ACTN4 and INO80

Number of citations of the paper that reports this interaction (PubMedID 20197409)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ACTN4	INO80
Description		actinin alpha 4	INO80 complex ATPase subunit
Image
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynaptic Actin Cytoskeleton Ribonucleoprotein Complex	Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Nuclear Body Ino80 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding	Nucleotide Binding DNA Binding Actin Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Histone Binding Alpha-tubulin Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Protein Transport Actin Cytoskeleton Organization Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Muscle Cell Development Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Mitotic Sister Chromatid Segregation Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair Double-strand Break Repair DNA Recombination Chromatin Remodeling DNA-templated Transcription DNA Damage Response Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Cell Growth Regulation Of Chromosome Organization Cellular Response To UV Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Positive Regulation Of DNA Metabolic Process Spindle Assembly Chromosome Organization Cell Division Regulation Of Cell Cycle Regulation Of DNA Strand Elongation UV-damage Excision Repair Cellular Response To Ionizing Radiation Positive Regulation Of Telomere Maintenance In Response To DNA Damage Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Platelet degranulation Nephrin family interactions	UCH proteinases DNA Damage Recognition in GG-NER
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 34074324) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Appendicular lean mass ( 33097823) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 31451708 31152163) Estimated glomerular filtration rate in non-diabetics ( 31451708) Frailty index ( 34431594) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Macular thickness ( 30535121) Malaria ( 31844061) Menopause (age at onset) ( 26414677) Offspring birth weight ( 31043758) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908)
Interacting Genes		60 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A CEBPA COIL COL17A1 DDIAS DSCAM DSCR9 ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NHERF2 NOS2 NOS3 PDE4B PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RNF10 RPS27 SACS SERPINE1 SLC2A4 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR	2 interacting genes: ACTN4 PLEKHF2
Entrez ID		81	54617
HPRD ID		05222	10024
Ensembl ID		ENSG00000130402	ENSG00000128908
Uniprot IDs		A0A0S2Z3G9 F5GXS2 H7C144 O43707	Q9ULG1
PDB IDs		1WLX 1YDI 2R0O 6O31 6OA6	6HTS 7ZI4
Enriched GO Terms of Interacting Partners?		Z Disc Actomyosin Structure Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Calmodulin Binding Actin Cytoskeleton Organization Actin Cytoskeleton Positive Regulation Of Metabolic Process Developmental Process Cytoplasm Actin Filament-based Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Macromolecule Biosynthetic Process Telethonin Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication Myofibril Assembly Protein Kinase Binding Anatomical Structure Formation Involved In Morphogenesis Cytoskeleton Organization Actin Binding Anatomical Structure Morphogenesis Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Organization Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Cytokine Production Sarcomere Organization Regulation Of Calcium Ion Transport Actinin Binding Circulatory System Process Structural Constituent Of Muscle Regulation Of Angiogenesis Cardiac Myofibril Assembly Alpha-actinin Binding Negative Regulation Of Developmental Process	Nucleoside Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Postsynaptic Actin Cytoskeleton Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Sodium Ion Transmembrane Transport Vesicle Transport Along Actin Filament Nuclear Retinoic Acid Receptor Binding Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Pseudopodium Retinoic Acid Receptor Signaling Pathway Vesicle Cytoskeletal Trafficking Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Substrate Adhesion-dependent Cell Spreading Platelet Alpha Granule Lumen Cellular Localization Tumor Necrosis Factor-mediated Signaling Pathway Protein Transport Establishment Of Protein Localization Positive Regulation Of Transporter Activity Nuclear Receptor Binding Positive Regulation Of Sodium Ion Transport Regulation Of Sodium Ion Transport Actin Filament-based Movement Cortical Actin Cytoskeleton Establishment Of Localization In Cell Negative Regulation Of Cell-substrate Adhesion Intracellular Transport Endosome To Lysosome Transport Regulation Of Transmembrane Transporter Activity Muscle Cell Development Chromatin DNA Binding Intracellular Protein Localization Nuclear Receptor-mediated Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transporter Activity Stress Fiber Regulation Of Non-canonical NF-kappaB Signal Transduction Transport Vesicle Endosome Organization Establishment Of Vesicle Localization Phosphatidylinositol Binding Positive Regulation Of Cation Transmembrane Transport Vesicle Localization Positive Regulation Of Monoatomic Ion Transmembrane Transport Lysosomal Transport
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