TGFA and ADAM17

Number of citations of the paper that reports this interaction (PMID 11823465)
95

Data Source:
HPRD (in vitro)

		TGFA	ADAM17
Gene Name		transforming growth factor, alpha	ADAM metallopeptidase domain 17
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Cell Surface Actin Cytoskeleton Membrane Apical Plasma Membrane Ruffle Membrane Membrane Raft
	Molecular Function	Glycoprotein Binding Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Metalloendopeptidase Activity Notch Binding Interleukin-6 Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding PDZ Domain Binding
	Biological Process	Activation Of MAPK Activity Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Wound Healing Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation Mammary Gland Alveolus Development	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Neutrophil Mediated Immunity Germinal Center Formation Positive Regulation Of Leukocyte Chemotaxis Proteolysis Membrane Protein Ectodomain Proteolysis Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Cell Proliferation Positive Regulation Of T Cell Chemotaxis Extracellular Matrix Disassembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Collagen Catabolic Process Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Response To Lipopolysaccharide Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Epidermal Cells Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Response To Drug Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Neurotrophin TRK Receptor Signaling Pathway Spleen Development Cell Motility PMA-inducible Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cellular Component Movement Response To High Density Lipoprotein Particle JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Apoptotic Signaling Pathway
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Hedgehog ligand biogenesis TNF signaling Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Death Receptor Signalling Signaling by EGFRvIII in Cancer Degradation of the extracellular matrix Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Release of Hh-Np from the secreting cell Signaling by NOTCH1 Programmed Cell Death Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Regulated proteolysis of p75NTR Signalling by NGF Collagen degradation Signaling by NOTCH Processing-defective Hh variants abrogate ligand secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 Signaling by EGFR in Cancer Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Extrinsic Pathway Growth hormone receptor signaling
Drugs
Diseases
GWAS		Longevity ( 20834067) Neutrophil count ( 21507922) Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: ADAM10 ADAM17 EGFR ELANE ERBB2 ERBB4 GORASP1 GORASP2 MAGI2 MAGI3 NKD2 RHBDF1 SDCBP SGTA SNTA1	14 interactors: DLG1 ERBB4 FHL2 MAD2L1 MAD2L2 NOTCH1 PTPN3 SH3D19 TGFA TIMP3 TNF TNFRSF1A TNFRSF1B TNFSF11
Entrez ID		7039	6868
HPRD ID		07522	04703
Ensembl ID		ENSG00000163235	ENSG00000151694
Uniprot IDs		E7EPT6 F8VNR3 P01135	B2RNB2 P78536
PDB IDs		1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF	1BKC 1ZXC 2A8H 2DDF 2FV5 2FV9 2I47 2M2F 2OI0 3B92 3CKI 3E8R 3EDZ 3EWJ 3G42 3KMC 3KME 3L0T 3L0V 3LE9 3LEA 3LGP 3O64
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Locomotion Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component PMA-inducible Membrane Protein Ectodomain Proteolysis Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Movement Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Proliferation Cell Migration Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Collagen Catabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Growth Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of T Cell Chemotaxis Regulation Of Cell Proliferation Collagen Metabolic Process Regulation Of ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Multicellular Organismal Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Generation Of Neurons Regulation Of Cell Migration Multicellular Organismal Metabolic Process	Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Proteolysis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Protein Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Gland Development Positive Regulation Of Phosphorylation Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Response To Tumor Necrosis Factor Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Negative Regulation Of APC-Cdc20 Complex Activity Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Kinase Activity Positive Regulation Of JAK-STAT Cascade Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Transferase Activity Regulation Of Cell Division Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Localization Positive Regulation Of Fever Generation Activation Of Protein Kinase Activity
Tagcloud ?		alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfb3 thra1 transforming transmission trios utilizing	anchored apma arguing betacellulin bzatp cd23 cd62 chimeras constitutive convertase cytoplasmic disintegrin dispensable domain ectodomain influences influx ionomycin metalloprotease metalloproteinase motif negatively pro retention shedding tgfalpha translationally transmembrane
Tagcloud (Difference) ?		alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfb3 thra1 transforming transmission trios utilizing	anchored apma arguing betacellulin bzatp cd23 cd62 chimeras constitutive convertase cytoplasmic disintegrin dispensable domain ectodomain influences influx ionomycin metalloprotease metalloproteinase motif negatively pro retention shedding tgfalpha translationally transmembrane
Tagcloud (Intersection) ?