NCOR1 and ETS2

Number of citations of the paper that reports this interaction (PubMedID 15788656)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		NCOR1	ETS2
Description		nuclear receptor corepressor 1	ETS proto-oncogene 2, transcription factor
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GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Cytosol Membrane Transcription Repressor Complex Mitotic Spindle	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Receptor Binding Histone Deacetylase Binding Nuclear Thyroid Hormone Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Nuclear Glucocorticoid Receptor Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Ketone Metabolic Process Locomotor Rhythm Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of JNK Cascade Rhythmic Process Spindle Assembly Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ectodermal Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mesoderm Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Primitive Streak Formation
Pathways		Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 Heme signaling Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Oncogene Induced Senescence
Drugs
Diseases
GWAS		Adult body size ( 32376654) C-reactive protein levels ( 30388399) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494)	Adult body size ( 32376654) Body mass index ( 25673413) Body size at age 10 ( 32376654) C-reactive protein levels ( 30388399) Central corneal thickness ( 32528159) Eye morphology ( 29921221) Fibrinogen levels ( 28107422) Finger osteoarthritis severity (hand Klsum) ( 33055079) Fractures ( 30158200) Intraocular pressure ( 29617998) Non-small cell lung cancer (survival) ( 21079520) Periodontitis (Mean PAL) ( 24024966) Schizophrenia ( 30285260) Serum alkaline phosphatase levels ( 33547301) TPE interval (response to exercise) ( 32386560)
Interacting Genes		98 interacting genes: ACTN2 AR ATXN1 ATXN1L ATXN3 BCL6 C1D CBFA2T2 CHD1 CHUK CLK1 CNOT2 COPS2 CSNK2A1 CXADR DACH1 DDX20 DHX30 DZIP3 ENO1 ESR1 ESR2 ETS1 ETS2 GABARAP GABARAPL1 GABARAPL2 GPS2 GTF2B H3C1 H4C1 HDAC3 HDAC5 HDAC9 HESX1 HEY2 HTT KLF5 MAP1LC3A MAP1LC3B MAP1LC3C MECP2 MYB MYBL2 MYOD1 NCOA1 NCOA3 NCOR2 NELFE NR1D1 NR1D2 NR1H2 NR1H3 NR2E3 NR3C1 NR6A1 OVOL2 PDCD2 PHB1 PIAS1 PML POU1F1 PPARA PPARD PPARG PTMA PTOV1 RARA RARG RBPJ RUNX1 RUNX1T1 RXRA SAFB SAP30 SKI SKIL SNW1 SP1 SPEN SQSTM1 SUMO2 TAB2 TAF6 TAF9 TBL1X TBL1XR1 THRA THRB TRIM14 TULP3 TXNRD2 VDR ZBTB16 ZBTB33 ZBTB5 ZBTB7A ZMYND11	37 interacting genes: CDK10 CLU COP1 CREBBP DAD1 DMXL2 EGLN2 EP300 ERG ETS1 FOCAD FOS GABRD GATA3 GTF3C4 JUN NCOR1 NDRG1 NDUFB5 NR3C1 POU5F1 PPME1 RPL15 SERPINE2 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 TERF2IP TTC3 UBC USP7 ZBTB44 ZFYVE9 ZMYND11
Entrez ID		9611	2114
HPRD ID		02911	01263
Ensembl ID		ENSG00000141027	ENSG00000157557
Uniprot IDs		A0A994J5B8 H0Y459 O75376 Q6PGR4	P15036
PDB IDs		2EQR 3H52 3KMZ 3N00 4MDD 4WVD 6ONI 6WMQ 6WMS 6XXS 6XYX 6XZZ 6Y17 6ZBU 8AS9 8D8I 8DKN 8DKV 8FHE 8FHG 8FKC 8FKD 8FKE 8FKF 8FKG	4BQA 4MHV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Metabolic Process Nucleus Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process DNA-templated Transcription Chromatin Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Retinoic Acid Receptor Signaling Pathway Transcription Repressor Complex Cell Differentiation Transcription Corepressor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Developmental Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific	Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Chromatin Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding DNA Binding Myeloid Cell Differentiation Chromatin Organization Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Histone H3K27 Acetyltransferase Activity Positive Regulation Of Leukocyte Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Pro-T Cell Differentiation Mononuclear Cell Differentiation Host-mediated Activation Of Viral Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Cell Activation Response To Stress Myeloid Leukocyte Activation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lymphocyte Differentiation Regulation Of Cell-cell Adhesion DNA-binding Transcription Factor Activity Transcription Regulator Complex Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Leukocyte Differentiation
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