SNTA1 and HTR2B

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)

		SNTA1	HTR2B
Description		syntrophin alpha 1	5-hydroxytryptamine receptor 2B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Anchoring Junction	Nucleoplasm Cytoplasm Plasma Membrane Membrane Dendrite Neuron Projection Synapse G Protein-coupled Serotonin Receptor Complex
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding ATPase Binding	Gq/11-coupled Serotonin Receptor Activity G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity GTPase Activator Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity
	Biological Process	Regulation Of Heart Rate Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Heart Morphogenesis Cardiac Muscle Hypertrophy Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Heart Development Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Intestine Smooth Muscle Contraction Calcium-mediated Signaling CGMP-mediated Signaling Vasoconstriction Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Embryonic Morphogenesis Regulation Of Behavior Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Serotonin receptors G alpha (q) signalling events
Drugs			Methysergide Cabergoline Zolmitriptan Dihydroergotamine Methylergometrine Cyproheptadine Chlorpromazine Triflupromazine Amoxapine Fenfluramine Lisuride Ergotamine Apomorphine Paroxetine Paroxetine Minaprine Cyclobenzaprine Ergoloid mesylate Tegaserod Doxepin Pergolide Bromocriptine Ketamine Aripiprazole Chlorprothixene Clomipramine Yohimbine Midomafetamine Lysergic acid diethylamide OPC-28326 Epicept NP-1 PRX-08066 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Esmirtazapine Nandrolone decanoate Viloxazine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)	Proportion of activated microglia (midfrontal cortex) ( 30679421) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		76 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB ENTREP3 F8A1 FABP1 GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TIAM1 TLX3 TRA TRBV12-3 UTRN VANGL2 XRCC6	27 interacting genes: ABCA3 ATP1B1 BNIP3 BNIP3L CBR1 CHPT1 G6PC3 GNA11 GNAQ HAT1 HDGFL2 INSIG1 KIF19 LNX1 MATR3 METRN NAT14 NIPA2 OAZ1 PLLP PPP1R3F RAE1 SLC31A2 SLC37A1 SLC44A2 SNTA1 TRAM1L1
Entrez ID		6640	3357
HPRD ID		03009	03077
Ensembl ID		ENSG00000101400	ENSG00000135914
Uniprot IDs		B3KTR0 Q13424	P41595
PDB IDs			4IB4 4NC3 5TUD 5TVN 6DRX 6DRY 6DRZ 6DS0 7SRQ 7SRR 7SRS
Enriched GO Terms of Interacting Partners?		Plasma Membrane System Process Regulation Of System Process Membrane G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Blood Circulation Circulatory System Process Vascular Process In Circulatory System Monoatomic Ion Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Blood Vessel Diameter Maintenance Regulation Of Tube Size Basolateral Plasma Membrane Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Transmembrane Transport Muscle Contraction Inorganic Ion Transmembrane Transport Metal Ion Transport Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Cardiac Muscle Cell Action Potential Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Muscle System Process Synapse Inward Rectifier Potassium Channel Activity Synaptic Signaling Vasodilation Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Adrenergic Receptor Activity CGMP-mediated Signaling Calcium-mediated Signaling Action Potential Potassium Ion Transport Regulation Of Blood Pressure Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Voltage-gated Sodium Channel Complex Signal Transduction Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organismal Process	Glucose-6-phosphate Transport Phosphatidylcholine Metabolic Process Mitochondrial Protein Catabolic Process Negative Regulation Of Membrane Potential Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Outer Membrane Permeabilization Phospholipase C-activating Serotonin Receptor Signaling Pathway Phototransduction, Visible Light Lysosomal Membrane Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Guanyl Nucleotide Binding Regulation Of Membrane Potential G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Phosphatidylcholine Biosynthetic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Detection Of Visible Light Positive Regulation Of Mitochondrial Membrane Permeability Cellular Response To PH Entrainment Of Circadian Clock Enzyme Regulator Activity Positive Regulation Of Protein Homooligomerization Organophosphate Ester Transport Transmembrane Transport Glycerolipid Metabolic Process Lamellar Body Membrane Membrane Positive Regulation Of Membrane Permeability Mitochondrion Autophagosome Adaptor Activity Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Regulation Of Copper Ion Transmembrane Transport Heterotrimeric G-protein Complex Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Plus-end Specific Microtubule Depolymerization Axonemal Microtubule Depolymerization Regulation Of Sodium Ion Transmembrane Transport Response To PH Phototransduction Acetylcholine Receptor Signaling Pathway
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