WNK1 and WNK2

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		WNK1	WNK2
Gene Name		WNK lysine deficient protein kinase 1	WNK lysine deficient protein kinase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Phosphatase Binding	Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Ion Transport Negative Regulation Of Phosphatase Activity Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Neuron Development Regulation Of Cellular Process	Protein Phosphorylation Negative Regulation Of Cell Proliferation Intracellular Signal Transduction Protein Autophosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Ion Homeostasis Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Ion channel transport Stimuli-sensing channels	Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: ADRB2 AKT1 ARAF ATP8 ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 MAP2K1 MAP3K2 MAP3K3 NEDD4L PFKP PRKAR1A PRKAR1B PVR RANBP9 RBX1 SLC9A1 SUMO1 SYT2 TNRC6A TSC22D1 UBC UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX	4 interactors: ATXN1 DGCR14 WNK1 YWHAZ
Entrez ID		65125	65268
HPRD ID		05570	06951
Ensembl ID		ENSG00000060237	ENSG00000165238
Uniprot IDs		A5D8Z4 F5GWT4 H6WZW3 Q9H4A3	F8W9F9 Q9Y3S1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Sodium Ion Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Activation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Intracellular Transport Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Sodium Ion Transport Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Growth Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Kinase Activity Response To Fibroblast Growth Factor Cellular Response To Peptide Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Kinase Activity Establishment Of Localization In Cell Signal Transduction Cell Communication Cellular Localization Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Intracellular Signal Transduction Positive Regulation Of Mitochondrion Organization Cellular Response To Organic Substance Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Phosphorylation Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process	Golgi Reassembly Negative Regulation Of Pancreatic Juice Secretion Histamine Secretion By Mast Cell Establishment Of Golgi Localization Golgi Inheritance Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Histamine Secretion Negative Regulation Of Phosphorylation Histamine Transport Positive Regulation Of Systemic Arterial Blood Pressure Golgi Localization Mast Cell Degranulation RNA Processing Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Mast Cell Mediated Immunity Lysosome Localization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mast Cell Activation Cytoplasmic Transport Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Leukocyte Degranulation Positive Regulation Of Blood Pressure Regulated Secretory Pathway Peptidyl-threonine Phosphorylation Cell-cell Signaling
Tagcloud ?		alanine associate cation ccc cccs chloride compromise cotransporters disruption hence knock lens lenses maintain opacification osr1 proline rat regionally spak ste20 subcellular subcellularly susceptibility transcript transcriptase transparency wet	allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hist1h1c hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation
Tagcloud (Difference) ?		alanine associate cation ccc cccs chloride compromise cotransporters disruption hence knock lens lenses maintain opacification osr1 proline rat regionally spak ste20 subcellular subcellularly susceptibility transcript transcriptase transparency wet	allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hist1h1c hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation
Tagcloud (Intersection) ?