SNTA1 and TGFA

Number of citations of the paper that reports this interaction (PubMedID 10230395)
0

Data Source:
HPRD (two hybrid, in vitro)

		SNTA1	TGFA
Description		syntrophin alpha 1	transforming growth factor alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Anchoring Junction	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding ATPase Binding	Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Regulation Of Heart Rate Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport	Angiogenesis Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Intracellular Signal Transduction ERBB2-EGFR Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Mammary Gland Alveolus Development Hepatocyte Proliferation
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Gastric cancer
GWAS		HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)	Acne (severe) ( 24927181) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Hair shape ( 29220522) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549) Hip minimal joint space width ( 27701424) Longevity ( 20834067) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Low hand grip strength (60 years and older) (FNIH) ( 33510174) Neutrophil count ( 21507922) Obesity-related traits ( 23251661) Osteoarthritis ( 30664745) Pulse pressure in young-onset hypertension ( 24892410) Response to citalopram or escitalopram in depression ( 27622933) Response to esketamine in treatment resistant depression ( 32724131) Severe progression in rheumatoid arthritis ( 29065906) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		76 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB ENTREP3 F8A1 FABP1 GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TIAM1 TLX3 TRA TRBV12-3 UTRN VANGL2 XRCC6	17 interacting genes: ADAM10 ADAM17 EGFR ELANE ERBB2 ERBB4 GORASP1 GORASP2 LEPROTL1 MAGI2 MAGI3 NKD2 RHBDD1 RHBDF1 SDCBP SGTA SNTA1
Entrez ID		6640	7039
HPRD ID		03009	07522
Ensembl ID		ENSG00000101400	ENSG00000163235
Uniprot IDs		B3KTR0 Q13424	E7EPT6 F8VNR3 P01135
PDB IDs			1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF 5KN5 7SZ5 7SZ7
Enriched GO Terms of Interacting Partners?		Plasma Membrane System Process Regulation Of System Process Membrane G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Blood Circulation Circulatory System Process Vascular Process In Circulatory System Monoatomic Ion Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Blood Vessel Diameter Maintenance Regulation Of Tube Size Basolateral Plasma Membrane Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Transmembrane Transport Muscle Contraction Inorganic Ion Transmembrane Transport Metal Ion Transport Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Cardiac Muscle Cell Action Potential Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Muscle System Process Synapse Inward Rectifier Potassium Channel Activity Synaptic Signaling Vasodilation Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Adrenergic Receptor Activity CGMP-mediated Signaling Calcium-mediated Signaling Action Potential Potassium Ion Transport Regulation Of Blood Pressure Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Voltage-gated Sodium Channel Complex Signal Transduction Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organismal Process	Localization Within Membrane Positive Regulation Of Growth Positive Regulation Of Cell Growth Cellular Localization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endopeptidase Activity Establishment Of Protein Localization To Membrane ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Activity Positive Regulation Of Phosphorylation Membrane Membrane Protein Proteolysis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Population Proliferation ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Growth Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Regulation Of Cell Migration Regulation Of Signal Transduction Golgi Membrane Regulation Of Protein Catabolic Process Metallodipeptidase Activity ERBB2-EGFR Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Growth ERBB4 Signaling Pathway Basal Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Regulation Of Locomotion Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Neuromuscular Junction Positive Regulation Of Protein Phosphorylation ATPase Binding Regulation Of Cell Communication Regulation Of Signaling Basolateral Plasma Membrane Positive Regulation Of T Cell Chemotaxis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of T Cell Chemotaxis
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