SNTA1 and C3AR1

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)

		SNTA1	C3AR1
Description		syntrophin alpha 1	complement C3a receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Anchoring Junction	Plasma Membrane Membrane Azurophil Granule Membrane Specific Granule Membrane
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding ATPase Binding	Complement Receptor Activity Complement Component C3a Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity
	Biological Process	Regulation Of Heart Rate Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport	Complement Receptor Mediated Signaling Pathway Positive Regulation Of Immune System Process Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Calcium-mediated Signaling Complement Component C5a Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Neutrophil Chemotaxis
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Purinergic signaling in leishmaniasis infection Regulation of Complement cascade
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)	Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494)
Interacting Genes		76 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB ENTREP3 F8A1 FABP1 GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TIAM1 TLX3 TRA TRBV12-3 UTRN VANGL2 XRCC6	3 interacting genes: C3 C4A SNTA1
Entrez ID		6640	719
HPRD ID		03009	05581
Ensembl ID		ENSG00000101400	ENSG00000171860
Uniprot IDs		B3KTR0 Q13424	A8K2H7 Q16581
PDB IDs			8HK2 8HK3 8I95 8I97 8I9A 8I9L 8I9S 8IA8 8J6D 8JA3
Enriched GO Terms of Interacting Partners?		Plasma Membrane System Process Regulation Of System Process Membrane G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Blood Circulation Circulatory System Process Vascular Process In Circulatory System Monoatomic Ion Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Blood Vessel Diameter Maintenance Regulation Of Tube Size Basolateral Plasma Membrane Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Transmembrane Transport Muscle Contraction Inorganic Ion Transmembrane Transport Metal Ion Transport Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Cardiac Muscle Cell Action Potential Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Muscle System Process Synapse Inward Rectifier Potassium Channel Activity Synaptic Signaling Vasodilation Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Adrenergic Receptor Activity CGMP-mediated Signaling Calcium-mediated Signaling Action Potential Potassium Ion Transport Regulation Of Blood Pressure Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Voltage-gated Sodium Channel Complex Signal Transduction Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organismal Process	Classical-complement-pathway C3/C5 Convertase Complex Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Regulation Of Apoptotic Cell Clearance Positive Regulation Of Apoptotic Cell Clearance Opsonization Symbiont Cell Surface Antigen Binding Complement Activation, Classical Pathway Endopeptidase Inhibitor Activity Complement Activation Positive Regulation Of Phagocytosis Regulation Of Phagocytosis C5L2 Anaphylatoxin Chemotactic Receptor Binding Blood Microparticle Killing Of Cells Of Another Organism Positive Regulation Of Endocytosis Positive Regulation Of Activation Of Membrane Attack Complex Cell Killing Complement-dependent Cytotoxicity Vertebrate Eye-specific Patterning Oviduct Epithelium Development Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Complement-mediated Synapse Pruning Syntrophin Complex Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Endocytosis Protein Maturation Positive Regulation Of Complement Activation Positive Regulation Of Hypersensitivity Complement Binding Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Complement Component C1q Complex Binding Immune Effector Process Synapse Pruning Activation Of Immune Response Nitric-oxide Synthase Binding Neuron Remodeling Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Phagocytosis, Engulfment Complement Receptor Mediated Signaling Pathway Complement Activation, Alternative Pathway Regulation Of Acute Inflammatory Response To Antigenic Stimulus Dystrophin-associated Glycoprotein Complex Inflammatory Response Regulation Of Vesicle-mediated Transport Ventricular Cardiac Muscle Cell Action Potential
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