ERBB2 and PSMA1

Number of citations of the paper that reports this interaction (PubMedID 31980649)
68

Data Source:
BioGRID (two hybrid)

		ERBB2	PSMA1
Description		erb-b2 receptor tyrosine kinase 2	proteasome 20S subunit alpha 1
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GO Annotations	Cellular Component	Semaphorin Receptor Complex Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Basal Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Neuromuscular Junction Ruffle Membrane ERBB3:ERBB2 Complex Presynaptic Membrane Cell Projection Myelin Sheath Receptor Complex Perinuclear Region Of Cytoplasm	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Proteasome Core Complex Proteasome Core Complex, Alpha-subunit Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding RNA Polymerase I Core Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Growth Factor Binding Receptor Tyrosine Kinase Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity	Lipopolysaccharide Binding Protein Binding
	Biological Process	Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Peripheral Nervous System Development Heart Development Neuromuscular Junction Development Motor Neuron Axon Guidance Cell Population Proliferation Positive Regulation Of Gene Expression Schwann Cell Development Peptidyl-tyrosine Phosphorylation Neuron Differentiation Positive Regulation Of Cell Growth Regulation Of Microtubule-based Process Immature T Cell Proliferation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction ERBB2 Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Wound Healing Regulation Of Cell Population Proliferation Myelination Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Translation Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase I Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Semaphorin-plexin Signaling Pathway Positive Regulation Of Protein Targeting To Membrane Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Intracellular Signal Transduction	Immune System Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process
Pathways		Signaling by ERBB2 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D induced cell migration and growth-cone collapse RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs		Trastuzumab Lapatinib IGN311 Trastuzumab emtansine Varlitinib AV-412 Pertuzumab Afatinib Tucatinib Tesevatinib Fostamatinib Brigatinib Margetuximab Zanubrutinib	(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases		Breast cancer Cervical cancer Cholangiocarcinoma Pancreatic cancer Gastric cancer Ovarian cancer Choriocarcinoma Endometrial Cancer Bladder cancer
GWAS		Adult asthma ( 30787307) Asthma ( 29273806 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 27329760 34002096) Estimated glomerular filtration rate ( 31451708) Pancreatic ductal adenocarcinoma ( 30541042) Polycystic ovary syndrome ( 26416764) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338 28714469) Ulcerative colitis ( 20228799)	Alzheimer's disease (cognitive decline) ( 23535033) Bipolar disorder ( 31043756) Diastolic blood pressure ( 27841878) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32203549) High chromosomal aberration frequency (total) ( 31586183) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Skin and soft tissue infections ( 33662382) Systolic blood pressure ( 27841878) Triglyceride levels ( 32154731 32203549) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		347 interacting genes: AATK ABCB5 ABL1 ABL2 ACP1 ACP3 ADGRB1 AIP AKAP12 AKT1 ALDOA ALDOC ALK ANKS1A ANKS1B ANXA6 AP3B2 APBB1 APBB3 ARF1 ARF5 ARNT ASRGL1 ATP6AP1 ATP6V0C AURKA BAAT BCAR3 BECN1 BLK BLNK BMX BNIP1 BTC CACYBP CALM1 CAV1 CBLC CBR1 CCDC180 CCND2 CCT3 CD82 CDK4 CDK6 CDK8 CDKN2B CDKN2C CEND1 CFAP298 CFL1 CHN1 CISH CKB CLASP2 CLCN6 CLNK COL9A2 COL9A3 CRIP2 CRK CRKL CSDE1 CTNNB1 CXCL8 CYLC2 CYP17A1 DAB1 DDR1 DLG4 DOK1 DOK4 DOK6 DST DUSP14 DUSP18 DUSP19 EGF EGFR EPHA1 EPHA3 EPHA4 EPHB1 EPHB3 EPHB6 ERBB3 ERBB4 ERBIN ERG28 ERRFI1 ESR1 FAM241B FBP1 FBXO7 FER FES FGFR1 FGFR2 FGFR3 FGFR4 FGR FKBP1A FKBP3 FKBP8 FLNB FLT3 FLT4 FRAT2 FZR1 GAB1 GABARAPL1 GABARAPL2 GAPDH GLCE GLIS2 GLRX3 GMPR2 GPM6B GRAP2 GRB10 GRB14 GRB2 GRB7 GRK2 GRM1 GSN HCK HDAC6 HDLBP HGF HLA-A HRAS HSD17B3 HSH2D HSP90AA1 HSP90AB1 HSP90B1 HSPA1A HSPA5 HSPA9 HSPD1 IARS1 IGF1R IL13RA2 IL6ST ILF3 ILKAP INPPL1 INSR IRF2BP2 IRS1 IRS4 ITGA5 ITGB4 ITK ITPKA ITPR1 JAK1 JAK2 JMJD4 JUP KCTD6 KDELR2 KLC1 KLK5 LATS2 LCK LCP2 LGALS8 LPCAT4 LRRC7 LYPD3 MAP2K1 MAP2K3 MAP2K5 MAPK8IP1 MAPK8IP2 MATK MDH1 MEPCE MERTK MET MSN MST1R MTCH1 MUC1 MUC4 MUCL1 MYC MYO9A NAT2 NCK1 NCK2 NEFH NF2 NINL NRG1 NTRK1 NTRK2 NTRK3 NUDT16L1 ODF2L PABPC1 PAK1 PARP1 PDCD11 PDGFRA PDGFRB PEBP1 PGAM1 PHF23 PICK1 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 POLD2 POU6F1 PPA1 PPM1A PPM1F PRDM14 PRDX5 PSAP PSMA1 PSMC3 PSMC3IP PSMD3 PTGES3L-AARSD1 PTK2 PTK2B PTK6 PTK7 PTPN11 PTPN18 PTPN6 PTPRR PTPRT PTPRU RAB5C RAF1 RASA1 RASSF1 RBM15B RET RHBDD2 RHOBTB2 RIN1 RIN2 ROR2 RPRML RTN4 S100A11 SAFB2 SELENOK SERPINA3 SFRP4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH2D5 SH3BGRL3 SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SLC7A4 SMAD1 SMIM20 SMPD4 SMURF2 SNAP91 SOCS1 SOCS3 SOCS5 SOCS6 SORL1 SOS1 SPP1 SRC SRPK1 STAP1 STAT3 STIP1 STK11 STK24 STMN1 STMN2 STUB1 STYK1 STYX SUPT6H SYK SYNM TCEAL2 TEC TGFA TGFB1 THRSP TLN1 TMA7 TMEM134 TMEM230 TNS1 TNS2 TNS3 TOB1 TP53 TRIP6 TRMO TSEN15 TTC9B TTYH2 TVP23B TXK TXN TYMP TYRO3 UBB USP2 UTP18 VAPA VAV1 VAV2 VAV3 YES1 YWHAZ ZAP70 ZFAND1 ZMAT2 ZMYND8 ZNF189 ZNF532	173 interacting genes: ABCD3 ABI2 ABI3 ACTN1 ACTN2 AGR2 APIP APP BANF2 BLZF1 C22orf39 CABP5 CALCOCO2 CBS CCDC102B CCDC136 CCDC85B CCNH CDA CDKN2D CDR2 CEBPA CEP70 CEP72 CFAP206 CHMP1A CINP CIP2A COG4 COG6 COIL CRX CSTPP1 DCTD DCTPP1 DDIT4L DEF6 DLEU1 DRC12 DYDC1 DYNLT1 EHMT2 EIF4A3 EMSY ERBB2 FNDC11 GNPTAB GOLGA2 GOLGA6A GPHN GSDMD GUCD1 HEXIM2 HOMER3 HOMEZ HOOK2 HOXC11 HSD17B14 HSF2BP IFT20 IKZF1 IKZF3 INO80E IPO13 KAZN KCTD1 KCTD13 KCTD17 KCTD6 KCTD7 KCTD9 KHDRBS3 KRT13 KRT15 KRT19 KRT31 KRT34 KRT37 KRT38 KRT40 KRTAP1-1 KRTAP1-3 KRTAP4-1 KRTAP5-9 KRTAP6-3 LDB1 LDOC1 LINC00632 LMO2 LONRF1 LZTFL1 LZTS1 LZTS2 MAD1L1 MAPK1 MAPRE1 MAPRE3 MCM6 MDH2 MID2 MIEF1 MKNK2 MKRN3 MLH1 MRFAP1L1 MSANTD4 MT-CO2 MTUS2 NAB2 NBPF19 NECAB2 NME7 NMI NOP53 NOTCH2NLA PCBD1 PCYT2 PICK1 PLK1 PM20D2 PNMA1 PNMA2 PNMA5 POLR1C PPCDC PRDM14 PRIMPOL PRKN PRPH PSMA2 PSMA3 PSMA4 PSMA7 PSMB10 PSMB2 PSMB5 RAD54B RBCK1 REL RFC2 RGS19 ROPN1 SAT1 SFMBT1 SH3BP4 SH3GLB1 SLF2 SNCA SPDEF SSX2IP TCF12 TCF4 TDO2 TEKT4 TNFAIP1 TNR TRAF1 TRAF5 TRIM10 TRIM23 TRIM27 TRIM42 TRIM54 TSC22D4 UBD UBXN11 VCP VIM VMAC WTAP YPEL5 ZFAND1 ZMYND19
Entrez ID		2064	5682
HPRD ID		01281	04170
Ensembl ID		ENSG00000141736	ENSG00000129084
Uniprot IDs		B4DTR1 F5H1T4 J3QLU9 P04626 X5DNK3	B4E0X6 P25786
PDB IDs		1MFG 1MFL 1MW4 1N8Z 1QR1 1S78 2A91 2JWA 2KS1 2L4K 2N2A 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN 4NND 5K33 5KWG 5MY6 5O4G 5OB4 5TQS 6ATT 6BGT 6J71 6LBX 6OGE 7JXH 7MN5 7MN6 7MN8 7PCD 7QVK 8FFJ 8HGO 8HGP 8JYQ 8JYR 8PWH 8Q6J 8U4K 8U4L 8U8X 8VB5 8VQD 8VQE 9L1S	4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ 7AWE 7B12 7LXV 7NAN 7NAO 7NAP 7NAQ 7NHT 7PG9 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7V5G 7V5M 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8BZL 8CVR 8CVS 8CVT 8CXB 8JRI 8JRT 8JTI 8K0G 8QYJ 8QYL 8QYM 8QYN 8QYO 8QYS 8QZ9 8TM3 8TM4 8TM5 8TM6 8UD9 8USB 8USC 8YIX 8YIY 8YIZ 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q 9HMN
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Signal Transduction Protein Kinase Activity Regulation Of Signal Transduction ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Protein Phosphorylation Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Plasma Membrane ATP Binding Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Motility Cell Migration Positive Regulation Of Locomotion Protein Kinase Binding Intracellular Signaling Cassette Positive Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Regulation Of Cell Motility Phosphate-containing Compound Metabolic Process Regulation Of Locomotion Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Motility Regulation Of Cell Migration Focal Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Nucleotide Binding	Identical Protein Binding Protein Binding Cytoskeleton Intermediate Filament Proteasome Core Complex Keratin Filament Intermediate Filament Organization Structural Constituent Of Skin Epidermis Cytoplasm Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Proteasome Complex Cytosol Protein Homooligomerization Proteasome Core Complex, Alpha-subunit Complex Protein Complex Oligomerization Cytoskeleton Organization Protein Domain Specific Binding Aggresome Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Serine/threonine Kinase Binding Regulation Of Microtubule-based Process Inclusion Body Assembly Cytosine Metabolic Process Structural Molecule Activity Positive Regulation Of Protein K63-linked Deubiquitination Cullin Family Protein Binding Nucleus Proteasome Core Complex, Beta-subunit Complex Microtubule-based Process Positive Regulation Of Organelle Organization Ficolin-1-rich Granule Lumen Regulation Of Microtubule Cytoskeleton Organization Type III Intermediate Filament Cellular Response To Arsenite Ion Lung Goblet Cell Differentiation Mitotic Spindle Astral Microtubule End Protein Localization To Microtubule Centrosome Proteasomal Protein Catabolic Process Cellular Component Assembly Glial Cell Development Mitotic Spindle Pole Proteolysis Involved In Protein Catabolic Process Pseudopodium Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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