TGFA and ADAM10

Number of citations of the paper that reports this interaction (PMID 12590602)
12

Data Source:
HPRD (in vitro)

		TGFA	ADAM10
Gene Name		transforming growth factor, alpha	ADAM metallopeptidase domain 10
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Golgi Apparatus Golgi-associated Vesicle Plasma Membrane Focal Adhesion Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Perinuclear Endoplasmic Reticulum Tetraspanin-enriched Microdomain
	Molecular Function	Glycoprotein Binding Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Endopeptidase Activity Metalloendopeptidase Activity Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity
	Biological Process	Activation Of MAPK Activity Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Wound Healing Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation Mammary Gland Alveolus Development	In Utero Embryonic Development Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Integrin-mediated Signaling Pathway Cell-cell Signaling Axon Guidance Positive Regulation Of Cell Proliferation Positive Regulation Of T Cell Chemotaxis Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Tumor Necrosis Factor Monocyte Activation Ephrin Receptor Signaling Pathway PMA-inducible Membrane Protein Ectodomain Proteolysis Constitutive Protein Ectodomain Proteolysis
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Degradation of the extracellular matrix Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Collagen degradation Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by EGFR Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS		Longevity ( 20834067) Neutrophil count ( 21507922) Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: ADAM10 ADAM17 EGFR ELANE ERBB2 ERBB4 GORASP1 GORASP2 MAGI2 MAGI3 NKD2 RHBDF1 SDCBP SGTA SNTA1	7 interactors: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TGFA
Entrez ID		7039	102
HPRD ID		07522	03723
Ensembl ID		ENSG00000163235	ENSG00000137845
Uniprot IDs		E7EPT6 F8VNR3 P01135	B4DU28 O14672
PDB IDs		1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF	1M1I
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Locomotion Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component PMA-inducible Membrane Protein Ectodomain Proteolysis Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Movement Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Proliferation Cell Migration Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Collagen Catabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Growth Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of T Cell Chemotaxis Regulation Of Cell Proliferation Collagen Metabolic Process Regulation Of ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Multicellular Organismal Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Generation Of Neurons Regulation Of Cell Migration Multicellular Organismal Metabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Anatomical Structure Morphogenesis Generation Of Neurons Cell Morphogenesis Involved In Differentiation Neurogenesis Cell Surface Receptor Signaling Pathway Cell Development Substrate Adhesion-dependent Cell Spreading Regulation Of Epithelial To Mesenchymal Transition Cell Morphogenesis Axon Guidance Nervous System Development System Development Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Axonogenesis Regulation Of Signal Transduction Multicellular Organismal Development Regulation Of Neuron Differentiation Axon Development Anatomical Structure Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Tissue Remodeling Chemotaxis Organ Development Regulation Of Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Auditory Receptor Cell Differentiation Hemopoiesis Regulation Of Signaling Neuron Projection Morphogenesis Signal Transduction Activation Of MAPK Activity Immune System Development Regulation Of Neurogenesis Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Developmental Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Differentiation Response To External Stimulus Signaling Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell Communication
Tagcloud ?		alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfb3 thra1 transforming transmission trios utilizing	actually ameliorating amyloidogenic appswe bace1 behavioral concept copyright deficits dramatic highlights hyperphosphorylation interpretation jnk modifying neuropathology plaque potently powerfully preclinical protected ps1 ps1de9 reserved rights secretase slow sp600125 vehicle
Tagcloud (Difference) ?		alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfb3 thra1 transforming transmission trios utilizing	actually ameliorating amyloidogenic appswe bace1 behavioral concept copyright deficits dramatic highlights hyperphosphorylation interpretation jnk modifying neuropathology plaque potently powerfully preclinical protected ps1 ps1de9 reserved rights secretase slow sp600125 vehicle
Tagcloud (Intersection) ?