IRF5 and TBK1

Number of citations of the paper that reports this interaction (PubMedID 15695821)
0

Data Source:
HPRD (in vivo, in vitro)

		IRF5	TBK1
Description		interferon regulatory factor 5	TANK binding kinase 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleoplasm Cytoplasm Cytosol Serine/threonine Protein Kinase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Sequence-specific DNA Binding Protein Serine/threonine Kinase Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Identical Protein Binding Phosphoprotein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Cellular Response To Virus	Cytoplasmic Translation Activation Of Innate Immune Response Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Phosphorylation Protein Import Into Nucleus Inflammatory Response Canonical NF-kappaB Signal Transduction MRNA Transcription Response To Virus Regulation Of Gene Expression Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Macroautophagy Positive Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway TORC1 Signaling TORC2 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation Defense Response To Gram-positive Bacterium Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway T Follicular Helper Cell Differentiation Defense Response To Other Organism Antiviral Innate Immune Response CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Xenophagy Positive Regulation Of TORC2 Signaling
Pathways		Interferon gamma signaling Interferon alpha/beta signaling SLC15A4:TASL-dependent IRF5 activation	IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN DDX58/IFIH1-mediated induction of interferon-alpha/beta Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN PINK1-PRKN Mediated Mitophagy TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling Interleukin-37 signaling TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Potential therapeutics for SARS SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs			Fostamatinib
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Behcet's disease ( 33393726) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diffuse cutaneous systemic sclerosis ( 29293537) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) Limited cutaneous systemic scleroderma ( 29293537) Liver enzyme levels (alkaline phosphatase) ( 33972514) Primary biliary cholangitis ( 20639880 26394269 21399635) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30423114 24390342 23143596 30572963 21156761) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sjögren's syndrome ( 24097067 28076899) Systemic lupus erythematosus ( 26502338 28714469 32771030 27399966 33272962 26663301 18204098 18204446 19838193 19838195 21408207 23053960 23273568 26606652 24871463) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 24387989 20383147 31672989 21750679 30572963 21779181 30247649 29293537) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Ulcerative colitis ( 23128233 28067908 21297633 26398853)	Amyotrophic lateral sclerosis ( 27455348 29566793) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lung adenocarcinoma ( 28604730) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		17 interacting genes: ALPI COPS3 CREBBP EP300 HDAC1 IKBKE IRF3 MAVS MYD88 NCOR2 SGTA SIN3A TBK1 TRAF6 TRIM15 TRIM21 XPO1	47 interacting genes: AGO2 APP ATG9A AZI2 CDC20 CDC37 CDC42BPG CRTC1 CYLD FZR1 HSP90AA1 HSP90AB1 IKBKB IKBKG IRF3 IRF5 IRF7 LMO7 MAVS MBP MIB2 MTPAP NCK1 NFKBIA PROS1 PTPRD RELA RIPK1 RNF128 RPS6KB1 SIKE1 SMCR8 SMURF1 STX11 TANK TICAM1 TNIP1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRIM21 TXLNG UBC UBQLN2 VHL XIAP
Entrez ID		3663	29110
HPRD ID		06240	05322
Ensembl ID		ENSG00000128604	ENSG00000183735
Uniprot IDs		A0A0G2USB5 B7Z1M2 Q13568	Q9UHD2
PDB IDs		3DSH	4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ 5EOA 5EOF 5EP6 5W5V 6BNY 6BOD 6BOE 6CQ0 6CQ4 6CQ5 6NT9 6O8B 6RSR 6RST 6RSU
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Type I Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response Canonical NF-kappaB Signal Transduction Interferon-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Regulation Of Defense Response Defense Response To Virus Innate Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway Response To Virus Antiviral Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-activating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway MRNA Transcription Regulation Of Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Histone H3K27 Acetyltransferase Activity Positive Regulation Of Response To Cytokine Stimulus Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cytokine Production Protein-containing Complex Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cell Communication Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Signaling	Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Metabolic Process Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Regulation Of Immune Response Regulation Of Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Activation Of Immune Response Immune Response-activating Signaling Pathway Defense Response Regulation Of Protein Metabolic Process Positive Regulation Of Defense Response Positive Regulation Of Innate Immune Response Regulation Of Cell Communication Positive Regulation Of Type I Interferon Production Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Regulation Of Interferon-beta Production Response To Virus Tumor Necrosis Factor-mediated Signaling Pathway Response To External Biotic Stimulus Cytosol Immune Response-regulating Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Other Organism Regulation Of Immune System Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Immune Response Signaling Adaptor Activity Cytoplasm Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cytokine Production Protein Ubiquitination
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