WNK1 and E2F3

Number of citations of the paper that reports this interaction (PubMedID 12748276)
56

Data Source:
BioGRID (two hybrid)

		WNK1	E2F3
Description		WNK lysine deficient protein kinase 1	E2F transcription factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Membrane Protein-containing Complex Intracellular Membraneless Organelle Mitotic Spindle	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Phosphatase Binding Protein Kinase Activator Activity Protein Serine Kinase Activity Molecular Condensate Scaffold Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Sodium Ion Transport Positive Regulation Of Systemic Arterial Blood Pressure Protein Phosphorylation Monoatomic Ion Transport Cell Volume Homeostasis DNA Damage Response Signal Transduction Heart Development Regulation Of Blood Pressure Negative Regulation Of Autophagy Negative Regulation Of Sodium Ion Transport Regulation Of MRNA Export From Nucleus Positive Regulation Of T Cell Chemotaxis Intracellular Chloride Ion Homeostasis Negative Regulation Of Protein Ubiquitination Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Sodium Ion Transmembrane Transport Chemokine (C-C Motif) Ligand 21 Signaling Pathway Homeostatic Process Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Positive Regulation Of Angiogenesis Neuron Development T Cell Receptor Signaling Pathway Negative Regulation Of Small GTPase Mediated Signal Transduction Potassium Ion Homeostasis Monoatomic Cation Homeostasis Cellular Hyperosmotic Response Potassium Ion Transmembrane Transport Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Membraneless Organelle Assembly Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinesis Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Termination Of RNA Polymerase II Transcription Cellular Response To Chemokine	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Import Into Nucleus Positive Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways		Stimuli-sensing channels	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence G2 Phase Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Adult body size ( 32376654) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Eosinophil count ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)	Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301) Estimated glomerular filtration rate in non-diabetics ( 31451708) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Metabolite levels ( 23823483) Molybdenum levels ( 26025379) Obesity-related traits ( 23251661) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006)
Interacting Genes		36 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 OXSR1 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 TULP3 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX	26 interacting genes: ATAD2 CCNA2 CCNF CDK3 DNMT3L FHL2 FZR1 HCFC1 HELLS MGA MYBL2 PKIB RB1 RCAN1 RNF144A RYBP SP1 SPIB SRA1 TEAD3 TFDP1 TFDP2 TFE3 UCHL5 WNK1 YY1
Entrez ID		65125	1871
HPRD ID		05570	02693
Ensembl ID		ENSG00000060237	ENSG00000112242
Uniprot IDs		A5D8Z4 F5GWT4 Q9H4A3	O00716
PDB IDs		4PWN 5TF9 5WDY 5WE8 6FBK
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Focal Adhesion MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine Kinase Activity Enzyme Binding Response To Temperature Stimulus Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Signal Transduction Kinase Activity Intracellular Signal Transduction Establishment Of Localization In Cell Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Phosphoserine Residue Binding Protein Kinase Activity Regulation Of Protein Localization Positive Regulation Of Toll-like Receptor Signaling Pathway CAMP-dependent Protein Kinase Regulator Activity Negative Regulation Of Immune System Process Ciliary Base Protein Sequestering Activity Regulation Of CAMP/PKA Signal Transduction Intracellular Transport Protein Autophosphorylation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Binding Identical Protein Binding Nuclear Transport Nucleocytoplasmic Transport RNA Binding CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity ERK1 And ERK2 Cascade Regulation Of Membrane Potential Regulation Of TOR Signaling Positive Regulation Of Signal Transduction Regulation Of Protein Localization To Nucleus Protein Kinase Binding TORC1 Signaling	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Division Chromatin Remodeling G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Organization Rb-E2F Complex Transcription Regulator Complex Cyclin-dependent Protein Kinase Holoenzyme Complex DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Mitotic Cell Cycle Phase Transition Anaphase-promoting Complex Binding Cell Cycle Phase Transition DNA Binding DNA-binding Transcription Factor Binding Positive Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance In Response To DNA Damage Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Ino80 Complex Regulation Of DNA Strand Elongation Response To Hormone Transcription Factor Binding Negative Regulation Of Calcium-mediated Signaling Regulation Of Chromosome Organization
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