Wiki-Pi
About
Search
People
Updates
Search
WNK1 and KLHL2
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method)
WNK1
KLHL2
Description
WNK lysine deficient protein kinase 1
kelch like family member 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Spindle
Cytosol
Cytoskeleton
Membrane
Protein-containing Complex
Intracellular Membraneless Organelle
Mitotic Spindle
Ruffle
Cytoplasm
Cytosol
Cytoskeleton
Actin Cytoskeleton
Lamellipodium
Cul3-RING Ubiquitin Ligase Complex
Cell Projection
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Phosphatase Binding
Protein Kinase Activator Activity
Protein Serine Kinase Activity
Molecular Condensate Scaffold Activity
Actin Binding
Protein Binding
Identical Protein Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Biological Process
Regulation Of Sodium Ion Transport
Positive Regulation Of Systemic Arterial Blood Pressure
Protein Phosphorylation
Monoatomic Ion Transport
Cell Volume Homeostasis
DNA Damage Response
Signal Transduction
Heart Development
Regulation Of Blood Pressure
Negative Regulation Of Autophagy
Negative Regulation Of Sodium Ion Transport
Regulation Of MRNA Export From Nucleus
Positive Regulation Of T Cell Chemotaxis
Intracellular Chloride Ion Homeostasis
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Cell-cell Adhesion Mediated By Integrin
Negative Regulation Of Heterotypic Cell-cell Adhesion
Intracellular Signal Transduction
Sodium Ion Transmembrane Transport
Chemokine (C-C Motif) Ligand 21 Signaling Pathway
Homeostatic Process
Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence
Positive Regulation Of Angiogenesis
Neuron Development
T Cell Receptor Signaling Pathway
Negative Regulation Of Small GTPase Mediated Signal Transduction
Potassium Ion Homeostasis
Monoatomic Cation Homeostasis
Cellular Hyperosmotic Response
Potassium Ion Transmembrane Transport
Negative Regulation Of Pancreatic Juice Secretion
Positive Regulation Of Canonical Wnt Signaling Pathway
Lymphocyte Migration Into Lymph Node
Membraneless Organelle Assembly
Regulation Of Sodium Ion Transmembrane Transport
Negative Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Mitotic Cytokinesis
Regulation Of Monoatomic Cation Transmembrane Transport
Positive Regulation Of Termination Of RNA Polymerase II Transcription
Cellular Response To Chemokine
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Stimuli-sensing channels
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS
Adult body size (
32376654
)
Body mass index (
25673413
29273807
)
Body size at age 10 (
32376654
)
Eosinophil count (
27863252
)
Eosinophil percentage of white cells (
27863252
)
Lung cancer (
28604730
)
Lung cancer in ever smokers (
28604730
)
Manganese levels (
26025379
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Squamous cell lung carcinoma (
28604730
)
Stroke (
19369658
)
Cognitive function (
24684796
)
General cognitive ability (
29844566
)
Neuroticism (
27067015
)
Interacting Genes
36 interacting genes:
ADRB2
AKT1
ARAF
ATXN1
BAG3
CLTC
COPS5
CSDE1
E2F3
FHL3
FLNC
GLIS2
KLHL2
MAP2K1
MAP3K2
MAP3K3
MT-ATP8
OXSR1
PFKP
PRKAR1A
PRKAR1B
PVR
RANBP9
SLC9A1
SYT2
TNRC6A
TSC22D1
TULP3
UBE2I
UPF2
WNK2
YWHAE
YWHAG
YWHAZ
ZNF106
ZYX
29 interacting genes:
ACTC1
BCAM
BYSL
CCDC43
CDC37
CIMIP1
CLK2
CWC22
ELOA
KLHL12
MFAP1
NAP1L2
NTAQ1
PADI6
PIBF1
POLR3C
SDCBP
TBKBP1
TMA16
TNPO2
TRIM50
TXNDC12
UBE2C
UBE2D1
UBE2I
UCK1
WNK1
WNK4
ZNF114
Entrez ID
65125
11275
HPRD ID
05570
09311
Ensembl ID
ENSG00000060237
ENSG00000109466
Uniprot IDs
A5D8Z4
F5GWT4
Q9H4A3
B4DFZ5
E9PEX9
O95198
PDB IDs
4PWN
5TF9
5WDY
5WE8
6FBK
2XN4
4CHB
Enriched GO Terms of Interacting Partners
?
Cytoplasm
Cytosol
Focal Adhesion
MAPK Cascade
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Serine Kinase Activity
Enzyme Binding
Response To Temperature Stimulus
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Signal Transduction
Kinase Activity
Intracellular Signal Transduction
Establishment Of Localization In Cell
Insulin-like Growth Factor Receptor Signaling Pathway
Intracellular Signaling Cassette
Phosphoserine Residue Binding
Protein Kinase Activity
Regulation Of Protein Localization
Positive Regulation Of Toll-like Receptor Signaling Pathway
CAMP-dependent Protein Kinase Regulator Activity
Negative Regulation Of Immune System Process
Ciliary Base
Protein Sequestering Activity
Regulation Of CAMP/PKA Signal Transduction
Intracellular Transport
Protein Autophosphorylation
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Binding
Identical Protein Binding
Nuclear Transport
Nucleocytoplasmic Transport
RNA Binding
CAMP-dependent Protein Kinase Complex
CAMP-dependent Protein Kinase Inhibitor Activity
ERK1 And ERK2 Cascade
Regulation Of Membrane Potential
Regulation Of TOR Signaling
Positive Regulation Of Signal Transduction
Regulation Of Protein Localization To Nucleus
Protein Kinase Binding
TORC1 Signaling
Negative Regulation Of Pancreatic Juice Secretion
Intracellular Chloride Ion Homeostasis
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?