SNTA1 and SCN1A

Number of citations of the paper that reports this interaction (PubMedID 9412493)
64

Data Source:
BioGRID (unspecified method)

		SNTA1	SCN1A
Description		syntrophin alpha 1	sodium voltage-gated channel alpha subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Anchoring Junction	Voltage-gated Sodium Channel Complex Nucleoplasm Plasma Membrane Intercalated Disc Membrane Nuclear Body Z Disc T-tubule Axon Node Of Ranvier Monoatomic Ion Channel Complex Sodium Channel Complex Neuronal Cell Body Axon Initial Segment
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding ATPase Binding	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
	Biological Process	Regulation Of Heart Rate Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport	Action Potential Monoatomic Ion Transport Sodium Ion Transport Adult Walking Behavior Determination Of Adult Lifespan Neuronal Action Potential Propagation Neuronal Action Potential Nerve Development Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Neuromuscular Process Controlling Posture Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Establishment Of Localization In Cell Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential Regulation Of Presynaptic Membrane Potential
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Zonisamide Promethazine Phenacemide Chloroprocaine Phenazopyridine Nitrazepam Permethrin Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	Familial or sporadic hemiplegic migraine Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI)
GWAS		HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)	Epilepsy ( 25087078 30531953) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 22949513 30531953) Mesial temporal lobe epilepsy with hippocampal sclerosis ( 24014518) Whole brain grey matter density ( 31530798)
Interacting Genes		76 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB ENTREP3 F8A1 FABP1 GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TIAM1 TLX3 TRA TRBV12-3 UTRN VANGL2 XRCC6	5 interacting genes: CALM1 NEDD4 PSEN1 SNTA1 YAP1
Entrez ID		6640	6323
HPRD ID		03009	01669
Ensembl ID		ENSG00000101400	ENSG00000144285
Uniprot IDs		B3KTR0 Q13424	A0A286YF26 P35498
PDB IDs			7DTD
Enriched GO Terms of Interacting Partners?		Plasma Membrane System Process Regulation Of System Process Membrane G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Blood Circulation Circulatory System Process Vascular Process In Circulatory System Monoatomic Ion Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Blood Vessel Diameter Maintenance Regulation Of Tube Size Basolateral Plasma Membrane Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Transmembrane Transport Muscle Contraction Inorganic Ion Transmembrane Transport Metal Ion Transport Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Cardiac Muscle Cell Action Potential Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Muscle System Process Synapse Inward Rectifier Potassium Channel Activity Synaptic Signaling Vasodilation Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Adrenergic Receptor Activity CGMP-mediated Signaling Calcium-mediated Signaling Action Potential Potassium Ion Transport Regulation Of Blood Pressure Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Voltage-gated Sodium Channel Complex Signal Transduction Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organismal Process	Regulation Of Membrane Potential Transmembrane Transporter Binding Proline-rich Region Binding Protein-containing Complex Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Tube Morphogenesis Negative Regulation Of Cation Transmembrane Transport Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Mesenchyme Development Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Sodium Ion Transport Formation Of Structure Involved In A Symbiotic Process Neuromuscular Junction Negative Regulation Of Core Promoter Binding PDZ Domain Binding ATPase Binding Embryonic Heart Tube Morphogenesis Enterocyte Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Monoatomic Ion Transport Regulation Of Heart Rate Negative Regulation Of Transmembrane Transport Negative Regulation Of RNA Metabolic Process Channel Inhibitor Activity Sarcolemma Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Epithelial Tube Morphogenesis Cajal-Retzius Cell Differentiation Regulation Of Nucleocytoplasmic Transport Transcription Coregulator Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Import Into Cell Regulation Of Transport Response To Calcium Ion Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Intracellular Transport Phosphothreonine Residue Binding Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding TEAD-YAP Complex Regulation Of Cell Projection Organization Negative Regulation Of Transcription By RNA Polymerase III Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
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