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WNK1 and FHL3
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
WNK1
FHL3
Description
WNK lysine deficient protein kinase 1
four and a half LIM domains 3
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Spindle
Cytosol
Cytoskeleton
Membrane
Protein-containing Complex
Intracellular Membraneless Organelle
Mitotic Spindle
Stress Fiber
Nucleus
Cytoplasm
Focal Adhesion
Z Disc
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Phosphatase Binding
Protein Kinase Activator Activity
Protein Serine Kinase Activity
Molecular Condensate Scaffold Activity
Transcription Coregulator Activity
Actin Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Biological Process
Regulation Of Sodium Ion Transport
Positive Regulation Of Systemic Arterial Blood Pressure
Protein Phosphorylation
Monoatomic Ion Transport
Cell Volume Homeostasis
DNA Damage Response
Signal Transduction
Heart Development
Regulation Of Blood Pressure
Negative Regulation Of Autophagy
Negative Regulation Of Sodium Ion Transport
Regulation Of MRNA Export From Nucleus
Positive Regulation Of T Cell Chemotaxis
Intracellular Chloride Ion Homeostasis
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Cell-cell Adhesion Mediated By Integrin
Negative Regulation Of Heterotypic Cell-cell Adhesion
Intracellular Signal Transduction
Sodium Ion Transmembrane Transport
Chemokine (C-C Motif) Ligand 21 Signaling Pathway
Homeostatic Process
Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence
Positive Regulation Of Angiogenesis
Neuron Development
T Cell Receptor Signaling Pathway
Negative Regulation Of Small GTPase Mediated Signal Transduction
Potassium Ion Homeostasis
Monoatomic Cation Homeostasis
Cellular Hyperosmotic Response
Potassium Ion Transmembrane Transport
Negative Regulation Of Pancreatic Juice Secretion
Positive Regulation Of Canonical Wnt Signaling Pathway
Lymphocyte Migration Into Lymph Node
Membraneless Organelle Assembly
Regulation Of Sodium Ion Transmembrane Transport
Negative Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Mitotic Cytokinesis
Regulation Of Monoatomic Cation Transmembrane Transport
Positive Regulation Of Termination Of RNA Polymerase II Transcription
Cellular Response To Chemokine
Muscle Organ Development
Actin Cytoskeleton Organization
Pathways
Stimuli-sensing channels
Drugs
Diseases
Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS
Adult body size (
32376654
)
Body mass index (
25673413
29273807
)
Body size at age 10 (
32376654
)
Eosinophil count (
27863252
)
Eosinophil percentage of white cells (
27863252
)
Lung cancer (
28604730
)
Lung cancer in ever smokers (
28604730
)
Manganese levels (
26025379
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Squamous cell lung carcinoma (
28604730
)
Stroke (
19369658
)
Coronary artery disease (
29212778
33020668
)
Pulse pressure (
30578418
)
Interacting Genes
36 interacting genes:
ADRB2
AKT1
ARAF
ATXN1
BAG3
CLTC
COPS5
CSDE1
E2F3
FHL3
FLNC
GLIS2
KLHL2
MAP2K1
MAP3K2
MAP3K3
MT-ATP8
OXSR1
PFKP
PRKAR1A
PRKAR1B
PVR
RANBP9
SLC9A1
SYT2
TNRC6A
TSC22D1
TULP3
UBE2I
UPF2
WNK2
YWHAE
YWHAG
YWHAZ
ZNF106
ZYX
181 interacting genes:
A1CF
ACTB
ADAM15
ADAMTSL4
AIMP2
AMBP
ANKHD1
ARHGEF10
ARID5A
ASCL4
BARX2
C1orf94
CASS4
CBX8
CCDC198
CCND3
CDC25B
CDC42EP1
CDKN1A
CDKN2D
CHEK2
CIMAP1B
CLCN2
CNNM3
CNOT7
CORO1A
CREB5
CRIP3
CRYBA2
CSF1
CTBP2
CYSRT1
DCDC2B
DLGAP4
DMRT3
DUX4L9
E2F8
EFCAB12
EIF4EBP2
EPHA10
EPM2AIP1
ERBB3
EXOSC1
EXOSC5
FADS6
FAM110A
FAM222B
FAM90A1
FBXL18
FHL2
FOS
FOSL2
FOXN4
GARIN6
GATA1
GATA2
GCM2
GUCD1
HAPLN2
HIPK1
HOXA1
HSF2BP
HYAL2
HYCC1
IHO1
IKZF3
ITGA7
ITGB5
KANK2
KIDINS220
KIRREL2
KLF12
KLF3
KLF8
KPRP
KRTAP12-1
KRTAP12-2
KTI12
LASP1
LATS2
LHB
LMO2
LMO4
LNX1
LNX2
MAPK1
MED15
MMP14
MORF4L1
MPZL1
MRM3
MRPL27
MRRF
MSRB3
MTA1
MTUS2
MYBPC1
MYBPHL
MYCBP2
MYOZ3
MYPOP
MZF1
NDUFAB1
NFKBIB
NPRL3
P4HA2
PAK5
PATL1
PHC2
PHF21A
PIAS1
PIERCE1
PKP2
PLEKHF2
PLEKHG4B
POLR1H
PPIG
PRR35
PRR5L
PTPN6
QKI
QRICH1
RAB40B
RAD21
RASL12
RBM42
RFX3
RFX6
RHEBL1
RSPH14
RYBP
SAP30BP
SAXO1
SAXO4
SBF2
SDCBP
SH3GLB2
SHE
SLAIN1
SLC25A46
SLC44A3
SLU7
SMAD2
SMAD3
SMAD4
SNRPB
SNRPC
SNRPG
SPATA8
SPMAP2
SREBF2
SRF
SRGN
SUPT5H
TBC1D22B
THAP7
TLE5
TMEM108
TMEM14B
TMSB4X
TMX3
TRAF3IP2
TRIM27
TRIP6
TRO
TSGA10IP
TTLL10
TUBA3E
TYK2
TYMSOS
UBE2I
UBE2Q1
VWC2L
WDR25
WNK1
YPEL3
ZCCHC14
ZFP36
ZNF417
ZNF512B
ZNF587
Entrez ID
65125
2275
HPRD ID
05570
09101
Ensembl ID
ENSG00000060237
ENSG00000183386
Uniprot IDs
A5D8Z4
F5GWT4
Q9H4A3
Q13643
Q96C98
PDB IDs
4PWN
5TF9
5WDY
5WE8
6FBK
1WYH
2CUQ
2EHE
Enriched GO Terms of Interacting Partners
?
Cytoplasm
Cytosol
Focal Adhesion
MAPK Cascade
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Serine Kinase Activity
Enzyme Binding
Response To Temperature Stimulus
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Signal Transduction
Kinase Activity
Intracellular Signal Transduction
Establishment Of Localization In Cell
Insulin-like Growth Factor Receptor Signaling Pathway
Intracellular Signaling Cassette
Phosphoserine Residue Binding
Protein Kinase Activity
Regulation Of Protein Localization
Positive Regulation Of Toll-like Receptor Signaling Pathway
CAMP-dependent Protein Kinase Regulator Activity
Negative Regulation Of Immune System Process
Ciliary Base
Protein Sequestering Activity
Regulation Of CAMP/PKA Signal Transduction
Intracellular Transport
Protein Autophosphorylation
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Binding
Identical Protein Binding
Nuclear Transport
Nucleocytoplasmic Transport
RNA Binding
CAMP-dependent Protein Kinase Complex
CAMP-dependent Protein Kinase Inhibitor Activity
ERK1 And ERK2 Cascade
Regulation Of Membrane Potential
Regulation Of TOR Signaling
Positive Regulation Of Signal Transduction
Regulation Of Protein Localization To Nucleus
Protein Kinase Binding
TORC1 Signaling
Protein Binding
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Ventral Spinal Cord Interneuron Differentiation
Negative Regulation Of Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Positive Regulation Of RNA Metabolic Process
Transcription Regulator Complex
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Chromatin Binding
Positive Regulation Of Biosynthetic Process
Regulation Of MiRNA Metabolic Process
Transcription Coregulator Binding
DNA-binding Transcription Factor Activity
Regulation Of Primary Metabolic Process
DNA Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of MiRNA Transcription
Phosphatase Binding
Positive Regulation Of Macromolecule Metabolic Process
Cell Population Proliferation
Cis-regulatory Region Sequence-specific DNA Binding
Positive Regulation Of MiRNA Transcription
Identical Protein Binding
SMAD Protein Complex
Sequence-specific Double-stranded DNA Binding
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Chromatin
Positive Regulation Of MiRNA Metabolic Process
Heteromeric SMAD Protein Complex
Myelination
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Axon Ensheathment
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