CXCL8 and ARFGAP3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CXCL8	ARFGAP3
Gene Name		chemokine (C-X-C motif) ligand 8	ADP-ribosylation factor GTPase activating protein 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	Interleukin-8 Receptor Binding Protein Binding Chemokine Activity	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding Protein Transporter Activity
	Biological Process	Angiogenesis Response To Molecule Of Bacterial Origin Movement Of Cell Or Subcellular Component Chemotaxis Inflammatory Response Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Endoplasmic Reticulum Unfolded Protein Response Receptor Internalization Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis	Intracellular Protein Transport Protein Secretion Vesicle-mediated Transport Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Cellular Senescence ATF4 activates genes Senescence-Associated Secretory Phenotype (SASP) GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ACKR1 ARFGAP3 BAG6 CCL4 CCL5 CSNK2A1 CTSL CXCR1 CXCR2 EP300 GNAI2 IL12A MMP9 PF4 POMGNT1 SDC1 SGTA WASF1	5 interactors: APP CD14 CXCL8 SMAD2 ZDHHC17
Entrez ID		3576	26286
HPRD ID		00909	06444
Ensembl ID		ENSG00000169429	ENSG00000242247
Uniprot IDs		P10145	C9JZR4 Q9NP61
PDB IDs		1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8	2CRW
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Defense Response Inflammatory Response Signal Transduction Cell Chemotaxis Dendritic Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Signaling Response To External Stimulus Cell Communication Movement Of Cell Or Subcellular Component Positive Regulation Of Leukocyte Migration Leukocyte Migration Interleukin-8-mediated Signaling Pathway Response To Stress Immune System Process Dendritic Cell Migration Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cell Migration Cellular Response To Stimulus Locomotion Interaction With Symbiont Positive Regulation Of Behavior Cell Motility Cell Surface Receptor Signaling Pathway Regulation Of Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Behavior Cytokine-mediated Signaling Pathway Regulation Of Viral Transcription Immune Response Response To Stimulus Negative Regulation By Host Of Viral Transcription Response To Organic Substance Positive Regulation Of Immune System Process Regulation Of Apoptotic Process Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Regulation Of Cell Proliferation Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Cell Death Regulation Of Cell Motility Regulation Of Locomotion	Endocytosis Response To Tumor Necrosis Factor Digestive Tract Development Digestive System Development Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Synaptic Growth At Neuromuscular Junction Cellular Response To Lipopolysaccharide Transport Response To Lipid Cellular Response To Molecule Of Bacterial Origin Signal Transduction Collateral Sprouting In Absence Of Injury Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Signaling Cell Communication Regulation Of Signal Transduction Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Mesoderm Development Primary MiRNA Processing Regulation Of Signaling Developmental Growth Axon Choice Point Recognition Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Cell Surface Receptor Signaling Pathway Immune Response Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response Response To Lipopolysaccharide Cellular Response To Stimulus Response To Molecule Of Bacterial Origin Neuron Remodeling Vesicle-mediated Transport SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Cellular Response To Lipoteichoic Acid Cellular Response To Lipid Inflammatory Response Nodal Signaling Pathway Response To Magnesium Ion Posttranscriptional Regulation Of Gene Expression Induction Of Positive Chemotaxis Cellular Copper Ion Homeostasis Response To Bacterium Embryonic Organ Development
Tagcloud ?			accelerated adaptors adp associates cargo cathepsin cation cimpr clathrin copi ear endosomes exit explaining gga ggas golgi mannose perturbed rescued retrograde ribosylation slowed sorting traffic
Tagcloud (Difference) ?			accelerated adaptors adp associates cargo cathepsin cation cimpr clathrin copi ear endosomes exit explaining gga ggas golgi mannose perturbed rescued retrograde ribosylation slowed sorting traffic
Tagcloud (Intersection) ?