TGFA and RHBDF1

Number of citations of the paper that reports this interaction (PMID 15965977)
11

Data Source:
HPRD (in vivo, in vitro)

		TGFA	RHBDF1
Gene Name		transforming growth factor, alpha	rhomboid 5 homolog 1 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Golgi Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Glycoprotein Binding Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Serine-type Endopeptidase Activity Growth Factor Binding
	Biological Process	Activation Of MAPK Activity Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Wound Healing Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation Mammary Gland Alveolus Development	Proteolysis Cell Proliferation Protein Transport Cell Migration Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Secretion Negative Regulation Of Protein Secretion Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Longevity ( 20834067) Neutrophil count ( 21507922) Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: ADAM10 ADAM17 EGFR ELANE ERBB2 ERBB4 GORASP1 GORASP2 MAGI2 MAGI3 NKD2 RHBDF1 SDCBP SGTA SNTA1	1 interactors: TGFA
Entrez ID		7039	64285
HPRD ID		07522	07027
Ensembl ID		ENSG00000163235	ENSG00000007384
Uniprot IDs		E7EPT6 F8VNR3 P01135	Q96CC6
PDB IDs		1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Locomotion Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component PMA-inducible Membrane Protein Ectodomain Proteolysis Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Movement Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Proliferation Cell Migration Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Collagen Catabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Growth Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of T Cell Chemotaxis Regulation Of Cell Proliferation Collagen Metabolic Process Regulation Of ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Multicellular Organismal Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Generation Of Neurons Regulation Of Cell Migration Multicellular Organismal Metabolic Process	Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Receptor Activity Mammary Gland Alveolus Development Mammary Gland Lobule Development Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Regulation Of Receptor Activity Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Division Activation Of MAPK Activity Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Mammary Gland Development Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Cycle Process Regulation Of Cell Division Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Regulation Of Epithelial Cell Proliferation Regulation Of MAP Kinase Activity Angiogenesis
Tagcloud ?		alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfb3 thra1 transforming transmission trios utilizing
Tagcloud (Difference) ?		alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfb3 thra1 transforming transmission trios utilizing
Tagcloud (Intersection) ?