SNTA1 and SCN4A

Number of citations of the paper that reports this interaction (PubMedID 9412493)
64

Data Source:
BioGRID (unspecified method)
HPRD (in vivo)

		SNTA1	SCN4A
Description		syntrophin alpha 1	sodium voltage-gated channel alpha subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Anchoring Junction	Voltage-gated Sodium Channel Complex Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding ATPase Binding	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding
	Biological Process	Regulation Of Heart Rate Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport	Action Potential Monoatomic Ion Transport Sodium Ion Transport Muscle Contraction Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Skeletal Muscle Contraction By Action Potential
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Topiramate Lidocaine Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Chloroprocaine Flecainide Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Parachlorophenol Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	Congenital myasthenic syndrome Hyperkalemic periodic paralysis (HyperPP) Hypokalemic periodic paralysis (HypoPP) Paramyotonia congenita (PMC) Potassium-aggravated myotonias (PAMs), including: Myotonia fluctuans; Myotonia permanens; Acetazolamide responsive myotonia
GWAS		HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)	Height ( 28552196 31562340) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		76 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB ENTREP3 F8A1 FABP1 GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TIAM1 TLX3 TRA TRBV12-3 UTRN VANGL2 XRCC6	10 interacting genes: CALM1 DLG1 DLG2 DLG3 ERBIN NHERF1 PATJ SNTA1 SNTB1 SNTB2
Entrez ID		6640	6329
HPRD ID		03009	04912
Ensembl ID		ENSG00000101400	ENSG00000007314
Uniprot IDs		B3KTR0 Q13424	P35499
PDB IDs			6AGF 6MBA 6MC9
Enriched GO Terms of Interacting Partners?		Plasma Membrane System Process Regulation Of System Process Membrane G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Blood Circulation Circulatory System Process Vascular Process In Circulatory System Monoatomic Ion Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Blood Vessel Diameter Maintenance Regulation Of Tube Size Basolateral Plasma Membrane Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Transmembrane Transport Muscle Contraction Inorganic Ion Transmembrane Transport Metal Ion Transport Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Cardiac Muscle Cell Action Potential Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Muscle System Process Synapse Inward Rectifier Potassium Channel Activity Synaptic Signaling Vasodilation Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Adrenergic Receptor Activity CGMP-mediated Signaling Calcium-mediated Signaling Action Potential Potassium Ion Transport Regulation Of Blood Pressure Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Voltage-gated Sodium Channel Complex Signal Transduction Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organismal Process	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Neuromuscular Junction Anchoring Junction Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Dystrophin-associated Glycoprotein Complex Ionotropic Glutamate Receptor Binding Plasma Membrane Receptor Localization To Synapse Receptor Clustering Phosphatase Binding Protein Localization To Synapse Basolateral Plasma Membrane Regulation Of Sodium Ion Transport GMP Kinase Activity PDZ Domain Binding Protein Localization To Cell Junction GDP Metabolic Process Protein Localization To Membrane Kinase Binding Postsynaptic Density Membrane Regulation Of Metal Ion Transport Sarcolemma Bicellular Tight Junction Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Protein Kinase Binding Regulation Of Cardiac Muscle Cell Action Potential GMP Metabolic Process Structural Molecule Activity Regulation Of Biological Quality Adherens Junction Localization Within Membrane Calmodulin Binding Regulation Of Heart Contraction Cell Junction Muscle Contraction Regulation Of System Process Regulation Of Sodium Ion Transmembrane Transport Regulation Of Blood Circulation Sperm Midpiece Muscle System Process Regulation Of Monoatomic Cation Transmembrane Transport Tight Junction Assembly Tight Junction Organization Regulation Of Action Potential
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