WNK1 and ATP8

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		WNK1	ATP8
Gene Name		WNK lysine deficient protein kinase 1	ATP synthase F0 subunit 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Phosphatase Binding
	Biological Process	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Ion Transport Negative Regulation Of Phosphatase Activity Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Neuron Development Regulation Of Cellular Process
Pathways		Ion channel transport Stimuli-sensing channels	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The citric acid (TCA) cycle and respiratory electron transport Formation of ATP by chemiosmotic coupling
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: ADRB2 AKT1 ARAF ATP8 ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 MAP2K1 MAP3K2 MAP3K3 NEDD4L PFKP PRKAR1A PRKAR1B PVR RANBP9 RBX1 SLC9A1 SUMO1 SYT2 TNRC6A TSC22D1 UBC UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX	4 interactors: GRB2 PACSIN1 RAPGEF2 WNK1
Entrez ID		65125	4509
HPRD ID		05570
Ensembl ID		ENSG00000060237
Uniprot IDs		A5D8Z4 F5GWT4 H6WZW3 Q9H4A3	P03928 Q85BD0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Sodium Ion Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Activation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Intracellular Transport Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Sodium Ion Transport Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Growth Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Kinase Activity Response To Fibroblast Growth Factor Cellular Response To Peptide Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Kinase Activity Establishment Of Localization In Cell Signal Transduction Cell Communication Cellular Localization Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Intracellular Signal Transduction Positive Regulation Of Mitochondrion Organization Cellular Response To Organic Substance Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Phosphorylation Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process	Neuron Development Neuron Differentiation Generation Of Neurons Neurogenesis Cell Development Nervous System Development Regulation Of Dendrite Development Neuron Projection Development Protein Localization To Plasma Membrane Negative Regulation Of Melanin Biosynthetic Process Cell Differentiation Cell Projection Organization Brain-derived Neurotrophic Factor Receptor Signaling Pathway Ras Protein Signal Transduction Plasma Membrane Organization Positive Regulation Of Neuron Projection Development Neurotrophin Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Regulation Of Phosphorylation Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Cell Projection Organization Regulation Of Phosphorus Metabolic Process System Development Establishment Of Endothelial Intestinal Barrier Cellular Response To CGMP Positive Regulation Of Neuron Differentiation Response To CGMP Negative Regulation Of Dendrite Morphogenesis Protein Localization To Membrane Rap Protein Signal Transduction Regulation Of Neuron Projection Development Negative Regulation Of Transport Branching Involved In Labyrinthine Layer Morphogenesis Multicellular Organismal Development Positive Regulation Of Neurogenesis Intracellular Signal Transduction Anatomical Structure Development Endomembrane System Organization Regulation Of Cellular Component Organization Positive Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Vasculogenesis Nerve Growth Factor Signaling Pathway Regulation Of CAMP-dependent Protein Kinase Activity Cellular Response To Organonitrogen Compound Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Neuron Migration Regulation Of Cell Projection Organization Microvillus Assembly
Tagcloud ?		alanine associate cation ccc cccs chloride compromise cotransporters disruption hence knock lens lenses maintain opacification osr1 proline rat regionally spak ste20 subcellular subcellularly susceptibility transcript transcriptase transparency wet	abolishing activators belongs chloroplasts coimmunoprecipitation cooperativity cox1 cytochrome deletion demonstrates disrupted entire entirely largest mitochondria motifs mrna mss51 oxidase pentatricopeptide pet309 polycistronic portion ppr predicts selectively translational undetectable utr
Tagcloud (Difference) ?		alanine associate cation ccc cccs chloride compromise cotransporters disruption hence knock lens lenses maintain opacification osr1 proline rat regionally spak ste20 subcellular subcellularly susceptibility transcript transcriptase transparency wet	abolishing activators belongs chloroplasts coimmunoprecipitation cooperativity cox1 cytochrome deletion demonstrates disrupted entire entirely largest mitochondria motifs mrna mss51 oxidase pentatricopeptide pet309 polycistronic portion ppr predicts selectively translational undetectable utr
Tagcloud (Intersection) ?