NCOR1 and RARG

Number of citations of the paper that reports this interaction (PubMedID 10336495)
0

Data Source:
BioGRID (two hybrid, pull down)

		NCOR1	RARG
Description		nuclear receptor corepressor 1	retinoic acid receptor gamma
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GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Cytosol Membrane Transcription Repressor Complex Mitotic Spindle	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Membrane RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Receptor Binding Histone Deacetylase Binding Nuclear Thyroid Hormone Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Ketone Metabolic Process Locomotor Rhythm Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of JNK Cascade Rhythmic Process Spindle Assembly Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Chondrocyte Development Glandular Epithelial Cell Development Growth Plate Cartilage Development Growth Plate Cartilage Chondrocyte Growth Regulation Of DNA-templated Transcription Apoptotic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Size Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Programmed Cell Death Cell Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cell Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Reproductive Structure Development Gland Development Canonical Wnt Signaling Pathway Limb Development Face Development Bone Development Bone Morphogenesis Epithelium Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cartilage Development Harderian Gland Development Cellular Response To Retinoic Acid Stem Cell Proliferation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Stem Cell Proliferation
Pathways		Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 Heme signaling Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin SR11254 BMS-181156 CD564 Dodecyl-Alpha-D-Maltoside BMS184394 Palovarotene LGD-1550 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid Trifarotene
Diseases
GWAS		Adult body size ( 32376654) C-reactive protein levels ( 30388399) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494)	Anthracycline-induced cardiotoxicity in childhood cancer ( 26237429) Cardiorespiratory fitness (800m run time) ( 32572135) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
Interacting Genes		98 interacting genes: ACTN2 AR ATXN1 ATXN1L ATXN3 BCL6 C1D CBFA2T2 CHD1 CHUK CLK1 CNOT2 COPS2 CSNK2A1 CXADR DACH1 DDX20 DHX30 DZIP3 ENO1 ESR1 ESR2 ETS1 ETS2 GABARAP GABARAPL1 GABARAPL2 GPS2 GTF2B H3C1 H4C1 HDAC3 HDAC5 HDAC9 HESX1 HEY2 HTT KLF5 MAP1LC3A MAP1LC3B MAP1LC3C MECP2 MYB MYBL2 MYOD1 NCOA1 NCOA3 NCOR2 NELFE NR1D1 NR1D2 NR1H2 NR1H3 NR2E3 NR3C1 NR6A1 OVOL2 PDCD2 PHB1 PIAS1 PML POU1F1 PPARA PPARD PPARG PTMA PTOV1 RARA RARG RBPJ RUNX1 RUNX1T1 RXRA SAFB SAP30 SKI SKIL SNW1 SP1 SPEN SQSTM1 SUMO2 TAB2 TAF6 TAF9 TBL1X TBL1XR1 THRA THRB TRIM14 TULP3 TXNRD2 VDR ZBTB16 ZBTB33 ZBTB5 ZBTB7A ZMYND11	33 interacting genes: ACY3 ARID1A BBS4 HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 MYF5 NCOA1 NCOA3 NCOR1 NCOR2 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 PRKAR1B PSMC5 RHPN2 RXRA RXRB RXRG S100A3 SMAD3 SMARCD3 SPHK1 TNIP1 ZNF576
Entrez ID		9611	5916
HPRD ID		02911	01573
Ensembl ID		ENSG00000141027	ENSG00000172819
Uniprot IDs		A0A994J5B8 H0Y459 O75376 Q6PGR4	A8K3H3 B7Z4B4 F1D8P1 P13631
PDB IDs		2EQR 3H52 3KMZ 3N00 4MDD 4WVD 6ONI 6WMQ 6WMS 6XXS 6XYX 6XZZ 6Y17 6ZBU 8AS9 8D8I 8DKN 8DKV 8FHE 8FHG 8FKC 8FKD 8FKE 8FKF 8FKG	1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD 5M24 6FX0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Metabolic Process Nucleus Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process DNA-templated Transcription Chromatin Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Retinoic Acid Receptor Signaling Pathway Transcription Repressor Complex Cell Differentiation Transcription Corepressor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Developmental Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific	Nuclear Receptor Binding Chromatin Nuclear Retinoid X Receptor Binding Nuclear Retinoic Acid Receptor Binding Nuclear Receptor Activity Nuclear Receptor-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Transcription Regulator Complex Retinoic Acid-responsive Element Binding Regulation Of Gene Expression Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleosome Disassembly Protein-DNA Complex Disassembly Nuclear Steroid Receptor Activity Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MiRNA Transcription Positive Regulation Of Biosynthetic Process Nuclear Thyroid Hormone Receptor Binding DNA Binding Sequence-specific DNA Binding Positive Regulation Of Developmental Process Regulation Of Response To Nutrient Levels Regulation Of Metabolic Process Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Transcription Coregulator Binding Positive Regulation Of Bone Mineralization Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Primary Metabolic Process Positive Regulation Of Myoblast Differentiation Somitogenesis MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
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