TGFA and SDCBP

Number of citations of the paper that reports this interaction (PMID 10230395)
29

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		TGFA	SDCBP
Gene Name		transforming growth factor, alpha	syndecan binding protein (syntenin)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Interleukin-5 Receptor Complex Adherens Junction Focal Adhesion Membrane Vesicle Melanosome Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Glycoprotein Binding Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Glycoprotein Binding Frizzled Binding Interleukin-5 Receptor Binding Protein Binding Protein C-terminus Binding Cytoskeletal Adaptor Activity Growth Factor Binding Neurexin Family Protein Binding Identical Protein Binding Protein Homodimerization Activity Syndecan Binding Ephrin Receptor Binding Protein Heterodimerization Activity Protein N-terminus Binding Cell Adhesion Molecule Binding
	Biological Process	Activation Of MAPK Activity Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Wound Healing Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation Mammary Gland Alveolus Development	Protein Targeting To Membrane Substrate-dependent Cell Migration, Cell Extension Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Actin Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Vesicular Exosome Assembly
Pathways			Ephrin signaling Axon guidance Neurofascin interactions EPH-Ephrin signaling L1CAM interactions
Drugs
Diseases
GWAS		Longevity ( 20834067) Neutrophil count ( 21507922) Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: ADAM10 ADAM17 EGFR ELANE ERBB2 ERBB4 GORASP1 GORASP2 MAGI2 MAGI3 NKD2 RHBDF1 SDCBP SGTA SNTA1	167 interactors: ABI2 AES ANKRD40 ANP32B APIP BCL2L15 C11orf57 C11orf68 C1orf109 CADM1 CADPS CALCOCO2 CBR3 CCDC102B CCDC36 CCDC53 CD6 CD63 CDA CDC34 CDCP1 CDIPT CEP55 CGGBP1 CLK2 CLK3 CMTM5 COX4I1 CRYAA CT45A3 CT45A5 CUTC DAK DCTD DCTPP1 DMC1 DTNBP1 EAF1 EDARADD EFNB1 EFNB2 EIF1AD EIF5A2 ELAVL1 ENOX1 EPHB2 ERICH2 FAM118A FAM118B FAM9B FLAD1 FOXP2 FTH1 FTL GNMT GPATCH11 GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRM3 HIVEP1 HMGB3 HNRNPC HOMEZ HOXA1 HPRT1 HSBP1 IKZF1 IL5RA INO80E KCNH1 KCTD1 KCTD6 KCTD9 KHDRBS2 KLHL12 KLHL2 KRTAP10-3 KRTAP10-7 KRTAP5-9 LDOC1 LGALS2 LSM6 LZTFL1 MAD2L1 MAPRE3 MBD3 MED4 MID2 MRFAP1L1 MTUS2 NADK NAGK NECAB2 NF2 NFASC NOTCH2NL NT5C2 OSTF1 PDCD6IP PDE4DIP PHC2 PNMA1 PNMA2 PRPF38A PRPF40A PRR13 PSMC6 PSTPIP1 PTPRJ PTS PUF60 PYCRL RAB5A RBM39 REEP6 REL RIC8A RNF11 RNH1 ROPN1 RP9P RTN1 RUNDC3A SDC1 SDC2 SDC4 SDCBP2 SDCCAG3 SEPT3 SET SIAH1 SLC6A5 SMARCA2 SOX4 SREK1IP1 SRSF11 SRSF7 SSNA1 STX1A SULT1B1 TDO2 TEKT1 TFCP2 TGFA THG1L TIFA TMEM239 TNFAIP8 TRAF5 TRIM27 TRIM32 TRIM38 TRIM54 UBE2A ULK1 WASL WDR91 ZBTB14 ZBTB8A ZCCHC10 ZCCHC17
Entrez ID		7039	6386
HPRD ID		07522	03741
Ensembl ID		ENSG00000163235	ENSG00000137575
Uniprot IDs		E7EPT6 F8VNR3 P01135	B4DHN5 G5EA09 O00560
PDB IDs		1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF	1N99 1NTE 1OBX 1OBY 1OBZ 1R6J 1V1T 1W9E 1W9O 1W9Q 1YBO
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Locomotion Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component PMA-inducible Membrane Protein Ectodomain Proteolysis Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Movement Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Proliferation Cell Migration Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Collagen Catabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Growth Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of T Cell Chemotaxis Regulation Of Cell Proliferation Collagen Metabolic Process Regulation Of ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Multicellular Organismal Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Generation Of Neurons Regulation Of Cell Migration Multicellular Organismal Metabolic Process	Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Neuron-neuron Synaptic Transmission Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Synaptic Transmission Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Homooligomerization Positive Regulation Of Exocytosis Protein Tetramerization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cellular Metabolic Process Regulation Of Cellular Component Organization Protein Oligomerization Protein Homotetramerization Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Stimulus Cell-cell Signaling Regulation Of Synaptic Transmission Cellular Process Protein Complex Assembly Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Viral Release From Host Cell Gene Expression Positive Regulation Of Secretion Protein Ubiquitination Negative Regulation Of Cellular Metabolic Process RNA Splicing Protein Modification By Small Protein Conjugation Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Ephrin Receptor Signaling Pathway Regulation Of Exocytosis Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Nucleoside Metabolic Process Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Organelle Assembly Negative Regulation Of Synaptic Transmission RNA Biosynthetic Process Regulation Of Synaptic Transmission, Glutamatergic Protein Polyubiquitination
Tagcloud ?		alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfb3 thra1 transforming transmission trios utilizing	conversely datasets fak healing hepatocyte hgf il2rgamma immunofluorescence indication lethality matrigel mda melanoma melanomas metastases metastasizes metastatic migrate opposite pseudo scid syndecan syndecans syntenin triggered unrelated uveal warrants wound
Tagcloud (Difference) ?		alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfb3 thra1 transforming transmission trios utilizing	conversely datasets fak healing hepatocyte hgf il2rgamma immunofluorescence indication lethality matrigel mda melanoma melanomas metastases metastasizes metastatic migrate opposite pseudo scid syndecan syndecans syntenin triggered unrelated uveal warrants wound
Tagcloud (Intersection) ?