 4GG5 4GG7 4IWD 4K3J 4KNB 4MXC 4O3T 4O3U 4R1V 4R1Y 4XMO 4XYF 5DG5 5EOB 5EYC 5EYD 5HLW 5HNI 5HO6 5HOA 5HOR 5HTI 5LSP 5T3Q 5UAB 5UAD 5YA5 6GCU 6I04 6SD9 6SDC 6SDD 6SDE 6UBW 6WVZ 7B3Q 7B3T 7B3V 7B3W 7B3Z 7B40 7B41 7B42 7B43 7B44 7MO7 7MO8 7MO9 7MOA 7MOB 7V3R 7V3S 7Y4T 7Y4U 8AN8 8ANS 8AU3 8AU5 8AW1 8GVJ 8K78 8OUU 8OUV 8OV7 8OVZ 8OW3 8OWG 9C1R 9IVB
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Signal Transduction Protein Kinase Activity Regulation Of Signal Transduction ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Protein Phosphorylation Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Plasma Membrane ATP Binding Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Motility Cell Migration Positive Regulation Of Locomotion Protein Kinase Binding Intracellular Signaling Cassette Positive Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Regulation Of Cell Motility Phosphate-containing Compound Metabolic Process Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Motility Regulation Of Cell Migration Focal Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Nucleotide Binding	Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell Adhesion Cytosol ERBB Signaling Pathway Immune Response-activating Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Cell Activation Peptidyl-tyrosine Phosphorylation Leukocyte Activation Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Negative Regulation Of Signal Transduction Protein Kinase Activity Lymphocyte Activation Activation Of Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Immune System Process Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Immune System Process Fc Receptor Signaling Pathway Regulation Of Lymphocyte Activation Kinase Activity Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Regulation Of Cell-cell Adhesion Regulation Of MAPK Cascade T Cell Activation