NCOR1 and TXNRD2

Number of citations of the paper that reports this interaction (PubMedID 18978041)
39

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (two hybrid, in vitro)

		NCOR1	TXNRD2
Description		nuclear receptor corepressor 1	thioredoxin reductase 2
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Cytosol Membrane Transcription Repressor Complex Mitotic Spindle	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Axon Dendrite Neuronal Cell Body
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Receptor Binding Histone Deacetylase Binding Nuclear Thyroid Hormone Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Thioredoxin-disulfide Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Protein Homodimerization Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Ketone Metabolic Process Locomotor Rhythm Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of JNK Cascade Rhythmic Process Spindle Assembly Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription	Response To Oxygen Radical Response To Oxidative Stress Response To Selenium Ion Cell Redox Homeostasis Response To Hyperoxia Cellular Oxidant Detoxification
Pathways		Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 Heme signaling Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Detoxification of Reactive Oxygen Species
Drugs			Motexafin gadolinium
Diseases
GWAS		Adult body size ( 32376654) C-reactive protein levels ( 30388399) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494)	Glaucoma ( 30054594 31959993) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary angle closure) ( 22922875) Glaucoma (primary open-angle) ( 26752265 29891935 33627673) Intraocular pressure ( 29785010 30054594 31959993) Lean body mass ( 28552196) Staphylococcus aureus infection ( 24847357)
Interacting Genes		98 interacting genes: ACTN2 AR ATXN1 ATXN1L ATXN3 BCL6 C1D CBFA2T2 CHD1 CHUK CLK1 CNOT2 COPS2 CSNK2A1 CXADR DACH1 DDX20 DHX30 DZIP3 ENO1 ESR1 ESR2 ETS1 ETS2 GABARAP GABARAPL1 GABARAPL2 GPS2 GTF2B H3C1 H4C1 HDAC3 HDAC5 HDAC9 HESX1 HEY2 HTT KLF5 MAP1LC3A MAP1LC3B MAP1LC3C MECP2 MYB MYBL2 MYOD1 NCOA1 NCOA3 NCOR2 NELFE NR1D1 NR1D2 NR1H2 NR1H3 NR2E3 NR3C1 NR6A1 OVOL2 PDCD2 PHB1 PIAS1 PML POU1F1 PPARA PPARD PPARG PTMA PTOV1 RARA RARG RBPJ RUNX1 RUNX1T1 RXRA SAFB SAP30 SKI SKIL SNW1 SP1 SPEN SQSTM1 SUMO2 TAB2 TAF6 TAF9 TBL1X TBL1XR1 THRA THRB TRIM14 TULP3 TXNRD2 VDR ZBTB16 ZBTB33 ZBTB5 ZBTB7A ZMYND11	8 interacting genes: BCAS2 CFTR GTF2H1 NCOA2 NCOA6 NCOR1 PSMC3 TADA3
Entrez ID		9611	10587
HPRD ID		02911	18519
Ensembl ID		ENSG00000141027	ENSG00000184470
Uniprot IDs		A0A994J5B8 H0Y459 O75376 Q6PGR4	A0A096LPD9 E7EWK1 Q9NNW7
PDB IDs		2EQR 3H52 3KMZ 3N00 4MDD 4WVD 6ONI 6WMQ 6WMS 6XXS 6XYX 6XZZ 6Y17 6ZBU 8AS9 8D8I 8DKN 8DKV 8FHE 8FHG 8FKC 8FKD 8FKE 8FKF 8FKG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Metabolic Process Nucleus Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process DNA-templated Transcription Chromatin Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Retinoic Acid Receptor Signaling Pathway Transcription Repressor Complex Cell Differentiation Transcription Corepressor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Developmental Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific	Nuclear Receptor Binding Nuclear Thyroid Hormone Receptor Binding Transcription Coactivator Activity Locomotor Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Chromatin Binding Circadian Behavior Rhythmic Behavior Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleotide-excision Repair Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Initiation Nucleoplasm Positive Regulation Of Biosynthetic Process Positive Regulation Of Anion Channel Activity Spindle Assembly Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Monoatomic Anion Transport Cellular Response To Thyroglobulin Triiodothyronine Positive Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Enamel Mineralization Circadian Rhythm Mitotic Spindle Transepithelial Water Transport Hormone-mediated Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Response To Thyroglobulin Triiodothyronine Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Tooth Mineralization Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Proteasome-activating Activity Spindle Organization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?