SNTA1 and ABCC4

Number of citations of the paper that reports this interaction (PubMedID 18045536)
28

Data Source:
BioGRID (pull down)

		SNTA1	ABCC4
Description		syntrophin alpha 1	ATP binding cassette subfamily C member 4 (PEL blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Anchoring Junction	Nucleolus Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Platelet Dense Granule Membrane External Side Of Apical Plasma Membrane
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding ATPase Binding	Nucleotide Binding Guanine Nucleotide Transmembrane Transporter Activity Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Prostaglandin Transmembrane Transporter Activity Urate Transmembrane Transporter Activity Purine Nucleotide Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ABC-type Bile Acid Transporter Activity Efflux Transmembrane Transporter Activity 15-hydroxyprostaglandin Dehydrogenase (NAD+) Activity ATP Hydrolysis Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Regulation Of Heart Rate Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport	Platelet Degranulation Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Lipid Transport Bile Acid And Bile Salt Transport Prostaglandin Transport Urate Transport Prostaglandin Secretion Glutathione Transmembrane Transport Transmembrane Transport Cilium Assembly CAMP Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Export Across Plasma Membrane Transport Across Blood-brain Barrier Guanine Nucleotide Transmembrane Transport
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Platelet degranulation ABC-family proteins mediated transport Azathioprine ADME Paracetamol ADME
Drugs			ATP
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)	Acute post-radiotherapy pain in breast cancer ( 31196165) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Breast cancer ( 17903305) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Longevity ( 20834067) Parent of origin effect on language impairment (paternal) ( 24571439) Platelet count ( 22139419 27863252 29403010 32888494) Plateletcrit ( 27863252 32888494) Postherpetic neuralgia ( 33685280) Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer ( 23478653) Serum metabolite levels ( 33031748)
Interacting Genes		76 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB ENTREP3 F8A1 FABP1 GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TIAM1 TLX3 TRA TRBV12-3 UTRN VANGL2 XRCC6	6 interacting genes: ERBIN MPP1 NHERF1 NHERF2 PDZK1 SNTA1
Entrez ID		6640	10257
HPRD ID		03009	05583
Ensembl ID		ENSG00000101400	ENSG00000125257
Uniprot IDs		B3KTR0 Q13424	A8K2Q2 O15439
PDB IDs			8BJF 8BWO 8BWP 8BWQ 8BWR 8I4A 8I4B 8I4C 8IZ7 8IZ8 8IZ9 8IZA 8J3W 8J3Z 8XOK 8XOL 8XOM
Enriched GO Terms of Interacting Partners?		Plasma Membrane System Process Regulation Of System Process Membrane G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Blood Circulation Circulatory System Process Vascular Process In Circulatory System Monoatomic Ion Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Blood Vessel Diameter Maintenance Regulation Of Tube Size Basolateral Plasma Membrane Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Transmembrane Transport Muscle Contraction Inorganic Ion Transmembrane Transport Metal Ion Transport Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Cardiac Muscle Cell Action Potential Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Muscle System Process Synapse Inward Rectifier Potassium Channel Activity Synaptic Signaling Vasodilation Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Adrenergic Receptor Activity CGMP-mediated Signaling Calcium-mediated Signaling Action Potential Potassium Ion Transport Regulation Of Blood Pressure Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Voltage-gated Sodium Channel Complex Signal Transduction Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organismal Process	Signaling Receptor Binding Protein-membrane Adaptor Activity Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding PDZ Domain Binding Protein Localization To Plasma Membrane Microvillus Membrane Protein Localization To Cell Periphery Stereocilium Protein Localization To Membrane Brush Border Membrane Phosphatase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Apical Plasma Membrane Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Plasma Membrane Neuromuscular Junction Renal Phosphate Ion Absorption Localization Within Membrane Beta-catenin Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Basal Protein Localization ErbB-2 Class Receptor Binding Intracellular Protein Localization Scavenger Receptor Binding Syntrophin Complex Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Molecular Adaptor Activity Growth Factor Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Negative Regulation Of Monocyte Chemotactic Protein-1 Production Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Hemidesmosome GMP Kinase Activity Intracellular Phosphate Ion Homeostasis
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