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NCOR1 and PHB1
Number of citations of the paper that reports this interaction (PubMedID
12466959
)
0
Data Source:
HPRD
(in vivo)
NCOR1
PHB1
Description
nuclear receptor corepressor 1
prohibitin 1
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Chromatin
Nucleus
Nucleoplasm
Cytosol
Membrane
Transcription Repressor Complex
Mitotic Spindle
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Early Endosome
Plasma Membrane
Cell Surface
Membrane
Mitochondrial Prohibitin Complex
Extracellular Exosome
Molecular Function
Transcription Cis-regulatory Region Binding
DNA Binding
Transcription Corepressor Activity
Protein Binding
Nuclear Receptor Binding
Histone Deacetylase Binding
Nuclear Thyroid Hormone Receptor Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Complement Component C3a Binding
Complement Component C3b Binding
Transcription Corepressor Activity
Protein Binding
Enzyme Binding
Proteinase Activated Receptor Binding
Histone Deacetylase Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Regulation Of Ketone Metabolic Process
Locomotor Rhythm
Negative Regulation Of Glycolytic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Fatty Acid Metabolic Process
Negative Regulation Of JNK Cascade
Rhythmic Process
Spindle Assembly
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of MiRNA Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Positive Regulation Of Immunoglobulin Production
Regulation Of DNA-templated Transcription
Mitochondrion Organization
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription By Competitive Promoter Binding
Negative Regulation Of Cell Growth
Positive Regulation Of Interleukin-17 Production
RIG-I Signaling Pathway
Epigenetic Regulation Of Gene Expression
B Cell Activation
Negative Regulation Of Protein Catabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Host-mediated Perturbation Of Viral RNA Genome Replication
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Complement Activation
Symbiont Entry Into Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Progesterone Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interleukin-6
DNA Biosynthetic Process
T-helper 17 Type Immune Response
Antiviral Innate Immune Response
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways
Nuclear signaling by ERBB4
Nuclear signaling by ERBB4
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Cytoprotection by HMOX1
Heme signaling
Heme signaling
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Expression of BMAL (ARNTL), CLOCK, and NPAS2
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
RAF activation
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Processing of SMDT1
Signaling downstream of RAS mutants
Drugs
Rocaglamide
Didesmethylrocaglamide
Diseases
GWAS
Adult body size (
32376654
)
C-reactive protein levels (
30388399
)
FEV1 (
30804560
)
Free thyroxine concentration (
30367059
)
Lung function (FEV1) (
26635082
)
Lung function (FVC) (
30804560
)
Lymphocyte count (
32888494
)
Interacting Genes
98 interacting genes:
ACTN2
AR
ATXN1
ATXN1L
ATXN3
BCL6
C1D
CBFA2T2
CHD1
CHUK
CLK1
CNOT2
COPS2
CSNK2A1
CXADR
DACH1
DDX20
DHX30
DZIP3
ENO1
ESR1
ESR2
ETS1
ETS2
GABARAP
GABARAPL1
GABARAPL2
GPS2
GTF2B
H3C1
H4C1
HDAC3
HDAC5
HDAC9
HESX1
HEY2
HTT
KLF5
MAP1LC3A
MAP1LC3B
MAP1LC3C
MECP2
MYB
MYBL2
MYOD1
NCOA1
NCOA3
NCOR2
NELFE
NR1D1
NR1D2
NR1H2
NR1H3
NR2E3
NR3C1
NR6A1
OVOL2
PDCD2
PHB1
PIAS1
PML
POU1F1
PPARA
PPARD
PPARG
PTMA
PTOV1
RARA
RARG
RBPJ
RUNX1
RUNX1T1
RXRA
SAFB
SAP30
SKI
SKIL
SNW1
SP1
SPEN
SQSTM1
SUMO2
TAB2
TAF6
TAF9
TBL1X
TBL1XR1
THRA
THRB
TRIM14
TULP3
TXNRD2
VDR
ZBTB16
ZBTB33
ZBTB5
ZBTB7A
ZMYND11
27 interacting genes:
ANXA2
BCAS3
CASC3
CCL5
CD40LG
COX6C
E2F1
ESR1
HDAC1
LONRF3
MAP1LC3A
MAP3K10
MCM2
NCOR1
PTEN
RAF1
RB1
RBL1
RBL2
SEC22A
SIN3A
SMARCA2
SMARCA4
ST14
SUMO4
TP53
XPO1
Entrez ID
9611
5245
HPRD ID
02911
01454
Ensembl ID
ENSG00000141027
ENSG00000167085
Uniprot IDs
A0A994J5B8
H0Y459
O75376
Q6PGR4
A8K401
P35232
Q53FV0
PDB IDs
2EQR
3H52
3KMZ
3N00
4MDD
4WVD
6ONI
6WMQ
6WMS
6XXS
6XYX
6XZZ
6Y17
6ZBU
8AS9
8D8I
8DKN
8DKV
8FHE
8FHG
8FKC
8FKD
8FKE
8FKF
8FKG
8RRH
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
DNA Binding
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Nuclear Receptor Activity
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nuclear Receptor-mediated Signaling Pathway
Hormone-mediated Signaling Pathway
Regulation Of Metabolic Process
Nucleus
Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Intracellular Receptor Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
DNA-binding Transcription Factor Activity
Positive Regulation Of Metabolic Process
DNA-templated Transcription
Chromatin
Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Retinoic Acid Receptor Signaling Pathway
Transcription Repressor Complex
Cell Differentiation
Transcription Corepressor Activity
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Cellular Developmental Process
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Transcription Regulator Complex
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Lipid Kinase Activity
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Chromatin Organization
Chromatin
Regulation Of Primary Metabolic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Enzyme Binding
Regulation Of Gene Expression
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Transcription Corepressor Activity
Positive Regulation Of Stem Cell Population Maintenance
Negative Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Negative Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Heterochromatin Formation
Rhythmic Process
Transcription Repressor Complex
Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Process
Epigenetic Regulation Of Gene Expression
Circadian Behavior
Promoter-specific Chromatin Binding
Regulation Of Stem Cell Population Maintenance
Negative Regulation Of Gene Expression
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of MiRNA Transcription
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