WIZ and EHMT2

Number of citations of the paper that reports this interaction (PMID 16702210)
24

Data Source:
HPRD (in vivo)

		WIZ	EHMT2
Gene Name		widely interspaced zinc finger motifs	euchromatic histone-lysine N-methyltransferase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Extracellular Vesicular Exosome	Nuclear Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding Metal Ion Binding SET Domain Binding	P53 Binding Protein Binding Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding
	Biological Process	Positive Regulation Of Nuclear Cell Cycle DNA Replication Protein Stabilization Protein Heterotrimerization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Replication DNA Methylation Chromatin Organization Histone Methylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Histone H3-K9 Methylation Histone H3-K27 Methylation
Pathways			Chromatin modifying enzymes Chromatin organization RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation PKMTs methylate histone lysines RNA Polymerase I Promoter Clearance Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs
Diseases
GWAS			Chronic hepatitis B infection ( 23760081) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239)
Protein-Protein Interactions		14 interactors: C8orf33 CDKN1A EHMT1 EHMT2 OSGEP PIN1 RCC1 RPP14 RPS10 SMN1 SUV39H1 SUV39H2 TK1 TSC22D1	42 interactors: C10orf12 CACNA1A CBX1 CCDC33 CHCHD2 CUX1 DNMT3A E4F1 ESR1 FAM161A H3F3B HGS HIST1H1A HIST1H1B HIST1H3A HIST2H3A HIST2H3C HIST3H3 ITGB5 KLF12 KLF3 KLF6 LIMS1 LMO2 LNX1 MX2 NAA10 NAPRT PLOD3 PRRC2B PSMA1 RD3 RELB RERE RUVBL2 THAP7 TP53 WIZ XAGE2 ZBTB38 ZNF512B ZNF785
Entrez ID		58525	10919
HPRD ID		11686	06854
Ensembl ID		ENSG00000011451	ENSG00000204371
Uniprot IDs		B3KVH1 M0QXA7 O95785	A2ABF8 A2ABF9 Q96KQ7
PDB IDs			2O8J 3DM1 3K5K 3RJW
Enriched GO Terms of Interacting Partners?		Peptidyl-lysine Dimethylation Histone H3-K9 Methylation Histone H3-K9 Modification Histone Lysine Methylation Peptidyl-lysine Methylation Histone Methylation Protein Methylation Histone H3-K9 Dimethylation Peptidyl-lysine Modification Histone H3-K9 Trimethylation Histone H3-K27 Methylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cell Cycle Histone Modification Negative Regulation Of Circadian Rhythm Methylation Nitrogen Compound Metabolic Process Peptidyl-lysine Trimethylation Peptidyl-amino Acid Modification NcRNA Metabolic Process Regulation Of Gene Expression, Epigenetic Chromatin Modification Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Chromatin Organization DNA Methylation Fetal Process Involved In Parturition Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process DNA Modification Threonylcarbamoyladenosine Biosynthetic Process Skeletal Muscle Cell Proliferation Regulation Of Circadian Rhythm Regulation Of Mitotic Cell Cycle Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Chromosome Organization Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Process DNA Methylation On Cytosine Within A CG Sequence Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Digestive Tract Development Threonylcarbamoyladenosine Metabolic Process	DNA Methylation On Cytosine Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Silencing Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Silencing At RDNA DNA Methylation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Conformation Change Regulation Of Metabolic Process Chromosome Organization DNA Modification DNA Packaging Transcription, DNA-templated Gene Silencing RNA Biosynthetic Process Chromatin Organization Chromatin Assembly Chromatin Assembly Or Disassembly Positive Regulation Of Gene Expression Cellular Component Assembly Regulation Of Gene Expression, Epigenetic DNA Metabolic Process Establishment Of Protein Localization To Chromatin RNA Metabolic Process Nucleosome Assembly Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleosome Organization Cellular Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Protein-DNA Complex Assembly Organelle Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated
Tagcloud ?		ankyrin asd autism autistic ba21 ba40 boundaries brodmann delays dimethylation dorn ehmt1 ehmt2 g9a glp h3k9 heteromeric intellectual kleefstra lys968arg methyltransferases nonsynonymous novelty postmortem prioritized raphe restrictive surmise thr961ile	availability biosensor bix01294 chaetocin codc enables expedite fluc2 g4s h3 h4 imaging k9 live lysine mark methylation methylations methyltransferase monitor nude pace preclinical replacement reveals sensor suv39h1 treating utility
Tagcloud (Difference) ?		ankyrin asd autism autistic ba21 ba40 boundaries brodmann delays dimethylation dorn ehmt1 g9a glp h3k9 heteromeric intellectual kleefstra lys968arg methyltransferases nonsynonymous novelty postmortem prioritized raphe restrictive surmise thr961ile	availability biosensor bix01294 chaetocin codc enables expedite fluc2 g4s h3 h4 imaging k9 live lysine mark methylation methylations methyltransferase monitor nude pace preclinical replacement reveals sensor suv39h1 treating utility
Tagcloud (Intersection) ?		ehmt2