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TGFA and ELANE
Number of citations of the paper that reports this interaction (PubMedID
15245434
)
0
Data Source:
HPRD
(in vitro)
TGFA
ELANE
Description
transforming growth factor alpha
elastase, neutrophil expressed
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Membrane
Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Basolateral Plasma Membrane
Clathrin-coated Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Perinuclear Region Of Cytoplasm
Extracellular Region
Extracellular Space
Cytoplasm
Golgi Apparatus
Cytosol
Cell Surface
Transcription Repressor Complex
Secretory Granule
Extracellular Matrix
Cytoplasmic Vesicle
Azurophil Granule Lumen
Specific Granule Lumen
Phagocytic Vesicle
Extracellular Exosome
Molecular Function
Signaling Receptor Binding
Epidermal Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Transmembrane Receptor Protein Tyrosine Kinase Activator Activity
Receptor Ligand Activity
Protease Binding
Transcription Corepressor Activity
Endopeptidase Activity
Serine-type Endopeptidase Activity
Protein Binding
Heparin Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Cytokine Binding
Biological Process
Angiogenesis
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Intracellular Signal Transduction
ERBB2-EGFR Signaling Pathway
Positive Regulation Of MAPK Cascade
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Cell Division
Mammary Gland Alveolus Development
Hepatocyte Proliferation
Negative Regulation Of Transcription By RNA Polymerase II
Response To Yeast
Acute Inflammatory Response To Antigenic Stimulus
Leukocyte Migration Involved In Inflammatory Response
Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria
Proteolysis
Intracellular Calcium Ion Homeostasis
Phagocytosis
Response To UV
Extracellular Matrix Disassembly
Protein Catabolic Process
Response To Lipopolysaccharide
Negative Regulation Of Chemokine Production
Negative Regulation Of Interleukin-8 Production
Positive Regulation Of Interleukin-8 Production
Defense Response To Bacterium
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Inflammatory Response
Positive Regulation Of Immune Response
Defense Response To Fungus
Leukocyte Migration
Negative Regulation Of Chemotaxis
Pyroptotic Inflammatory Response
Neutrophil-mediated Killing Of Gram-negative Bacterium
Neutrophil-mediated Killing Of Fungus
Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways
PIP3 activates AKT signaling
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
COPII-mediated vesicle transport
EGFR interacts with phospholipase C-gamma
Constitutive Signaling by Aberrant PI3K in Cancer
Inhibition of Signaling by Overexpressed EGFR
RAF/MAP kinase cascade
Cargo concentration in the ER
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Extra-nuclear estrogen signaling
Estrogen-dependent gene expression
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Myoepithelial Cells
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Pyroptosis
Neutrophil degranulation
Antimicrobial peptides
Regulation of Complement cascade
Expression of NOTCH2NL genes
Drugs
Alpha-1-proteinase inhibitor
Mdl 101,146
Freselestat
Elafin
Lupeol
Ursolic acid
Diseases
Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
Gastric cancer
Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS
Acne (severe) (
24927181
)
Cough in response to angiotensin-converting enzyme inhibitor drugs (
28084903
)
Hair shape (
29220522
)
Hand grip strength (
29691431
29313844
)
Heel bone mineral density (
30598549
)
Hip minimal joint space width (
27701424
)
Longevity (
20834067
)
Low hand grip strength (60 years and older) (EWGSOP) (
33510174
)
Low hand grip strength (60 years and older) (FNIH) (
33510174
)
Neutrophil count (
21507922
)
Obesity-related traits (
23251661
)
Osteoarthritis (
30664745
)
Pulse pressure in young-onset hypertension (
24892410
)
Response to citalopram or escitalopram in depression (
27622933
)
Response to esketamine in treatment resistant depression (
32724131
)
Severe progression in rheumatoid arthritis (
29065906
)
Superior frontal gyrus grey matter volume (
25335168
)
Blood protein levels (
30072576
)
Interacting Genes
17 interacting genes:
ADAM10
ADAM17
EGFR
ELANE
ERBB2
ERBB4
GORASP1
GORASP2
LEPROTL1
MAGI2
MAGI3
NKD2
RHBDD1
RHBDF1
SDCBP
SGTA
SNTA1
31 interacting genes:
ACE2
CAMP
CSF3
CSF3R
CXCL12
CXCR4
ELN
F2R
F2RL1
F5
GRN
ITGAM
KNG1
LPA
LRP1
NOTCH2NLA
SDC1
SERPINA1
SERPINA3
SERPINB1
SERPINB13
SERPIND1
SERPINE1
SERPINF2
SERPING1
SLPI
TFPI
TGFA
THBS1
VCAM1
YARS1
Entrez ID
7039
1991
HPRD ID
07522
00554
Ensembl ID
ENSG00000163235
ENSG00000197561
Uniprot IDs
E7EPT6
F8VNR3
P01135
P08246
PDB IDs
1GK5
1MOX
1YUF
1YUG
2TGF
3E50
3TGF
4TGF
5KN5
7SZ5
7SZ7
1B0F
1H1B
1HNE
1PPF
1PPG
2RG3
2Z7F
3Q76
3Q77
4NZL
4WVP
5A09
5A0A
5A0B
5A0C
5A8X
5A8Y
5A8Z
5ABW
6E69
6F5M
6SMA
7CBK
7WHU
8D4Q
8D4U
8D7I
8D7K
8G24
8G25
8G26
8QGX
8VK5
9ASS
9ASX
9ATK
9ATU
Enriched GO Terms of Interacting Partners
?
Localization Within Membrane
Positive Regulation Of Growth
Positive Regulation Of Cell Growth
Cellular Localization
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Endopeptidase Activity
Establishment Of Protein Localization To Membrane
ERBB2 Signaling Pathway
Epidermal Growth Factor Receptor Activity
Positive Regulation Of Phosphorylation
Membrane
Membrane Protein Proteolysis
Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell Population Proliferation
ERBB2-ERBB4 Signaling Pathway
Positive Regulation Of Phosphate Metabolic Process
Growth Factor Binding
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Cell Population Proliferation
Regulation Of Growth
Transmembrane Receptor Protein Tyrosine Kinase Activity
Response To Epidermal Growth Factor
Regulation Of Cell Migration
Regulation Of Signal Transduction
Golgi Membrane
Regulation Of Protein Catabolic Process
Metallodipeptidase Activity
ERBB2-EGFR Signaling Pathway
Regulation Of Cell Motility
Regulation Of Cell Growth
ERBB4 Signaling Pathway
Basal Plasma Membrane
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Locomotion
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Phosphorylation
Regulation Of ERBB Signaling Pathway
Positive Regulation Of MAPK Cascade
Neuromuscular Junction
Positive Regulation Of Protein Phosphorylation
ATPase Binding
Regulation Of Cell Communication
Regulation Of Signaling
Basolateral Plasma Membrane
Positive Regulation Of T Cell Chemotaxis
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of T Cell Chemotaxis
Extracellular Region
Peptidase Inhibitor Activity
Extracellular Space
Serine-type Endopeptidase Inhibitor Activity
Endopeptidase Inhibitor Activity
Platelet Alpha Granule Lumen
Regulation Of Blood Coagulation
Regulation Of Hemostasis
Regulation Of Body Fluid Levels
Circulatory System Process
Blood Coagulation
Coagulation
Hemostasis
Regulation Of Response To Wounding
Extracellular Exosome
Extracellular Matrix
Regulation Of Wound Healing
Defense Response
Blood Circulation
Inflammatory Response
Negative Regulation Of Blood Coagulation
Negative Regulation Of Hemostasis
Negative Regulation Of Coagulation
Protease Binding
Regulation Of Biological Quality
Cell Surface
Positive Regulation Of Blood Coagulation
Negative Regulation Of Wound Healing
Negative Regulation Of Proteolysis
Negative Regulation Of Plasminogen Activation
Positive Regulation Of Coagulation
Regulation Of Multicellular Organismal Process
Chronic Inflammatory Response
Endoplasmic Reticulum Lumen
Positive Regulation Of Vasculature Development
Regulation Of Systemic Arterial Blood Pressure
Negative Regulation Of Fibrinolysis
Immune System Process
External Side Of Plasma Membrane
Positive Regulation Of Cell Population Proliferation
Regulation Of Fibrinolysis
Regulation Of Plasminogen Activation
Regulation Of Proteolysis
System Process
Positive Regulation Of Interleukin-8 Production
Fibrinolysis
Signaling Receptor Binding
Positive Regulation Of Wound Healing
Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure
Positive Regulation Of Reactive Oxygen Species Metabolic Process
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