ERBB2 and TLN1

Number of citations of the paper that reports this interaction (PMID 16273093)
170

Data Source:
BioGRID (unspecified method)

		ERBB2	TLN1
Gene Name		erb-b2 receptor tyrosine kinase 2	talin 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Receptor Complex Perinuclear Region Of Cytoplasm	Ruffle Extracellular Region Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase I Core Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Protein C-terminus Binding Growth Factor Binding Protein Phosphatase Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity Protein Dimerization Activity	Insulin Receptor Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Actin Filament Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Peripheral Nervous System Development Heart Development Neuromuscular Junction Development Motor Neuron Axon Guidance Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Cell Growth Positive Regulation Of Rho GTPase Activity Regulation Of Microtubule-based Process Negative Regulation Of Immature T Cell Proliferation In Thymus Fc-epsilon Receptor Signaling Pathway Wound Healing Myelination Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Translation Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade	Platelet Degranulation Movement Of Cell Or Subcellular Component Muscle Contraction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cytoskeletal Anchoring At Plasma Membrane Cell-cell Junction Assembly Cell-substrate Junction Assembly Axon Guidance Blood Coagulation Platelet Activation Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Platelet Aggregation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Axon guidance PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse Innate Immune System Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling Signalling by NGF DAP12 interactions GAB1 signalosome Semaphorin interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Axon guidance Semaphorin interactions p130Cas linkage to MAPK signaling for integrins Smooth Muscle Contraction Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) XBP1(S) activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Platelet activation, signaling and aggregation Unfolded Protein Response (UPR)
Drugs		Trastuzumab Lapatinib ado-trastuzumab emtansine Pertuzumab Afatinib
Diseases
GWAS
Protein-Protein Interactions		110 interactors: ABL1 ABL2 ACPP ANKS1A ANKS1B APBB1 APBB3 BCAR3 BLK BLNK BMX BTC CAV1 CBL CD82 CHN1 CISH CLNK CRK CRKL CTNNB1 DAB1 DLG4 DOK1 DOK4 DOK6 EGF EGFR ERBB2IP ERBB3 ERBB4 ERRFI1 ESR1 FER FGR GRAP2 GRB2 GRB7 HDAC6 HLA-A HSP90AA1 HSP90B1 IL6ST IRS1 IRS4 ITGA5 ITGB4 ITK JAK1 JAK2 JUP MAPK8IP1 MAPK8IP2 MATK MUC1 MUC4 NCK2 NF2 NRG1 PAK1 PICK1 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PTK2 PTK2B PTPN11 PTPN18 RASA1 RIN1 RIN2 SERPINA3 SH2B2 SH2B3 SH2D1B SH2D2A SH2D3A SH2D5 SH3BGRL3 SH3BP2 SHC1 SHC2 SHC3 SLA SLA2 SOCS1 SOS1 SRC SRPK1 STAT1 STAT3 STUB1 SUPT6H SYK TEC TGFA TLN1 TNS2 TNS3 TOB1 TXK UBB USP2 VAV1 VAV2 VAV3	23 interactors: ACTA1 CDK5 DAG1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 NRAP PKD1 PTK2 PTK2B PXN SMURF1 TES TUBA1A VCL YWHAQ
Entrez ID		2064	7094
HPRD ID		01281	01726
Ensembl ID		ENSG00000141736	ENSG00000137076
Uniprot IDs		P04626	Q9Y490
PDB IDs		1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 2KS1 2L4K 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 4GFU	1SYQ 4DJ9
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Communication Signaling Cell Surface Receptor Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Stimulus Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Stimulus Regulation Of Immune Response Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Immune System Process Cellular Response To Organic Substance Regulation Of Kinase Activity Regulation Of Phosphorylation Response To Stress Peptidyl-tyrosine Autophosphorylation Regulation Of Catalytic Activity Response To Organic Substance Cellular Response To Organonitrogen Compound Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Process Cellular Response To Peptide Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Locomotion Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Cell Motility Cell Migration Wound Healing Response To Peptide Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus	Cell-matrix Adhesion Cell-substrate Adhesion Integrin-mediated Signaling Pathway Movement Of Cell Or Subcellular Component Cell Adhesion Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Response To External Stimulus Cell Differentiation Axonogenesis Anatomical Structure Development Extracellular Matrix Organization Extracellular Structure Organization Axon Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Regulation Of Cell Migration Chemotaxis Cell Development Cell Projection Organization Neuron Projection Morphogenesis Regulation Of Cell Motility Developmental Process Multicellular Organismal Development Positive Regulation Of Protein Kinase Activity Regulation Of Locomotion Locomotion Neuron Development Regulation Of Cellular Component Movement Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Single Organismal Cell-cell Adhesion Regulation Of Protein Phosphorylation Positive Regulation Of Transferase Activity Neuron Differentiation Cell Projection Morphogenesis Nervous System Development Regulation Of Phosphorus Metabolic Process Cell Part Morphogenesis Positive Regulation Of Phosphorylation Wound Healing Positive Regulation Of Protein Modification Process Generation Of Neurons Blood Coagulation Cellular Localization Hemostasis Heterotypic Cell-cell Adhesion
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	83a adjacent brainstem clu comprehensive correlating dipg dipgs ef2 fresh frozen glioma h3f3a hedgehog hh hist1h3b hypomethylation morbid multidimensional pediatric pontine profiling ptch signatures specimens subgroups supervised talin upregulation
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	83a adjacent brainstem clu comprehensive correlating dipg dipgs ef2 fresh frozen glioma h3f3a hedgehog hh hist1h3b hypomethylation morbid multidimensional pediatric pontine profiling ptch signatures specimens subgroups supervised talin upregulation
Tagcloud (Intersection) ?