TGFA and MAGI2

Number of citations: 0 (PubMedID 15652357)
Data Source: HPRD (in vitro, two hybrid)

		TGFA	MAGI2
Name		transforming growth factor alpha	membrane associated guanylate kinase, WW and PDZ domain containing 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Perinuclear Region Of Cytoplasm	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Endosome Late Endosome Centrosome Centriole Cytoskeleton Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cilium Postsynaptic Density Membrane Dendrite Protein-containing Complex Slit Diaphragm Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm Ciliary Base
	Molecular Function	Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity	Protein Binding Phosphatase Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding
	Biological Process	Angiogenesis Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Intracellular Signal Transduction ERBB2-EGFR Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Mammary Gland Alveolus Development Hepatocyte Proliferation	Positive Regulation Of Receptor Internalization Endocytosis Signal Transduction Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Protein Signal Transduction Podocyte Development Clathrin-dependent Endocytosis Cellular Response To Nerve Growth Factor Stimulus
Pathways		PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells	Nephrin family interactions
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Gastric cancer	None
GWAS		Acne (severe) ( 24927181 ) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903 ) Hair shape ( 29220522 ) Hand grip strength ( 29691431 29313844 ) Heel bone mineral density ( 30598549 ) Hip minimal joint space width ( 27701424 ) Longevity ( 20834067 ) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174 ) Low hand grip strength (60 years and older) (FNIH) ( 33510174 ) Neutrophil count ( 21507922 ) Obesity-related traits ( 23251661 ) Osteoarthritis ( 30664745 ) Pulse pressure in young-onset hypertension ( 24892410 ) Response to citalopram or escitalopram in depression ( 27622933 ) Response to esketamine in treatment resistant depression ( 32724131 ) Severe progression in rheumatoid arthritis ( 29065906 ) Superior frontal gyrus grey matter volume ( 25335168 )	Acute lymphoblastic leukemia (childhood) ( 23007406 ) Adult body size ( 32376654 ) Adverse response to drug ( 30420678 ) Airway wall thickness ( 25517131 ) Bitter beverage consumption ( 31046077 ) Body mass index ( 25673413 28892062 ) Body size at age 10 ( 32376654 ) Bronchopulmonary dysplasia ( 23897914 ) Chronotype ( 30696823 ) Computer vision syndrome ( 33941792 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444 ) General risk tolerance (MTAG) ( 30643258 ) Hippocampal atrophy ( 19668339 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) LDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535 ) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Lead levels in blood ( 25820613 ) Low density lipoprotein cholesterol levels ( 33339817 ) Mammographic density (dense area) ( 25342443 ) Memory dysfunction in frontotemporal lobe dementia ( 29724592 ) Metabolite levels ( 23823483 ) Nicotine dependence ( 33144568 ) Night sleep phenotypes ( 27126917 ) Obesity-related traits ( 23251661 ) Pursuit maintenance gain ( 29064472 ) Refractive error ( 32231278 ) Response to anti-depressant treatment in major depressive disorder ( 22041458 ) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125 ) Schizophrenia ( 30285260 28991256 ) Serum folate levels ( 29953918 ) Total cholesterol levels ( 33339817 ) Visceral fat ( 30942860 )
Interacting Genes		17 interacting genes: ADAM10 ADAM17 EGFR ELANE ERBB2 ERBB4 GORASP1 GORASP2 LEPROTL1 MAGI2 MAGI3 NKD2 RHBDD1 RHBDF1 SDCBP SGTA SNTA1	30 interacting genes: ACVR2A ADGRB1 ADRB1 ARRDC3 ATN1 CRHR1 CTNNB1 CTNND2 DLGAP1 DLGAP2 DLGAP3 DLL1 DSCAM DSCAML1 DYRK3 GRID2 LCOR MORN4 PDZD11 PLEKHF2 PLXNB3 PRRG4 PTEN RAPGEF2 RIPK4 RPS6KA1 SMAD3 SNRPB TGFA VANGL2
Entrez ID		7039	9863
HPRD ID		07522	16212
Ensembl ID		ENSG00000163235	ENSG00000187391
Uniprot IDs		E7EPT6 F8VNR3 P01135	B7Z4H4 Q86UL8
PDB IDs		1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF 5KN5 7SZ5 7SZ7	1UEP 1UEQ 1UEW 1UJV 1WFV
GO Terms Enriched among Interactors		Localization Within Membrane Positive Regulation Of Growth Positive Regulation Of Cell Growth Cellular Localization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endopeptidase Activity Establishment Of Protein Localization To Membrane ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Activity Positive Regulation Of Phosphorylation Membrane Membrane Protein Proteolysis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Population Proliferation ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Growth Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Regulation Of Cell Migration Regulation Of Signal Transduction Golgi Membrane Regulation Of Protein Catabolic Process Metallodipeptidase Activity ERBB2-EGFR Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Growth ERBB4 Signaling Pathway Basal Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Regulation Of Locomotion Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Neuromuscular Junction Positive Regulation Of Protein Phosphorylation ATPase Binding Regulation Of Cell Communication Regulation Of Signaling Basolateral Plasma Membrane Positive Regulation Of T Cell Chemotaxis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of T Cell Chemotaxis	PDZ Domain Binding Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Junction Assembly Synapse Synapse Organization Regulation Of Nervous System Development Chemical Synaptic Transmission Cell Junction Organization Signaling Postsynaptic Specialization Trans-synaptic Signaling Synaptic Signaling Postsynaptic Density Anchoring Junction System Development Regionalization Cell-cell Signaling Cell Surface Receptor Signaling Pathway Cell Communication Anatomical Structure Morphogenesis Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Cell-cell Junction Synapse Assembly Developmental Process Cell-cell Adhesion Mediator Activity Regulation Of Neurogenesis Glutamatergic Synapse Epithelial Tube Morphogenesis Nervous System Development Regulation Of Striated Muscle Tissue Development Cell Fate Determination Positive Regulation Of Developmental Process Pattern Specification Process Heat Generation Hepatocyte Proliferation Regulation Of Growth Regulation Of Muscle Organ Development Osteoblast Differentiation Gastrulation Embryonic Morphogenesis Animal Organ Development Positive Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Neuron Projection Morphogenesis Cell Junction Assembly Transcription Corepressor Binding Regulation Of Multicellular Organismal Development