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ERBB2 and STUB1
Number of citations of the paper that reports this interaction (PubMedID
12574167
)
0
Data Source:
HPRD
(in vitro, in vivo)
ERBB2
STUB1
Description
erb-b2 receptor tyrosine kinase 2
STIP1 homology and U-box containing protein 1
Image
GO Annotations
Cellular Component
Semaphorin Receptor Complex
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Basal Plasma Membrane
Endosome Membrane
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Cytoplasmic Vesicle
Neuromuscular Junction
Ruffle Membrane
ERBB3:ERBB2 Complex
Presynaptic Membrane
Cell Projection
Myelin Sheath
Receptor Complex
Perinuclear Region Of Cytoplasm
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Z Disc
Ubiquitin Conjugating Enzyme Complex
Nuclear Inclusion Body
Protein Folding Chaperone Complex
Molecular Function
Nucleotide Binding
RNA Polymerase I Core Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Coreceptor Activity
Kinase Activity
Transferase Activity
Growth Factor Binding
Receptor Tyrosine Kinase Binding
Identical Protein Binding
ErbB-3 Class Receptor Binding
Protein Heterodimerization Activity
G Protein-coupled Receptor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Enzyme Binding
Kinase Binding
Hsp70 Protein Binding
Protein-macromolecule Adaptor Activity
TPR Domain Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein Homodimerization Activity
SMAD Binding
Tau Protein Binding
Protein-folding Chaperone Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Ubiquitin Protein Ligase Activity
R-SMAD Binding
Biological Process
Protein Phosphorylation
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Nervous System Development
Peripheral Nervous System Development
Heart Development
Neuromuscular Junction Development
Motor Neuron Axon Guidance
Cell Population Proliferation
Positive Regulation Of Gene Expression
Schwann Cell Development
Peptidyl-tyrosine Phosphorylation
Neuron Differentiation
Positive Regulation Of Cell Growth
Regulation Of Microtubule-based Process
Immature T Cell Proliferation In Thymus
Negative Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Rho Protein Signal Transduction
Intracellular Signal Transduction
ERBB2 Signaling Pathway
ERBB2-ERBB3 Signaling Pathway
ERBB2-EGFR Signaling Pathway
ERBB2-ERBB4 Signaling Pathway
Wound Healing
Regulation Of Cell Population Proliferation
Myelination
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Translation
Regulation Of Angiogenesis
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase I
Oligodendrocyte Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Semaphorin-plexin Signaling Pathway
Positive Regulation Of Protein Targeting To Membrane
Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Positive Regulation Of Intracellular Signal Transduction
MAPK Cascade
Protein Polyubiquitination
Response To Ischemia
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
DNA Damage Response
Signal Transduction
Positive Regulation Of Metabolic Process
Negative Regulation Of Cardiac Muscle Hypertrophy
Protein Ubiquitination
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Glucocorticoid Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Cellular Response To Heat
Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
ERAD Pathway
ERBB2 Signaling Pathway
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Protein Stabilization
Protein Autoubiquitination
Chaperone-mediated Autophagy
Protein K63-linked Ubiquitination
Cellular Response To Misfolded Protein
Cellular Response To Hypoxia
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Positive Regulation Of Mitophagy
Positive Regulation Of ERAD Pathway
Negative Regulation Of Vascular Associated Smooth Muscle Contraction
Pathways
Signaling by ERBB2
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D induced cell migration and growth-cone collapse
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Myoepithelial Cells
Developmental Lineage of Mammary Stem Cells
Downregulation of TGF-beta receptor signaling
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
Regulation of necroptotic cell death
Downregulation of ERBB2 signaling
Regulation of RUNX2 expression and activity
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Trastuzumab
Lapatinib
IGN311
Trastuzumab emtansine
Varlitinib
AV-412
Pertuzumab
Afatinib
Tucatinib
Tesevatinib
Fostamatinib
Brigatinib
Margetuximab
Zanubrutinib
Diseases
Breast cancer
Cervical cancer
Cholangiocarcinoma
Pancreatic cancer
Gastric cancer
Ovarian cancer
Choriocarcinoma
Endometrial Cancer
Bladder cancer
GWAS
Adult asthma (
30787307
)
Asthma (
29273806
31619474
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Bipolar disorder (
27329760
34002096
)
Estimated glomerular filtration rate (
31451708
)
Pancreatic ductal adenocarcinoma (
30541042
)
Polycystic ovary syndrome (
26416764
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
26502338
28714469
)
Ulcerative colitis (
20228799
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Interacting Genes
347 interacting genes:
AATK
ABCB5
ABL1
ABL2
ACP1
ACP3
ADGRB1
AIP
AKAP12
AKT1
ALDOA
ALDOC
ALK
ANKS1A
ANKS1B
ANXA6
AP3B2
APBB1
APBB3
ARF1
ARF5
ARNT
ASRGL1
ATP6AP1
ATP6V0C
AURKA
BAAT
BCAR3
BECN1
BLK
BLNK
BMX
BNIP1
BTC
CACYBP
CALM1
CAV1
CBLC
CBR1
CCDC180
CCND2
CCT3
CD82
CDK4
CDK6
CDK8
CDKN2B
CDKN2C
CEND1
CFAP298
CFL1
CHN1
CISH
CKB
CLASP2
CLCN6
CLNK
COL9A2
COL9A3
CRIP2
CRK
CRKL
CSDE1
CTNNB1
CXCL8
CYLC2
CYP17A1
DAB1
DDR1
DLG4
DOK1
DOK4
DOK6
DST
DUSP14
DUSP18
DUSP19
EGF
EGFR
EPHA1
EPHA3
EPHA4
EPHB1
EPHB3
EPHB6
ERBB3
ERBB4
ERBIN
ERG28
ERRFI1
ESR1
FAM241B
FBP1
FBXO7
FER
FES
FGFR1
FGFR2
FGFR3
FGFR4
FGR
FKBP1A
FKBP3
FKBP8
FLNB
FLT3
FLT4
FRAT2
FZR1
GAB1
GABARAPL1
GABARAPL2
GAPDH
GLCE
GLIS2
GLRX3
GMPR2
GPM6B
GRAP2
GRB10
GRB14
GRB2
GRB7
GRK2
GRM1
GSN
HCK
HDAC6
HDLBP
HGF
HLA-A
HRAS
HSD17B3
HSH2D
HSP90AA1
HSP90AB1
HSP90B1
HSPA1A
HSPA5
HSPA9
HSPD1
IARS1
IGF1R
IL13RA2
IL6ST
ILF3
ILKAP
INPPL1
INSR
IRF2BP2
IRS1
IRS4
ITGA5
ITGB4
ITK
ITPKA
ITPR1
JAK1
JAK2
JMJD4
JUP
KCTD6
KDELR2
KLC1
KLK5
LATS2
LCK
LCP2
LGALS8
LPCAT4
LRRC7
LYPD3
MAP2K1
MAP2K3
MAP2K5
MAPK8IP1
MAPK8IP2
MATK
MDH1
MEPCE
MERTK
MET
MSN
MST1R
MTCH1
MUC1
MUC4
MUCL1
MYC
MYO9A
NAT2
NCK1
NCK2
NEFH
NF2
NINL
NRG1
NTRK1
NTRK2
NTRK3
NUDT16L1
ODF2L
PABPC1
PAK1
PARP1
PDCD11
PDGFRA
PDGFRB
PEBP1
PGAM1
PHF23
PICK1
PIK3C2A
PIK3C2B
PIK3R1
PIK3R2
PIK3R3
PIN4
PLCG1
PLCG2
POLD2
POU6F1
PPA1
PPM1A
PPM1F
PRDM14
PRDX5
PSAP
PSMA1
PSMC3
PSMC3IP
PSMD3
PTGES3L-AARSD1
PTK2
PTK2B
PTK6
PTK7
PTPN11
PTPN18
PTPN6
PTPRR
PTPRT
PTPRU
RAB5C
RAF1
RASA1
RASSF1
RBM15B
RET
RHBDD2
RHOBTB2
RIN1
RIN2
ROR2
RPRML
RTN4
S100A11
SAFB2
SELENOK
SERPINA3
SFRP4
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3A
SH2D3C
SH2D5
SH3BGRL3
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA
SLA2
SLC7A4
SMAD1
SMIM20
SMPD4
SMURF2
SNAP91
SOCS1
SOCS3
SOCS5
SOCS6
SORL1
SOS1
SPP1
SRC
SRPK1
STAP1
STAT3
STIP1
STK11
STK24
STMN1
STMN2
STUB1
STYK1
STYX
SUPT6H
SYK
SYNM
TCEAL2
TEC
TGFA
TGFB1
THRSP
TLN1
TMA7
TMEM134
TMEM230
TNS1
TNS2
TNS3
TOB1
TP53
TRIP6
TRMO
TSEN15
TTC9B
TTYH2
TVP23B
TXK
TXN
TYMP
TYRO3
UBB
USP2
UTP18
VAPA
VAV1
VAV2
VAV3
YES1
YWHAZ
ZAP70
ZFAND1
ZMAT2
ZMYND8
ZNF189
ZNF532
149 interacting genes:
ABL1
ACD
ADRM1
AHR
AQP2
AR
ATCAY
ATXN3
BACE1
BAG1
BAG5
BBOX1
BCR
BMPR1B
CASP6
CCL28
CDK4
CDK9
CDKN1A
CFTR
CIP2A
CRIP1
CTBP2
CTNNB1
CYP2E1
CYP3A4
DAPK1
DAXX
DNAAF4
DNAJB1
E2F8
EGFR
EIF5A
ERBB2
ERG
ERN1
ESR1
FADD
FBXO2
FBXO27
FXR1
GHR
GPR37
GUCY1A1
GUCY1A2
HMGB1
HSF1
HSP90AA1
HSPA1A
HSPA1B
HSPA4
HSPA8
HSPA9
HSPB1
HUNK
INSR
JAK1
JOSD1
JOSD2
KHDRBS1
KPNA2
LRRK1
MAP3K11
MAP3K2
MAP3K21
MAPK3
MAPT
MCF2
METTL14
MFHAS1
MITF
MPP1
MST1R
MYOCD
NOS1
NQO1
NR3C1
OLFM3
OTUD3
PA2G4
PFN1
PKM
PLK1
PMAIP1
POLB
POT1
PPP3CA
PRKACA
PRKCZ
PRKN
PRMT1
PSMA3
PSMC2
PSMD1
PSMD2
PSMD4
RAF1
RFFL
RGS17
RHBDF2
RUNX1
RUNX2
RUSC1
S100A2
S100P
SIRT6
SLC7A11-AS1
SMAD1
SMAD2
SMAD3
SMAD4
SMG5
SMURF1
SNCA
SNPH
SRC
TAL1
TERF1
TGFBR1
TINF2
TP53
TP63
TP73
TPD52
TRAF6
TTN
TXN2
UBB
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2L3
UBE2N
UBE2Q1
UBE2V1
UBE2V2
UBE2W
UNC45B
VCP
VDAC1
XIAP
YTHDF2
Entrez ID
2064
10273
HPRD ID
01281
06232
Ensembl ID
ENSG00000141736
ENSG00000103266
Uniprot IDs
B4DTR1
F5H1T4
J3QLU9
P04626
X5DNK3
Q9UNE7
PDB IDs
1MFG
1MFL
1MW4
1N8Z
1QR1
1S78
2A91
2JWA
2KS1
2L4K
2N2A
3BE1
3H3B
3MZW
3N85
3PP0
3RCD
3WLW
3WSQ
4GFU
4HRL
4HRM
4HRN
4NND
5K33
5KWG
5MY6
5O4G
5OB4
5TQS
6ATT
6BGT
6J71
6LBX
6OGE
7JXH
7MN5
7MN6
7MN8
7PCD
7QVK
8FFJ
8HGO
8HGP
8JYQ
8JYR
8PWH
8Q6J
8U4K
8U4L
8U8X
8VB5
8VQD
8VQE
9L1S
4KBQ
6EFK
6NSV
7TB1
8EHZ
8EI0
8F14
8F15
8F16
8F17
8FYU
8GCK
8SUV
9DRY
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Cell Surface Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Signal Transduction
Protein Kinase Activity
Regulation Of Signal Transduction
ERBB Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Peptidyl-tyrosine Phosphorylation
Kinase Activity
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Non-membrane Spanning Protein Tyrosine Kinase Activity
Cytosol
Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Protein Autophosphorylation
Protein Phosphorylation
Phosphorylation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Plasma Membrane
ATP Binding
Ephrin Receptor Signaling Pathway
Positive Regulation Of Cell Motility
Cell Migration
Positive Regulation Of Locomotion
Protein Kinase Binding
Intracellular Signaling Cassette
Positive Regulation Of Cell Migration
Positive Regulation Of MAPK Cascade
Regulation Of Cell Motility
Phosphate-containing Compound Metabolic Process
Regulation Of Locomotion
Regulation Of Cell Population Proliferation
Regulation Of Cell Adhesion
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cell Motility
Regulation Of Cell Migration
Focal Adhesion
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cellular Component Organization
Nucleotide Binding
Ubiquitin Protein Ligase Binding
Positive Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Macromolecule Metabolic Process
Ubiquitin Conjugating Enzyme Activity
Intracellular Signal Transduction
Cytosol
Regulation Of Primary Metabolic Process
Enzyme Binding
Positive Regulation Of Macromolecule Metabolic Process
ATP Binding
Nucleus
Cytoplasm
Regulation Of Programmed Cell Death
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Catabolic Process
Protein Modification Process
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Nucleotide Binding
Regulation Of Intracellular Signal Transduction
Protein-containing Complex
Protein Polyubiquitination
Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
Regulation Of Post-translational Protein Modification
Positive Regulation Of Biosynthetic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Post-translational Protein Modification
Regulation Of Protein Modification Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Response To Stress
Cellular Response To Stress
Proteasomal Protein Catabolic Process
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