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CXCL8 and ARFGAP3
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
CXCL8
ARFGAP3
Gene Name
chemokine (C-X-C motif) ligand 8
ADP-ribosylation factor GTPase activating protein 3
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Golgi Membrane
Cytoplasm
Golgi Apparatus
Cytosol
Membrane
Molecular Function
Interleukin-8 Receptor Binding
Protein Binding
Chemokine Activity
Protein Binding
ARF GTPase Activator Activity
Zinc Ion Binding
Protein Transporter Activity
Biological Process
Angiogenesis
Response To Molecule Of Bacterial Origin
Movement Of Cell Or Subcellular Component
Chemotaxis
Inflammatory Response
Immune Response
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Cell Cycle Arrest
Signal Transduction
G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of Cell Proliferation
Calcium-mediated Signaling
Regulation Of Cell Adhesion
Neutrophil Chemotaxis
Endoplasmic Reticulum Unfolded Protein Response
Receptor Internalization
Response To Endoplasmic Reticulum Stress
Intracellular Signal Transduction
Neutrophil Activation
Cellular Protein Metabolic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Embryonic Digestive Tract Development
Induction Of Positive Chemotaxis
Chemokine-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Neutrophil Chemotaxis
Intracellular Protein Transport
Protein Secretion
Vesicle-mediated Transport
Regulation Of ARF GTPase Activity
Positive Regulation Of GTPase Activity
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
Class A/1 (Rhodopsin-like receptors)
Cellular Senescence
ATF4 activates genes
Senescence-Associated Secretory Phenotype (SASP)
GPCR ligand binding
Metabolic disorders of biological oxidation enzymes
GPCR downstream signaling
Peptide ligand-binding receptors
Chemokine receptors bind chemokines
G alpha (i) signalling events
PERK regulates gene expression
Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions
18 interactors:
ACKR1
ARFGAP3
BAG6
CCL4
CCL5
CSNK2A1
CTSL
CXCR1
CXCR2
EP300
GNAI2
IL12A
MMP9
PF4
POMGNT1
SDC1
SGTA
WASF1
5 interactors:
APP
CD14
CXCL8
SMAD2
ZDHHC17
Entrez ID
3576
26286
HPRD ID
00909
06444
Ensembl ID
ENSG00000169429
ENSG00000242247
Uniprot IDs
P10145
C9JZR4
Q9NP61
PDB IDs
1ICW
1IKL
1IKM
1IL8
1ILP
1ILQ
1QE6
1ROD
2IL8
3IL8
2CRW
Enriched GO Terms of Interacting Partners
?
Chemokine-mediated Signaling Pathway
Defense Response
Inflammatory Response
Signal Transduction
Cell Chemotaxis
Dendritic Cell Chemotaxis
Positive Regulation Of Leukocyte Chemotaxis
Chemotaxis
Signaling
Response To External Stimulus
Cell Communication
Movement Of Cell Or Subcellular Component
Positive Regulation Of Leukocyte Migration
Leukocyte Migration
Interleukin-8-mediated Signaling Pathway
Response To Stress
Immune System Process
Dendritic Cell Migration
Leukocyte Chemotaxis
Positive Regulation Of Chemotaxis
Regulation Of Leukocyte Migration
Cell Migration
Cellular Response To Stimulus
Locomotion
Interaction With Symbiont
Positive Regulation Of Behavior
Cell Motility
Cell Surface Receptor Signaling Pathway
Regulation Of Chemotaxis
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Cellular Component Movement
Positive Regulation Of Locomotion
Positive Regulation Of Natural Killer Cell Chemotaxis
Regulation Of Behavior
Cytokine-mediated Signaling Pathway
Regulation Of Viral Transcription
Immune Response
Response To Stimulus
Negative Regulation By Host Of Viral Transcription
Response To Organic Substance
Positive Regulation Of Immune System Process
Regulation Of Apoptotic Process
Cellular Response To Cytokine Stimulus
Regulation Of Cell Migration
Regulation Of Cell Proliferation
Negative Regulation Of Myeloid Cell Apoptotic Process
Regulation Of Cell Death
Regulation Of Cell Motility
Regulation Of Locomotion
Endocytosis
Response To Tumor Necrosis Factor
Digestive Tract Development
Digestive System Development
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Synaptic Growth At Neuromuscular Junction
Cellular Response To Lipopolysaccharide
Transport
Response To Lipid
Cellular Response To Molecule Of Bacterial Origin
Signal Transduction
Collateral Sprouting In Absence Of Injury
Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Zygotic Specification Of Dorsal/ventral Axis
Signaling
Cell Communication
Regulation Of Signal Transduction
Collateral Sprouting
Axon Midline Choice Point Recognition
Regulation Of Binding
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Positive Regulation Of Mesoderm Development
Primary MiRNA Processing
Regulation Of Signaling
Developmental Growth
Axon Choice Point Recognition
Regulation Of Nodal Signaling Pathway
Common-partner SMAD Protein Phosphorylation
Cell Surface Receptor Signaling Pathway
Immune Response
Positive Regulation Of Activin Receptor Signaling Pathway
Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Defense Response
Response To Lipopolysaccharide
Cellular Response To Stimulus
Response To Molecule Of Bacterial Origin
Neuron Remodeling
Vesicle-mediated Transport
SMAD Protein Complex Assembly
Paraxial Mesoderm Morphogenesis
Cellular Response To Lipoteichoic Acid
Cellular Response To Lipid
Inflammatory Response
Nodal Signaling Pathway
Response To Magnesium Ion
Posttranscriptional Regulation Of Gene Expression
Induction Of Positive Chemotaxis
Cellular Copper Ion Homeostasis
Response To Bacterium
Embryonic Organ Development
Tagcloud
?
accelerated
adaptors
adp
associates
cargo
cathepsin
cation
cimpr
clathrin
copi
ear
endosomes
exit
explaining
gga
ggas
golgi
mannose
perturbed
rescued
retrograde
ribosylation
slowed
sorting
traffic
Tagcloud (Difference)
?
accelerated
adaptors
adp
associates
cargo
cathepsin
cation
cimpr
clathrin
copi
ear
endosomes
exit
explaining
gga
ggas
golgi
mannose
perturbed
rescued
retrograde
ribosylation
slowed
sorting
traffic
Tagcloud (Intersection)
?