ERBB2 and HSP90B1

Number of citations of the paper that reports this interaction (PMID 8617772)
30

Data Source:
HPRD (in vitro)

		ERBB2	HSP90B1
Gene Name		erb-b2 receptor tyrosine kinase 2	heat shock protein 90kDa beta (Grp94), member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Receptor Complex Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Midbody Extracellular Matrix Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	RNA Polymerase I Core Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Protein C-terminus Binding Growth Factor Binding Protein Phosphatase Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity Protein Dimerization Activity	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Peripheral Nervous System Development Heart Development Neuromuscular Junction Development Motor Neuron Axon Guidance Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Cell Growth Positive Regulation Of Rho GTPase Activity Regulation Of Microtubule-based Process Negative Regulation Of Immature T Cell Proliferation In Thymus Fc-epsilon Receptor Signaling Pathway Wound Healing Myelination Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Translation Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Actin Rod Assembly Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Cellular Protein Metabolic Process Innate Immune Response Sequestering Of Calcium Ion Cellular Response To ATP
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Axon guidance PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse Innate Immune System Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling Signalling by NGF DAP12 interactions GAB1 signalosome Semaphorin interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Scavenging by Class A Receptors ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR) Innate Immune System
Drugs		Trastuzumab Lapatinib ado-trastuzumab emtansine Pertuzumab Afatinib	Rifabutin 2-Chlorodideoxyadenosine 1-Methoxy-2-(2-Methoxyethoxy)Ethane Adenosine-5\'-Diphosphate N-Ethyl-5\'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Diseases
GWAS			Coronary heart disease ( 21626137)
Protein-Protein Interactions		110 interactors: ABL1 ABL2 ACPP ANKS1A ANKS1B APBB1 APBB3 BCAR3 BLK BLNK BMX BTC CAV1 CBL CD82 CHN1 CISH CLNK CRK CRKL CTNNB1 DAB1 DLG4 DOK1 DOK4 DOK6 EGF EGFR ERBB2IP ERBB3 ERBB4 ERRFI1 ESR1 FER FGR GRAP2 GRB2 GRB7 HDAC6 HLA-A HSP90AA1 HSP90B1 IL6ST IRS1 IRS4 ITGA5 ITGB4 ITK JAK1 JAK2 JUP MAPK8IP1 MAPK8IP2 MATK MUC1 MUC4 NCK2 NF2 NRG1 PAK1 PICK1 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PTK2 PTK2B PTPN11 PTPN18 RASA1 RIN1 RIN2 SERPINA3 SH2B2 SH2B3 SH2D1B SH2D2A SH2D3A SH2D5 SH3BGRL3 SH3BP2 SHC1 SHC2 SHC3 SLA SLA2 SOCS1 SOS1 SRC SRPK1 STAT1 STAT3 STUB1 SUPT6H SYK TEC TGFA TLN1 TNS2 TNS3 TOB1 TXK UBB USP2 VAV1 VAV2 VAV3	21 interactors: APOB ASGR1 BIRC2 CCT2 CSNK2A1 CSNK2A2 EGFR ERBB2 FANCC HSPA9 LRP1 MAPK6 MDM2 MTTP NKX3-1 POLR2E TG TLR1 TLR2 TLR4 TXNDC11
Entrez ID		2064	7184
HPRD ID		01281	01860
Ensembl ID		ENSG00000141736	ENSG00000166598
Uniprot IDs		P04626	B4DHT9 P14625
PDB IDs		1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 2KS1 2L4K 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 4GFU
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Communication Signaling Cell Surface Receptor Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Stimulus Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Stimulus Regulation Of Immune Response Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Immune System Process Cellular Response To Organic Substance Regulation Of Kinase Activity Regulation Of Phosphorylation Response To Stress Peptidyl-tyrosine Autophosphorylation Regulation Of Catalytic Activity Response To Organic Substance Cellular Response To Organonitrogen Compound Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Process Cellular Response To Peptide Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Locomotion Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Cell Motility Cell Migration Wound Healing Response To Peptide Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus	Cellular Response To Stimulus Response To External Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Detection Of Molecule Of Bacterial Origin Response To Stimulus Innate Immune Response Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Lipoprotein Transport Cellular Response To Triacyl Bacterial Lipopeptide Detection Of Triacyl Bacterial Lipopeptide Negative Regulation Of Mitotic Cell Cycle Cellular Response To Lipid Detection Of Biotic Stimulus Macrophage Activation Response To Abiotic Stimulus Toll-like Receptor Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Immune System Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Immune Response Cell Communication Response To Stress Positive Regulation Of Nitric Oxide Biosynthetic Process Activation Of Innate Immune Response Cellular Metabolic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immune Response Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Transport Defense Response Cellular Protein Metabolic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Transport Detection Of Bacterial Lipoprotein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Innate Immune Response Regulation Of Establishment Of Protein Localization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Proliferation Regulation Of Mitotic Cell Cycle Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	adaptive attenuates attractive carcinogen ceramides chaperone compensatory controversial cre dena diethyl expansion gp96 grp94 hccs hepatocyte hepatocytes hyperplasia maintains nitrosoamine oncogenesis paralog perturbs pharmacologically predisposes probed recombinase steatotic vital
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	adaptive attenuates attractive carcinogen ceramides chaperone compensatory controversial cre dena diethyl expansion gp96 grp94 hccs hepatocyte hepatocytes hyperplasia maintains nitrosoamine oncogenesis paralog perturbs pharmacologically predisposes probed recombinase steatotic vital
Tagcloud (Intersection) ?