IRF5 and ALPI

Number of citations of the paper that reports this interaction (PubMedID 19786094)
0

Data Source:
BioGRID (pull down)

		IRF5	ALPI
Description		interferon regulatory factor 5	alkaline phosphatase, intestinal
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Sequence-specific DNA Binding Protein Serine/threonine Kinase Binding Sequence-specific Double-stranded DNA Binding	Magnesium Ion Binding Protease Binding Alkaline Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Phosphatase Activity Metal Ion Binding
	Biological Process	Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Cellular Response To Virus	Dephosphorylation
Pathways		Interferon gamma signaling Interferon alpha/beta signaling SLC15A4:TASL-dependent IRF5 activation	Synthesis of PA Post-translational modification: synthesis of GPI-anchored proteins Digestion
Drugs			Terpinen-4-ol
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Behcet's disease ( 33393726) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diffuse cutaneous systemic sclerosis ( 29293537) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) Limited cutaneous systemic scleroderma ( 29293537) Liver enzyme levels (alkaline phosphatase) ( 33972514) Primary biliary cholangitis ( 20639880 26394269 21399635) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30423114 24390342 23143596 30572963 21156761) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sjögren's syndrome ( 24097067 28076899) Systemic lupus erythematosus ( 26502338 28714469 32771030 27399966 33272962 26663301 18204098 18204446 19838193 19838195 21408207 23053960 23273568 26606652 24871463) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 24387989 20383147 31672989 21750679 30572963 21779181 30247649 29293537) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Ulcerative colitis ( 23128233 28067908 21297633 26398853)	Hepcidin/ferritin ratio ( 27846281) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: ALPI COPS3 CREBBP EP300 HDAC1 IKBKE IRF3 MAVS MYD88 NCOR2 SGTA SIN3A TBK1 TRAF6 TRIM15 TRIM21 XPO1	8 interacting genes: BICD1 HSPB1 IRF5 KRTAP10-3 KRTAP10-8 KRTAP10-9 NOD2 NOTCH2NLA
Entrez ID		3663	248
HPRD ID		06240	01376
Ensembl ID		ENSG00000128604	ENSG00000163295
Uniprot IDs		A0A0G2USB5 B7Z1M2 Q13568	P09923
PDB IDs		3DSH
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Type I Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response Canonical NF-kappaB Signal Transduction Interferon-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Regulation Of Defense Response Defense Response To Virus Innate Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway Response To Virus Antiviral Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-activating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway MRNA Transcription Regulation Of Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Histone H3K27 Acetyltransferase Activity Positive Regulation Of Response To Cytokine Stimulus Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cytokine Production Protein-containing Complex Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cell Communication Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Signaling	Cellular Response To Peptidoglycan Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Muramyl Dipeptide Response To Peptidoglycan Keratin Filament Protein Kinase Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Muramyl Dipeptide Intermediate Filament Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Interleukin-1 Beta Production Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Positive Regulation Of Interleukin-1 Production Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Detection Of Peptidoglycan Regulation Of Notch Signaling Pathway Ubiquitin Binding Regulation Of Interleukin-1 Beta Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Proteinase Activated Receptor Binding Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Protein Kinase C Inhibitor Activity Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Involved In Immune Response Minus-end-directed Organelle Transport Along Microtubule Regulation Of Protein Kinase C Signaling Anion Binding Postsynaptic Endosome Constitutive Secretory Pathway Transport Along Microtubule Positive Regulation Of Protein Localization To Centrosome Secretory Vesicle Virion Assembly Cytoskeleton-dependent Intracellular Transport Regulation Of Tumor Necrosis Factor Production Anterograde Axonal Protein Transport Innate Immune Response-activating Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Pattern Recognition Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Intestinal Stem Cell Homeostasis Protein Linear Polyubiquitination Carbohydrate Derivative Binding
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