ACTN4 and ATP6V1B1

Number of citations of the paper that reports this interaction (PubMedID 10915794)
0

Data Source:
HPRD (in vivo)

		ACTN4	ATP6V1B1
Description		actinin alpha 4	ATPase H+ transporting V1 subunit B1
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynaptic Actin Cytoskeleton Ribonucleoprotein Complex	Vacuolar Proton-transporting V-type ATPase, V1 Domain Cytoplasm Cytosol Plasma Membrane Microvillus Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding	Nucleotide Binding Protein Binding ATP Binding Proton Transmembrane Transporter Activity Protein-containing Complex Binding Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Protein Transport Actin Cytoskeleton Organization Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Muscle Cell Development Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Ossification Renal Water Homeostasis Renal Sodium Ion Transport Prostaglandin Metabolic Process Monoatomic Ion Transport Regulation Of PH Vacuolar Acidification Sensory Perception Of Sound Regulation Of Gene Expression Regulation Of Macroautophagy Adult Behavior Renal Sodium Excretion Olfactory Behavior Inner Ear Morphogenesis PH Reduction ATP Metabolic Process Chloride Ion Homeostasis Calcium Ion Homeostasis Potassium Ion Homeostasis Vacuolar Proton-transporting V-type ATPase Complex Assembly Renal Tubular Secretion Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		Platelet degranulation Nephrin family interactions	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs			Tiludronic acid
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis	Distal renal tubular acidosis (RTA type 1)
GWAS		Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 34074324) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)	Acne (severe) ( 24927181) Urate levels ( 31578528)
Interacting Genes		60 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A CEBPA COIL COL17A1 DDIAS DSCAM DSCR9 ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NHERF2 NOS2 NOS3 PDE4B PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RNF10 RPS27 SACS SERPINE1 SLC2A4 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR	5 interacting genes: ACTN4 KDM1A NHERF1 STX1A SUV39H1
Entrez ID		81	525
HPRD ID		05222	01887
Ensembl ID		ENSG00000130402	ENSG00000116039
Uniprot IDs		A0A0S2Z3G9 F5GXS2 H7C144 O43707	P15313
PDB IDs		1WLX 1YDI 2R0O 6O31 6OA6
Enriched GO Terms of Interacting Partners?		Z Disc Actomyosin Structure Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Calmodulin Binding Actin Cytoskeleton Organization Actin Cytoskeleton Positive Regulation Of Metabolic Process Developmental Process Cytoplasm Actin Filament-based Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Macromolecule Biosynthetic Process Telethonin Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication Myofibril Assembly Protein Kinase Binding Anatomical Structure Formation Involved In Morphogenesis Cytoskeleton Organization Actin Binding Anatomical Structure Morphogenesis Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Organization Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Cytokine Production Sarcomere Organization Regulation Of Calcium Ion Transport Actinin Binding Circulatory System Process Structural Constituent Of Muscle Regulation Of Angiogenesis Cardiac Myofibril Assembly Alpha-actinin Binding Negative Regulation Of Developmental Process	Nucleoside Binding Transmembrane Transporter Binding Organelle Localization Muscle Cell Development Positive Regulation Of Sodium:proton Antiporter Activity Protein-containing Complex Regulation Of Sodium Ion Transport Identical Protein Binding Myosin Head/neck Binding Amide Transport Peptide Transport Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex ENoSc Complex Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Cell Size Type 3 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Renal Phosphate Ion Absorption Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Establishment Of Organelle Localization Vesicle Transport Along Actin Filament ATP-dependent Protein Binding Endomembrane System Response To Gravity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Chloride Channel Inhibitor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Histone H3K9 Trimethyltransferase Activity Histone H3K9me2 Methyltransferase Activity RDNA Heterochromatin Formation Regulation Of DNA Repair RDNA Heterochromatin Microvillus Organization Regulation Of Cellular Component Size Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Establishment Of Golgi Localization Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import
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