ACTN4 and MICALL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACTN4	MICALL2
Description		actinin alpha 4	MICAL like 2
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynaptic Actin Cytoskeleton Ribonucleoprotein Complex	Stress Fiber Cytoplasm Endosome Cytoskeleton Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Actin Filament Bundle Cell Projection Neuron Projection Recycling Endosome Anchoring Junction
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding	Protein Binding Filamin Binding Small GTPase Binding Actinin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Protein Transport Actin Cytoskeleton Organization Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Muscle Cell Development Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Actin Cytoskeleton Organization Actin Filament Polymerization Neuron Projection Development Endocytic Recycling Rab Protein Signal Transduction Substrate Adhesion-dependent Cell Spreading Bicellular Tight Junction Assembly Endosome Membrane Tubulation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Platelet degranulation Nephrin family interactions
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 34074324) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)	Blood urea nitrogen levels ( 29403010) Creatinine levels ( 29403010) Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder ( 28416812) Glomerular filtration rate ( 29403010) Hematocrit ( 29403010) Hemoglobin ( 29403010) Red blood cell count ( 29403010) Resistance to antihypertensive treatment in hypertension ( 31545351) Restless legs syndrome ( 33239738) Serum uric acid levels ( 29403010 30993211) Zinc levels ( 26025379)
Interacting Genes		60 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A CEBPA COIL COL17A1 DDIAS DSCAM DSCR9 ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NHERF2 NOS2 NOS3 PDE4B PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RNF10 RPS27 SACS SERPINE1 SLC2A4 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR	6 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 CDR2 DCDC2
Entrez ID		81	79778
HPRD ID		05222	11364
Ensembl ID		ENSG00000130402	ENSG00000164877
Uniprot IDs		A0A0S2Z3G9 F5GXS2 H7C144 O43707	Q8IY33
PDB IDs		1WLX 1YDI 2R0O 6O31 6OA6
Enriched GO Terms of Interacting Partners?		Z Disc Actomyosin Structure Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Calmodulin Binding Actin Cytoskeleton Organization Actin Cytoskeleton Positive Regulation Of Metabolic Process Developmental Process Cytoplasm Actin Filament-based Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Macromolecule Biosynthetic Process Telethonin Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication Myofibril Assembly Protein Kinase Binding Anatomical Structure Formation Involved In Morphogenesis Cytoskeleton Organization Actin Binding Anatomical Structure Morphogenesis Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Organization Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Cytokine Production Sarcomere Organization Regulation Of Calcium Ion Transport Actinin Binding Circulatory System Process Structural Constituent Of Muscle Regulation Of Angiogenesis Cardiac Myofibril Assembly Alpha-actinin Binding Negative Regulation Of Developmental Process	Pseudopodium Cortical Actin Cytoskeleton Muscle Cell Development Transmembrane Transporter Binding Integrin Binding Z Disc Focal Adhesion Assembly Actin Filament Binding Cell Junction Cell-substrate Junction Organization Cell-substrate Junction Assembly Sarcomere Platelet Alpha Granule Lumen Actin Cytoskeleton Actin Filament Actin Cytoskeleton Organization Actin Binding Actin Filament-based Process Postsynaptic Actin Cytoskeleton Focal Adhesion Cell Projection Calcium Ion Binding Positive Regulation Of Ion Transmembrane Transporter Activity Cell Junction Assembly Positive Regulation Of Transporter Activity Transcription Coactivator Activity Cell Development Structural Constituent Of Muscle Cytoskeleton Organization Brush Border Cytoskeletal Protein Binding Organelle Organization Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Stress Fiber Cell Junction Organization Actin Filament Uncapping Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Cytoskeleton Positive Regulation Of Cation Transmembrane Transport Structural Constituent Of Postsynapse Titin Z Domain Binding Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Monoatomic Ion Transmembrane Transport Nucleoside Binding Positive Regulation Of Sodium:proton Antiporter Activity Platelet Morphogenesis
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