NCOR1 and NELFE

Number of citations of the paper that reports this interaction (PubMedID 14667819)
0

Data Source:
HPRD (two hybrid)

		NCOR1	NELFE
Description		nuclear receptor corepressor 1	negative elongation factor complex member E
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GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Cytosol Membrane Transcription Repressor Complex Mitotic Spindle	Chromatin Nucleus Nucleoplasm Chromosome Plasma Membrane Nuclear Body NELF Complex
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Receptor Binding Histone Deacetylase Binding Nuclear Thyroid Hormone Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleic Acid Binding Chromatin Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Ketone Metabolic Process Locomotor Rhythm Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of JNK Cascade Rhythmic Process Spindle Assembly Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ERK1 And ERK2 Cascade Transcription Pausing By RNA Polymerase II
Pathways		Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 Heme signaling Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Adult body size ( 32376654) C-reactive protein levels ( 30388399) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494)	A body shape index ( 34021172) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908) vWF levels ( 30586737) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		98 interacting genes: ACTN2 AR ATXN1 ATXN1L ATXN3 BCL6 C1D CBFA2T2 CHD1 CHUK CLK1 CNOT2 COPS2 CSNK2A1 CXADR DACH1 DDX20 DHX30 DZIP3 ENO1 ESR1 ESR2 ETS1 ETS2 GABARAP GABARAPL1 GABARAPL2 GPS2 GTF2B H3C1 H4C1 HDAC3 HDAC5 HDAC9 HESX1 HEY2 HTT KLF5 MAP1LC3A MAP1LC3B MAP1LC3C MECP2 MYB MYBL2 MYOD1 NCOA1 NCOA3 NCOR2 NELFE NR1D1 NR1D2 NR1H2 NR1H3 NR2E3 NR3C1 NR6A1 OVOL2 PDCD2 PHB1 PIAS1 PML POU1F1 PPARA PPARD PPARG PTMA PTOV1 RARA RARG RBPJ RUNX1 RUNX1T1 RXRA SAFB SAP30 SKI SKIL SNW1 SP1 SPEN SQSTM1 SUMO2 TAB2 TAF6 TAF9 TBL1X TBL1XR1 THRA THRB TRIM14 TULP3 TXNRD2 VDR ZBTB16 ZBTB33 ZBTB5 ZBTB7A ZMYND11	11 interacting genes: CACTIN CCDC57 CEBPA MTUS2 NCOR1 NELFB SRPK1 SRPK2 TNKS TRIM27 VAMP3
Entrez ID		9611	7936
HPRD ID		02911	01096
Ensembl ID		ENSG00000141027	ENSG00000204356
Uniprot IDs		A0A994J5B8 H0Y459 O75376 Q6PGR4	A0A1U9X830 P18615
PDB IDs		2EQR 3H52 3KMZ 3N00 4MDD 4WVD 6ONI 6WMQ 6WMS 6XXS 6XYX 6XZZ 6Y17 6ZBU 8AS9 8D8I 8DKN 8DKV 8FHE 8FHG 8FKC 8FKD 8FKE 8FKF 8FKG	1X5P 2BZ2 2JX2 5OOB 6GML 7YCX 8JJ6 8UHA 8UHD 8UHG 8UI0 8W8E 9J0N 9J0O 9J0P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Metabolic Process Nucleus Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process DNA-templated Transcription Chromatin Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Retinoic Acid Receptor Signaling Pathway Transcription Repressor Complex Cell Differentiation Transcription Corepressor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Developmental Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific	Negative Regulation Of Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Viral Process Negative Regulation Of Type I Interferon Production Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Peptidyl-serine Phosphorylation Nucleoplasm RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Innate Immune Response Membraneless Organelle Assembly Positive Regulation Of Viral Process Defense Response Regulation Of Macromolecule Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Response To Vitamin B2 C/EBP Complex Regulation Of Viral Genome Replication Protein Phosphorylation Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric RNA Splicing Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process CHOP-C/EBP Complex Cellular Response To Tumor Necrosis Factor Regulation Of Metabolic Process Retrograde Transport, Endosome To Golgi Phosphorylation Cellular Component Assembly Spindle Assembly Organelle Organization Cellular Response To Cytokine Stimulus Negative Regulation Of Macromolecule Metabolic Process White Fat Cell Proliferation Nuclear Speck Regulation Of Viral Life Cycle MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Organization Microtubule Cytoskeleton Organization NELF Complex Response To Tumor Necrosis Factor Regulation Of Primary Metabolic Process Histone Deacetylase Binding Nuclear Matrix
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