ACTN4 and COL17A1

Number of citations of the paper that reports this interaction (PubMedID 11739652)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		ACTN4	COL17A1
Description		actinin alpha 4	collagen type XVII alpha 1 chain
Image
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynaptic Actin Cytoskeleton Ribonucleoprotein Complex	Extracellular Region Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Membrane Hemidesmosome Extracellular Matrix Anchoring Junction
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Protein Transport Actin Cytoskeleton Organization Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Muscle Cell Development Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Cell-matrix Adhesion Epidermis Development Hemidesmosome Assembly
Pathways		Platelet degranulation Nephrin family interactions	Collagen degradation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly Collagen chain trimerization
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis	Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 34074324) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)	Cardiac hypertrophy ( 21348951)
Interacting Genes		60 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A CEBPA COIL COL17A1 DDIAS DSCAM DSCR9 ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NHERF2 NOS2 NOS3 PDE4B PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RNF10 RPS27 SACS SERPINE1 SLC2A4 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR	18 interacting genes: ACTN1 ACTN4 CLSTN1 CSTF2T CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PLOD3 PNKP PPIL1 PPL UBQLN2 WHRN
Entrez ID		81	1308
HPRD ID		05222	00223
Ensembl ID		ENSG00000130402	ENSG00000065618
Uniprot IDs		A0A0S2Z3G9 F5GXS2 H7C144 O43707	Q9UMD9
PDB IDs		1WLX 1YDI 2R0O 6O31 6OA6	8IZS
Enriched GO Terms of Interacting Partners?		Z Disc Actomyosin Structure Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Calmodulin Binding Actin Cytoskeleton Organization Actin Cytoskeleton Positive Regulation Of Metabolic Process Developmental Process Cytoplasm Actin Filament-based Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Macromolecule Biosynthetic Process Telethonin Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication Myofibril Assembly Protein Kinase Binding Anatomical Structure Formation Involved In Morphogenesis Cytoskeleton Organization Actin Binding Anatomical Structure Morphogenesis Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Organization Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Cytokine Production Sarcomere Organization Regulation Of Calcium Ion Transport Actinin Binding Circulatory System Process Structural Constituent Of Muscle Regulation Of Angiogenesis Cardiac Myofibril Assembly Alpha-actinin Binding Negative Regulation Of Developmental Process	Cell-substrate Junction Organization Cell-substrate Junction Assembly Anchoring Junction Hemidesmosome Assembly Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Hemidesmosome Cell Junction Organization Cell-cell Adhesion Intermediate Filament Structural Molecule Activity Wound Healing Cell Adhesion Response To Wounding Focal Adhesion Cell Junction Assembly Extracellular Exosome Z Disc Neuregulin Binding Integrin Binding Cadherin Binding Nail Development Fascia Adherens Cytoskeleton Organization Skin Morphogenesis Insulin-like Growth Factor I Binding Stress Fiber Basement Membrane Muscle Cell Development Pseudopodium Cell Periphery Integrin-mediated Signaling Pathway Structural Constituent Of Cytoskeleton Myelination In Peripheral Nervous System Actin Cytoskeleton Integrin Complex Plasma Membrane Cytoskeleton Anatomical Structure Morphogenesis Desmosome Actin Binding Cell-cell Junction Organization Cell Morphogenesis Adherens Junction Negative Regulation Of Blood Vessel Branching Integrin Alpha6-beta4 Complex X11-like Protein Binding Actin Filament Binding Cell Junction Cell-cell Junction
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