IRF5 and IRF3

Number of citations of the paper that reports this interaction (PMID 11303025)
94

Data Source:
HPRD (in vitro, in vivo)

		IRF5	IRF3
Gene Name		interferon regulatory factor 5	interferon regulatory factor 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Regulatory Region DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Transcription, DNA-templated Cytokine-mediated Signaling Pathway Response To Peptidoglycan Response To Muramyl Dipeptide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Response To DNA Damage Stimulus Viral Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Type I Interferon Biosynthetic Process Negative Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Cytokine Secretion Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To DsRNA Macrophage Apoptotic Process Programmed Necrotic Cell Death
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Negative regulators of RIG-I/MDA5 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Interferon gamma signaling Activated TLR4 signalling TRAF3-dependent IRF activation pathway ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN STING mediated induction of host immune responses Interferon alpha/beta signaling Innate Immune System ISG15 antiviral mechanism TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Interferon Signaling Cytokine Signaling in Immune system MyD88-independent cascade Factors involved in megakaryocyte development and platelet production Antiviral mechanism by IFN-stimulated genes Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of innate immune responses to cytosolic DNA Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production TRAF6 mediated IRF7 activation IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS		Primary biliary cirrhosis ( 21399635 20639880) Rheumatoid arthritis ( 20453842) Systemic lupus erythematosus ( 18204446 23273568 23053960 18204098 21408207 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21750679 20383147 21779181) Ulcerative colitis ( 23128233 21297633)
Protein-Protein Interactions		15 interactors: ALPI CREBBP EP300 HDAC1 IKBKE IRF3 MAVS MYD88 NCOR2 SGTA SIN3A TBK1 TRAF6 TRIM15 XPO1	25 interactors: CREBBP EP300 EWSR1 GRIP1 HSP90AA1 IKBKE IRF5 IRF7 MAPK8 MAVS PEX19 PIAS4 PPIB PRDX1 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70A
Entrez ID		3663	3661
HPRD ID		06240	04769
Ensembl ID		ENSG00000128604	ENSG00000126456
Uniprot IDs		Q13568	E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653
PDB IDs		3DSH	1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Regulation Of Cytokine Production Positive Regulation Of Innate Immune Response Positive Regulation Of Cytokine Production Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Innate Immune Response Viral Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 4 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Type I Interferon Production Regulation Of Transcription From RNA Polymerase II Promoter Immune Response Negative Regulation Of Gene Expression Defense Response Positive Regulation Of Immune System Process Type I Interferon Production Regulation Of Signal Transduction Positive Regulation Of Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Interferon-alpha Production Regulation Of Defense Response To Virus Regulation Of Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Transcription, DNA-templated Positive Regulation Of Interferon-beta Production Regulation Of Immune System Process Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Regulation Of RNA Biosynthetic Process Regulation Of Immune Response Negative Regulation Of Biosynthetic Process Response To Stress Regulation Of Cytokine Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Defense Response To Virus By Host	Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Positive Regulation Of Interferon-beta Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Immune Response Regulation Of Innate Immune Response Defense Response Regulation Of Interferon-beta Production Immune Response-regulating Signaling Pathway Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Defense Response To Virus Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Gene Expression Response To Virus Positive Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of Gene Expression I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Response To Other Organism Signaling Response To Bacterium Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Biotic Stimulus Cell Communication Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		ablation bowel ciap colitis cytokine deregulated e3 exacerbates facilitates fate greatly immunity innate ligase limits macrophages mediate proinflammatory proteasome rel signalling tlr tlrs toll traf2 traf3 tumour unexpected upstream	antiviral called cif coactivator composed contain creb cytomegalovirus defense establishes foreskin hcmv immediate interacts interferon interferons intrinsic isg54 latent numerous participate possess responsive shortcut stat stat1 stat2 stimulated tentatively
Tagcloud (Difference) ?		ablation bowel ciap colitis cytokine deregulated e3 exacerbates facilitates fate greatly immunity innate ligase limits macrophages mediate proinflammatory proteasome rel signalling tlr tlrs toll traf2 traf3 tumour unexpected upstream	antiviral called cif coactivator composed contain creb cytomegalovirus defense establishes foreskin hcmv immediate interacts interferon interferons intrinsic isg54 latent numerous participate possess responsive shortcut stat stat1 stat2 stimulated tentatively
Tagcloud (Intersection) ?