SNTA1 and ABCC4

Number of citations of the paper that reports this interaction (PMID 18045536)
52

Data Source:
BioGRID (pull down)

		SNTA1	ABCC4
Gene Name		syntrophin, alpha 1	ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Cytoskeleton Syntrophin Complex Lateral Plasma Membrane Cell Junction Neuromuscular Junction Sarcolemma Protein Complex Postsynaptic Membrane	Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Platelet Dense Granule Membrane
	Molecular Function	Actin Binding Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Ion Channel Binding Nitric-oxide Synthase Binding ATPase Binding	ATP Binding 15-hydroxyprostaglandin Dehydrogenase (NAD+) Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Regulation Of Heart Rate Regulation Of Vasoconstriction By Circulating Norepinephrine Muscle Contraction Neuromuscular Junction Development Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport	Platelet Degranulation Blood Coagulation Biological_process Response To Organonitrogen Compound Response To Organic Cyclic Compound Platelet Activation Response To Drug Positive Regulation Of Smooth Muscle Cell Proliferation Transmembrane Transport Oxidation-reduction Process
Pathways			ABC-family proteins mediated transport Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Breast cancer ( 17903305) Longevity ( 20834067) Platelet counts ( 22139419) Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer ( 23478653)
Protein-Protein Interactions		72 interactors: ABCA1 ABCC4 ACTA2 ADAMTS6 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B BAI1 BAI2 BAI3 C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA F8A1 FABP1 FAM189B GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TLX3 TRA TRBV12-3 UTRN XRCC6	5 interactors: ERBB2IP PDZK1 SLC9A3R1 SLC9A3R2 SNTA1
Entrez ID		6640	10257
HPRD ID		03009	05583
Ensembl ID		ENSG00000101400	ENSG00000125257
Uniprot IDs		B4DX40 Q13424	B7Z3Q7 O15439
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Synaptic Transmission Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Muscle System Process Muscle Contraction Regulation Of Heart Contraction G-protein Coupled Receptor Signaling Pathway Metal Ion Transport Ion Transport Regulation Of Muscle Contraction Blood Circulation Negative Regulation Of Adrenergic Receptor Signaling Pathway Monovalent Inorganic Cation Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Cation Transport Regulation Of Striated Muscle Contraction Cell Surface Receptor Signaling Pathway Cation Transmembrane Transport Transmembrane Transport Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Homeostasis Positive Regulation Of Cell Proliferation Ion Transmembrane Transport Potassium Ion Import Regulation Of Phosphorus Metabolic Process Behavior Response To Stimulus Regulation Of Membrane Potential Positive Regulation Of Transport Regulation Of Cellular Process Regulation Of Sodium Ion Transport CGMP Metabolic Process Positive Regulation Of Ion Transport Response To Drug Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Action Potential Regulation Of Body Fluid Levels Multicellular Organismal Response To Stress Response To Stress Cellular Response To Stimulus	Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Sodium Ion Transport Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Ion Transport Regulation Of Vasoconstriction By Circulating Norepinephrine Renal Phosphate Ion Absorption Monocarboxylic Acid Transport Basal Protein Localization Glutathione Transport Negative Regulation Of Sodium:proton Antiporter Activity Renal Sodium Ion Transport Negative Regulation Of Peptidyl-cysteine S-nitrosylation Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Protein Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Bile Acid Secretion Oligopeptide Transport Carnitine Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Phosphate Ion Homeostasis Negative Regulation Of Intracellular Signal Transduction Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Organic Anion Transport Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Quaternary Ammonium Group Transport Ventricular Cardiac Muscle Cell Action Potential Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization Regulation Of Membrane Repolarization Regulation Of Excretion Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transporter Activity Bile Acid And Bile Salt Transport Positive Regulation Of Protein Targeting To Membrane Monovalent Inorganic Cation Transport
Tagcloud ?		acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound	abcb1 antagonize antioxidants caco cassette chemoresistance cnts concurrently devices dimethylthiourea extrusion forced hold integral mdr mecaptoethanol mrp4 multiwalled mwcnt mwcnts nanotubes overcome pgp promise proto shed transporter transporters
Tagcloud (Difference) ?		acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound	abcb1 antagonize antioxidants caco cassette chemoresistance cnts concurrently devices dimethylthiourea extrusion forced hold integral mdr mecaptoethanol mrp4 multiwalled mwcnt mwcnts nanotubes overcome pgp promise proto shed transporter transporters
Tagcloud (Intersection) ?