IRF5 and SIN3A

Number of citations of the paper that reports this interaction (PMID 20935208)
14

Data Source:
BioGRID (affinity chromatography technology, pull down)

		IRF5	SIN3A
Gene Name		interferon regulatory factor 5	SIN3 transcription regulator family member A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Kinetochore Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Sin3 Complex Transcriptional Repressor Complex Intercellular Bridge
	Molecular Function	Regulatory Region DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Protein Complex Binding Protein Deacetylase Activity
	Biological Process	Transcription, DNA-templated Cytokine-mediated Signaling Pathway Response To Peptidoglycan Response To Muramyl Dipeptide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Hematopoietic Progenitor Cell Differentiation DNA Replication Transcription, DNA-templated Protein Deacetylation Aging Blood Coagulation Response To Organonitrogen Compound Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Histone Deacetylation Positive Regulation Of Chromatin Silencing Cellular Protein Localization Regulation Of Gene Expression, Epigenetic Negative Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Lipid Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Response To Methylglyoxal Cellular Response To Glucose Stimulus Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Histone H3-K27 Acetylation Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	NoRC negatively regulates rRNA expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Primary biliary cirrhosis ( 21399635 20639880) Rheumatoid arthritis ( 20453842) Systemic lupus erythematosus ( 18204446 23273568 23053960 18204098 21408207 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 21750679 20383147 21779181) Ulcerative colitis ( 23128233 21297633)	Height ( 20189936) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		15 interactors: ALPI CREBBP EP300 HDAC1 IKBKE IRF3 MAVS MYD88 NCOR2 SGTA SIN3A TBK1 TRAF6 TRIM15 XPO1	90 interactors: ARID4A ARID4B BCL6 BCL6B BHLHE40 BRMS1 BRMS1L CBFA2T2 COPS2 CTBP1 CTCF CUL4B DACH1 DDB1 DDX20 DHX30 ETV6 HBP1 HCFC1 HDAC1 HDAC2 HDAC7 HDAC9 HEY2 HIST3H3 HTT IKZF1 IKZF4 ING1 IRF5 KLF10 KLF11 KLF13 KLF16 KLF9 LINC00152 LRCH4 MAD1L1 MBD2 MBD4 MECP2 MEN1 MNT MORF4L2 MXD1 MXD3 MXD4 MXI1 MYB NCOR2 NFKB1 NFKB2 NR2E3 OGT PA2G4 PHB PHF12 PML PRMT5 PTMA RBBP4 RBBP7 RBP1 RBPJ REL RELA RELB RLIM RUNX1T1 SAP18 SAP30 SETDB1 SFPQ SKI SMAD3 SMARCA4 SMARCC1 SMARCE1 SNW1 SPI1 STAT3 SYT1 TAL1 TFCP2 TGIF1 THAP11 TOPORS TP53 TRIM28 ZBTB16
Entrez ID		3663	25942
HPRD ID		06240	09690
Ensembl ID		ENSG00000128604	ENSG00000169375
Uniprot IDs		Q13568	Q96ST3
PDB IDs		3DSH	1PO4
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Regulation Of Cytokine Production Positive Regulation Of Innate Immune Response Positive Regulation Of Cytokine Production Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Innate Immune Response Viral Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 4 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Type I Interferon Production Regulation Of Transcription From RNA Polymerase II Promoter Immune Response Negative Regulation Of Gene Expression Defense Response Positive Regulation Of Immune System Process Type I Interferon Production Regulation Of Signal Transduction Positive Regulation Of Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Interferon-alpha Production Regulation Of Defense Response To Virus Regulation Of Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Transcription, DNA-templated Positive Regulation Of Interferon-beta Production Regulation Of Immune System Process Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Regulation Of RNA Biosynthetic Process Regulation Of Immune Response Negative Regulation Of Biosynthetic Process Response To Stress Regulation Of Cytokine Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Defense Response To Virus By Host	Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Modification Chromosome Organization Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Histone Modification Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Gene Expression, Epigenetic Positive Regulation Of Metabolic Process Regulation Of Cell Proliferation Negative Regulation Of Gene Expression, Epigenetic Organelle Organization Regulation Of Cell Differentiation Regulation Of Chromosome Organization Regulation Of Histone Modification Cell Differentiation
Tagcloud ?		ablation bowel ciap colitis cytokine deregulated e3 exacerbates facilitates fate greatly immunity innate ligase limits macrophages mediate proinflammatory proteasome rel signalling tlr tlrs toll traf2 traf3 tumour unexpected upstream	ablated bcl6 conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Difference) ?		ablation bowel ciap colitis cytokine deregulated e3 exacerbates facilitates fate greatly immunity innate ligase limits macrophages mediate proinflammatory proteasome rel signalling tlr tlrs toll traf2 traf3 tumour unexpected upstream	ablated bcl6 conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Intersection) ?