ACTN4 and LCMT2

Number of citations: 47 (PubMedID 25910212)
Data Source: BioGRID (two hybrid)

		ACTN4	LCMT2
Name		actinin alpha 4	leucine carboxyl methyltransferase 2
Structure			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynaptic Actin Cytoskeleton Ribonucleoprotein Complex	Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding	Protein Binding Methyltransferase Activity TRNA Methyltransferase Activity Transferase Activity
	Biological Process	Protein Transport Actin Cytoskeleton Organization Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Muscle Cell Development Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	TRNA Modification TRNA Processing TRNA Methylation Wybutosine Biosynthetic Process Methylation
Pathways		Platelet degranulation Nephrin family interactions	Synthesis of wybutosine at G37 of tRNA(Phe) Synthesis of wybutosine at G37 of tRNA(Phe)
Drugs		None	Leucine
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis	None
GWAS		Brain morphology (MOSTest) ( 32665545 ) Fasting glucose ( 34074324 ) Heart rate ( 23583979 ) Immature fraction of reticulocytes ( 32888494 ) Logical memory (immediate recall) in mild cognitive impairment ( 29274321 ) Mean platelet volume ( 32888494 ) Retinal venular tortuosity ( 31597446 ) Waist circumference ( 28552196 )	Hemoglobin levels ( 32327693 )
Novel Interactors		None recorded	1 novel interactors: COL6A1
Interacting Genes		60 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A CEBPA COIL COL17A1 DDIAS DSCAM DSCR9 ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NHERF2 NOS2 NOS3 PDE4B PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RNF10 RPS27 SACS SERPINE1 SLC2A4 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR	1 interacting genes: ACTN4
Entrez ID		81	9836
HPRD ID		05222	17267
Ensembl ID		ENSG00000130402	ENSG00000168806
Uniprot IDs		A0A0S2Z3G9 F5GXS2 H7C144 O43707	O60294
PDB IDs		1WLX 1YDI 2R0O 6O31 6OA6	Not available
GO Terms Enriched among Interactors		Z Disc Actomyosin Structure Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Calmodulin Binding Actin Cytoskeleton Organization Actin Cytoskeleton Positive Regulation Of Metabolic Process Developmental Process Cytoplasm Actin Filament-based Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Macromolecule Biosynthetic Process Telethonin Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication Myofibril Assembly Protein Kinase Binding Anatomical Structure Formation Involved In Morphogenesis Cytoskeleton Organization Actin Binding Anatomical Structure Morphogenesis Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Organization Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Cytokine Production Sarcomere Organization Regulation Of Calcium Ion Transport Actinin Binding Circulatory System Process Structural Constituent Of Muscle Regulation Of Angiogenesis Cardiac Myofibril Assembly Alpha-actinin Binding Negative Regulation Of Developmental Process	Muscle Cell Development Nucleoside Binding Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Sodium:proton Antiporter Activity Vesicle Transport Along Actin Filament Response To Bleomycin Collagen Type VI Trimer Apoptotic Nuclear Changes Regulation Of Collagen Fibril Organization Skeletal Muscle Tissue Growth Limb Joint Morphogenesis Mitochondrial Depolarization Multicellular Organismal Locomotion Skeletal Muscle Fiber Differentiation Response To Polyamine Macromolecule Reduction Of Food Intake In Response To Dietary Excess Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Caveola Assembly Fat Cell Proliferation Postsynaptic Actin Cytoskeleton Plasma Membrane Raft Assembly Platelet-derived Growth Factor Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Protein-containing Complex Positive Regulation Of Sodium Ion Transmembrane Transport Nuclear Retinoic Acid Receptor Binding Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Pseudopodium Response To Pain Membrane Raft Assembly Plasma Membrane Raft Organization 2-oxoglutarate Metabolic Process Myelination In Peripheral Nervous System Retinoic Acid Receptor Signaling Pathway Cell Development Transmission Of Nerve Impulse Intracellular Vesicle Skeletal Muscle Organ Development Skeletal Muscle Tissue Regeneration Uterus Development Muscle Cell Apoptotic Process Mitochondrial Transmembrane Transport Myotube Differentiation Skeletal Muscle Fiber Development Lung Epithelial Cell Differentiation Membrane Raft Organization Peripheral Nervous System Development Respiratory System Process Lung Cell Differentiation Lung Morphogenesis