NCOR1 and PDCD2

Number of citations of the paper that reports this interaction (PubMedID 12149646)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		NCOR1	PDCD2
Description		nuclear receptor corepressor 1	programmed cell death 2
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Cytosol Membrane Transcription Repressor Complex Mitotic Spindle	Nucleus Cytoplasm Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Receptor Binding Histone Deacetylase Binding Nuclear Thyroid Hormone Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	DNA Binding Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Ketone Metabolic Process Locomotor Rhythm Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of JNK Cascade Rhythmic Process Spindle Assembly Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription	Apoptotic Process Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 Heme signaling Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS		Adult body size ( 32376654) C-reactive protein levels ( 30388399) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)
Interacting Genes		98 interacting genes: ACTN2 AR ATXN1 ATXN1L ATXN3 BCL6 C1D CBFA2T2 CHD1 CHUK CLK1 CNOT2 COPS2 CSNK2A1 CXADR DACH1 DDX20 DHX30 DZIP3 ENO1 ESR1 ESR2 ETS1 ETS2 GABARAP GABARAPL1 GABARAPL2 GPS2 GTF2B H3C1 H4C1 HDAC3 HDAC5 HDAC9 HESX1 HEY2 HTT KLF5 MAP1LC3A MAP1LC3B MAP1LC3C MECP2 MYB MYBL2 MYOD1 NCOA1 NCOA3 NCOR2 NELFE NR1D1 NR1D2 NR1H2 NR1H3 NR2E3 NR3C1 NR6A1 OVOL2 PDCD2 PHB1 PIAS1 PML POU1F1 PPARA PPARD PPARG PTMA PTOV1 RARA RARG RBPJ RUNX1 RUNX1T1 RXRA SAFB SAP30 SKI SKIL SNW1 SP1 SPEN SQSTM1 SUMO2 TAB2 TAF6 TAF9 TBL1X TBL1XR1 THRA THRB TRIM14 TULP3 TXNRD2 VDR ZBTB16 ZBTB33 ZBTB5 ZBTB7A ZMYND11	7 interacting genes: ERRFI1 HCFC1 LSM8 NCOR1 NFKBIB PRKN TBC1D21
Entrez ID		9611	5134
HPRD ID		02911	02922
Ensembl ID		ENSG00000141027	ENSG00000071994
Uniprot IDs		A0A994J5B8 H0Y459 O75376 Q6PGR4	A0A087WYJ3 F5H4V9 J3QK82 Q16342
PDB IDs		2EQR 3H52 3KMZ 3N00 4MDD 4WVD 6ONI 6WMQ 6WMS 6XXS 6XYX 6XZZ 6Y17 6ZBU 8AS9 8D8I 8DKN 8DKV 8FHE 8FHG 8FKC 8FKD 8FKE 8FKF 8FKG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Metabolic Process Nucleus Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process DNA-templated Transcription Chromatin Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Retinoic Acid Receptor Signaling Pathway Transcription Repressor Complex Cell Differentiation Transcription Corepressor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Developmental Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific	Negative Regulation Of MAPK Cascade Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of JNK Cascade Regulation Of Phosphorus Metabolic Process Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Regulation Of ATP Metabolic Process Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Response To Glucocorticoid Negative Regulation Of Intralumenal Vesicle Formation Negative Regulation Of Kinase Activity Regulation Of Purine Nucleotide Metabolic Process Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Kinase Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway SH3 Domain Binding Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Histone Deacetylase Binding Response To Curcumin Negative Regulation Of Phosphorylation Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of JNK Cascade Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Response To Corticosteroid Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Regulation Of MAPK Cascade Negative Regulation Of Catalytic Activity Release From Viral Latency Type 2 Mitophagy Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Regulation Of Synaptic Vesicle Transport Sperm Mitochondrial Sheath Assembly Lewy Body Regulation Of Spontaneous Synaptic Transmission Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake
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