WNK1 and MAP2K1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		WNK1	MAP2K1
Description		WNK lysine deficient protein kinase 1	mitogen-activated protein kinase kinase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Membrane Protein-containing Complex Intracellular Membraneless Organelle Mitotic Spindle	Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Focal Adhesion Cell Cortex Postsynaptic Density Membrane Axon Dendrite Dendrite Cytoplasm Ciliary Basal Body Perikaryon Perinuclear Region Of Cytoplasm Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Phosphatase Binding Protein Kinase Activator Activity Protein Serine Kinase Activity Molecular Condensate Scaffold Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Kinase Activator Activity Small GTPase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding Scaffold Protein Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Sodium Ion Transport Positive Regulation Of Systemic Arterial Blood Pressure Protein Phosphorylation Monoatomic Ion Transport Cell Volume Homeostasis DNA Damage Response Signal Transduction Heart Development Regulation Of Blood Pressure Negative Regulation Of Autophagy Negative Regulation Of Sodium Ion Transport Regulation Of MRNA Export From Nucleus Positive Regulation Of T Cell Chemotaxis Intracellular Chloride Ion Homeostasis Negative Regulation Of Protein Ubiquitination Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Sodium Ion Transmembrane Transport Chemokine (C-C Motif) Ligand 21 Signaling Pathway Homeostatic Process Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Positive Regulation Of Angiogenesis Neuron Development T Cell Receptor Signaling Pathway Negative Regulation Of Small GTPase Mediated Signal Transduction Potassium Ion Homeostasis Monoatomic Cation Homeostasis Cellular Hyperosmotic Response Potassium Ion Transmembrane Transport Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Membraneless Organelle Assembly Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinesis Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Termination Of RNA Polymerase II Transcription Cellular Response To Chemokine	MAPK Cascade Regulation Of Vascular Associated Smooth Muscle Contraction Chemotaxis Response To Oxidative Stress Signal Transduction Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Schwann Cell Development Cerebellar Cortex Formation Central Nervous System Neuron Differentiation Neuron Differentiation Keratinocyte Differentiation Positive Regulation Of Cell Migration Thyroid Gland Development Melanosome Transport Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Homotypic Cell-cell Adhesion Endodermal Cell Differentiation ERBB2-ERBB3 Signaling Pathway Myelination Positive Regulation Of MAPK Cascade Type B Pancreatic Cell Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Muscle Contraction Positive Regulation Of Ras Protein Signal Transduction Vesicle Transport Along Microtubule Insulin-like Growth Factor Receptor Signaling Pathway Golgi Inheritance Thymus Development Response To Axon Injury Regulation Of Axon Regeneration Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Axonogenesis Response To Glucocorticoid Bergmann Glial Cell Differentiation Face Development Lung Morphogenesis Trachea Formation Epithelial Cell Proliferation Involved In Lung Morphogenesis Placenta Blood Vessel Development Labyrinthine Layer Development Triglyceride Homeostasis ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Cellular Senescence Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Endodermal Cell Differentiation Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of ATP Biosynthetic Process
Pathways		Stimuli-sensing channels	MAPK3 (ERK1) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants
Drugs			K-252a 5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide Cobimetinib Bosutinib (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide Mirdametinib N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE Trametinib Selumetinib Pimasertib
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)	Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Adult body size ( 32376654) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Eosinophil count ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)	Prostate cancer ( 29892016) Testicular germ cell tumor ( 28604728 28604732)
Interacting Genes		36 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 OXSR1 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 TULP3 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX	67 interacting genes: APC ARAF AURKA BANP BAX BIRC6 BMPR1A BRAF BUB1 CASP9 CDH1 CDK5 CDKN2A CPNE1 CPNE4 CTNNA1 EGFR ELK1 EP300 ERBB2 FBXW7 GRB10 HNRNPD HRAS ITCH KAT7 KSR1 KSR2 LAMTOR3 MAP3K4 MAP3K8 MAPK1 MAPK14 MAPK3 MAPK8 MAPK8IP3 MBP MLH3 MSH6 MYC ODC1 PAK1 PARVA PDGFRL PEBP1 PEBP4 PIK3CA PLEKHF2 PLK3 PPARG PRKCI PRKCZ PTPRJ RAF1 RPS6KA2 RPS6KA4 SMAD2 SRC STK11 TCP11 TGFBR2 TLR2 TRAF3 TRAF6 TRIB1 UBE2I WNK1
Entrez ID		65125	5604
HPRD ID		05570	01469
Ensembl ID		ENSG00000060237	ENSG00000169032
Uniprot IDs		A5D8Z4 F5GWT4 Q9H4A3	A0A8I5KYS7 A4QPA9 B4DFY5 Q02750
PDB IDs		4PWN 5TF9 5WDY 5WE8 6FBK	1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81 5BX0 5EYM 5HZE 5YT3 6NYB 6PP9 6Q0J 6Q0T 6U2G 6V2W 6X2P 6X2S 6X2X 7B3M 7B7R 7B94 7B9L 7F2X 7M0T 7M0U 7M0V 7M0W 7M0X 7M0Y 7M0Z 7MFD 7PQV 7UMB 7XLP 7XNC 8CHF 8DGS 8DGT 8YP4 9AXA 9AXC 9AXH 9AXM 9AXX 9AXY 9AY7 9AYA
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Focal Adhesion MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine Kinase Activity Enzyme Binding Response To Temperature Stimulus Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Signal Transduction Kinase Activity Intracellular Signal Transduction Establishment Of Localization In Cell Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Phosphoserine Residue Binding Protein Kinase Activity Regulation Of Protein Localization Positive Regulation Of Toll-like Receptor Signaling Pathway CAMP-dependent Protein Kinase Regulator Activity Negative Regulation Of Immune System Process Ciliary Base Protein Sequestering Activity Regulation Of CAMP/PKA Signal Transduction Intracellular Transport Protein Autophosphorylation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Binding Identical Protein Binding Nuclear Transport Nucleocytoplasmic Transport RNA Binding CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity ERK1 And ERK2 Cascade Regulation Of Membrane Potential Regulation Of TOR Signaling Positive Regulation Of Signal Transduction Regulation Of Protein Localization To Nucleus Protein Kinase Binding TORC1 Signaling	Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Protein Serine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction MAPK Cascade ATP Binding Regulation Of Cell Communication Regulation Of Signaling Transferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Apoptotic Process Signal Transduction Regulation Of MAPK Cascade Programmed Cell Death Cell Death Intracellular Signaling Cassette Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Cytosol Regulation Of Cellular Localization Regulation Of Cell Population Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Protein Modification Process Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Animal Organ Development Regulation Of Cell Differentiation Phosphorylation Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cellular Component Organization Regulation Of Cell Development Enzyme-linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorylation Immune Response-activating Signaling Pathway
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