ACTN4 and CAMK2B

Number of citations of the paper that reports this interaction (PMID 11160423)
40

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		ACTN4	CAMK2B
Gene Name		actinin, alpha 4	calcium/calmodulin-dependent protein kinase II beta
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Z Disc Ribonucleoprotein Complex Cortical Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Neuron Projection Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleoplasm Microtubule Organizing Center Cytosol Plasma Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Spindle Midzone
	Molecular Function	Nucleoside Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Poly(A) RNA Binding Protein N-terminus Binding Actin Filament Binding	Actin Binding Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Protein Homodimerization Activity
	Biological Process	Response To Hypoxia Platelet Degranulation Blood Coagulation Protein Transport Platelet Activation Positive Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Tight Junction Assembly Protein Localization To Tight Junction Regulation Of Nucleic Acid-templated Transcription	G1/S Transition Of Mitotic Cell Cycle Inhibitory G-protein Coupled Receptor Phosphorylation Protein Phosphorylation Calcium Ion Transport Signal Transduction Synaptic Transmission Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Regulation Of Synaptic Transmission, Cholinergic Cellular Response To Heat Response To Cadmium Ion Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Neuromuscular Process Controlling Balance Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Activation Of Meiosis Involved In Egg Activation Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Cellular Response To Heat Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Response to elevated platelet cytosolic Ca2+ Nephrin interactions Platelet degranulation Platelet activation, signaling and aggregation	Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Interferon gamma signaling HSF1-dependent transactivation Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Heart rate ( 23583979)	Metabolic syndrome ( 22399527)
Protein-Protein Interactions		43 interactors: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 ESR1 GSN HDAC7 INO80 ITGB1 KPNA2 LRRC7 MAGI1 MAPK7 MEF2A MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTPN11 PTPN6 RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 STAT1 TJP1 TRIM3 TXN UCHL5 USP6NL VDR	37 interactors: ACOT7 ACTN4 AP5B1 ATXN1 CAMK2D CAMK2N2 CCM2L COL4A3 ETS1 FAM171A2 GAPDH GRIN2A GRIN2B ITPKA KRTAP10-11 KRTAP19-5 KRTAP19-7 MAD2L2 MED18 MGAT5B MORF4L1 MRPL11 MVP PHKB PLCB3 POP5 RAP2B RBFOX2 RBPMS RPL11 RXRG SEMA4G SMYD3 SPRYD7 THRB TTC5 YWHAB
Entrez ID		81	816
HPRD ID		05222	12127
Ensembl ID			ENSG00000058404
Uniprot IDs		O43707	A4D2J9 Q13554
PDB IDs		1WLX 1YDI 2R0O	3BHH
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Negative Regulation Of Signaling Response To Stress Developmental Process Cellular Response To Interferon-gamma Response To Interferon-gamma Negative Regulation Of Signal Transduction Regulation Of Cell Death Response To Abiotic Stimulus Defense Response Cellular Response To Lipid Regulation Of Signaling Regulation Of Apoptotic Process Signal Transduction Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Component Assembly Signaling Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Lipid Multicellular Organismal Development Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Cellular Process Response To Hormone Abortive Mitotic Cell Cycle System Development Mitotic Cell Cycle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide	Negative Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Excitatory Postsynaptic Membrane Potential Intracellular Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Postsynaptic Membrane Potential Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stimulus Regulation Of Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Membrane Depolarization Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transferase Activity Startle Response Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Retinoic Acid Receptor Signaling Pathway Neuromuscular Process Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Protein Autophosphorylation Positive Regulation Of Phosphorylation Regulation Of RNA Metabolic Process Learning Positive Regulation Of Metabolic Process Response To Stress Gene Expression Synaptic Transmission Cardiac Muscle Tissue Growth Regulation Of Erythrocyte Differentiation Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Palmitic Acid Biosynthetic Process Peptidyl-cysteine S-trans-nitrosylation Medium-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty-acyl-CoA Catabolic Process System Development Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Sensory Perception Of Mechanical Stimulus Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation
Tagcloud ?		1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate	1alpha apoptosis apoptotic bcl2 calmodulin enos ep300 epo explore expressions hhcy hif homocysteine hyperhomocysteinemia involvement itraq lower methoxyestradiol mtt neurons overexpression percentage presumed protects suppressed technique transfection tried
Tagcloud (Difference) ?		1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate	1alpha apoptosis apoptotic bcl2 calmodulin enos ep300 epo explore expressions hhcy hif homocysteine hyperhomocysteinemia involvement itraq lower methoxyestradiol mtt neurons overexpression percentage presumed protects suppressed technique transfection tried
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