WNK1 and PRKAR1A

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		WNK1	PRKAR1A
Description		WNK lysine deficient protein kinase 1	protein kinase cAMP-dependent type I regulatory subunit alpha
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GO Annotations	Cellular Component	Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Membrane Protein-containing Complex Intracellular Membraneless Organelle Mitotic Spindle	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Plasma Membrane Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Synapse Ciliary Base Glutamatergic Synapse Sperm Head-tail Coupling Apparatus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Phosphatase Binding Protein Kinase Activator Activity Protein Serine Kinase Activity Molecular Condensate Scaffold Activity	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Regulation Of Sodium Ion Transport Positive Regulation Of Systemic Arterial Blood Pressure Protein Phosphorylation Monoatomic Ion Transport Cell Volume Homeostasis DNA Damage Response Signal Transduction Heart Development Regulation Of Blood Pressure Negative Regulation Of Autophagy Negative Regulation Of Sodium Ion Transport Regulation Of MRNA Export From Nucleus Positive Regulation Of T Cell Chemotaxis Intracellular Chloride Ion Homeostasis Negative Regulation Of Protein Ubiquitination Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Sodium Ion Transmembrane Transport Chemokine (C-C Motif) Ligand 21 Signaling Pathway Homeostatic Process Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Positive Regulation Of Angiogenesis Neuron Development T Cell Receptor Signaling Pathway Negative Regulation Of Small GTPase Mediated Signal Transduction Potassium Ion Homeostasis Monoatomic Cation Homeostasis Cellular Hyperosmotic Response Potassium Ion Transmembrane Transport Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Membraneless Organelle Assembly Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinesis Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Termination Of RNA Polymerase II Transcription Cellular Response To Chemokine	Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Stimuli-sensing channels	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)	Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Adult body size ( 32376654) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Eosinophil count ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)	Body size at age 10 ( 32376654) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		36 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 OXSR1 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 TULP3 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX	55 interacting genes: AKAP1 AKAP10 AKAP11 AKAP19 AKAP4 AKAP5 AKAP7 AKT1 ARFGEF2 BAHD1 BTG3 CAPN11 CBS CCNE1 CDK2 CDK4 CSTPP1 DSCR4 DSCR9 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAP1A MAP1B MAPK6 MYO7A NELL2 OGT PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PSMG1 PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SNCA SPART TAB1 WDCP WNK1 YWHAZ ZBED1
Entrez ID		65125	5573
HPRD ID		05570	01786
Ensembl ID		ENSG00000060237	ENSG00000108946
Uniprot IDs		A5D8Z4 F5GWT4 Q9H4A3	B2R5T5 P10644
PDB IDs		4PWN 5TF9 5WDY 5WE8 6FBK	5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Focal Adhesion MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine Kinase Activity Enzyme Binding Response To Temperature Stimulus Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Signal Transduction Kinase Activity Intracellular Signal Transduction Establishment Of Localization In Cell Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Phosphoserine Residue Binding Protein Kinase Activity Regulation Of Protein Localization Positive Regulation Of Toll-like Receptor Signaling Pathway CAMP-dependent Protein Kinase Regulator Activity Negative Regulation Of Immune System Process Ciliary Base Protein Sequestering Activity Regulation Of CAMP/PKA Signal Transduction Intracellular Transport Protein Autophosphorylation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Binding Identical Protein Binding Nuclear Transport Nucleocytoplasmic Transport RNA Binding CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity ERK1 And ERK2 Cascade Regulation Of Membrane Potential Regulation Of TOR Signaling Positive Regulation Of Signal Transduction Regulation Of Protein Localization To Nucleus Protein Kinase Binding TORC1 Signaling	Protein Kinase A Regulatory Subunit Binding CAMP-dependent Protein Kinase Complex Protein Kinase A Binding Protein Phosphorylation Cytosol Phosphorylation Protein-containing Complex Ubiquitin Protein Ligase Binding Cytoplasm Peptidyl-serine Phosphorylation Regulation Of Protein Localization To Cell Periphery Protein Serine Kinase Activity Intracellular Signal Transduction Regulation Of Biological Quality Signal Transduction Kinase Activity Protein Kinase Activity Cyclin E1-CDK2 Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Serine/threonine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Regulation Of Lymphocyte Migration Intracellular Signaling Cassette Postsynapse Cellular Response To Oxygen-containing Compound Protein Kinase Binding Intracellular Protein Localization Protein Domain Specific Binding Cell Surface Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Localization To Cell Periphery ERBB Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process CAMP-dependent Protein Kinase Activity Establishment Of Protein Localization TOR Signaling Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of T Cell Migration Odontoblast Differentiation Regulation Of Protein Kinase A Signaling Organelle Organization Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Membrane Enzyme Binding
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