CXCL8 and CTSL

Number of citations of the paper that reports this interaction (PMID 12818188)
3

Data Source:
HPRD (in vitro)

		CXCL8	CTSL
Gene Name		chemokine (C-X-C motif) ligand 8	cathepsin L
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Nucleus Lysosome Endolysosome Lumen Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Interleukin-8 Receptor Binding Protein Binding Chemokine Activity	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding
	Biological Process	Angiogenesis Response To Molecule Of Bacterial Origin Movement Of Cell Or Subcellular Component Chemotaxis Inflammatory Response Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Endoplasmic Reticulum Unfolded Protein Response Receptor Internalization Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis	Toll-like Receptor Signaling Pathway Adaptive Immune Response Proteolysis Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Cellular Senescence ATF4 activates genes Senescence-Associated Secretory Phenotype (SASP) GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events PERK regulates gene expression Unfolded Protein Response (UPR)	Collagen formation Collagen degradation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades MHC class II antigen presentation Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ACKR1 ARFGAP3 BAG6 CCL4 CCL5 CSNK2A1 CTSL CXCR1 CXCR2 EP300 GNAI2 IL12A MMP9 PF4 POMGNT1 SDC1 SGTA WASF1	27 interactors: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG
Entrez ID		3576	1514
HPRD ID		00909	00293
Ensembl ID		ENSG00000169429	ENSG00000135047
Uniprot IDs		P10145	P07711 Q9HBQ7
PDB IDs		1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8	1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Defense Response Inflammatory Response Signal Transduction Cell Chemotaxis Dendritic Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Signaling Response To External Stimulus Cell Communication Movement Of Cell Or Subcellular Component Positive Regulation Of Leukocyte Migration Leukocyte Migration Interleukin-8-mediated Signaling Pathway Response To Stress Immune System Process Dendritic Cell Migration Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cell Migration Cellular Response To Stimulus Locomotion Interaction With Symbiont Positive Regulation Of Behavior Cell Motility Cell Surface Receptor Signaling Pathway Regulation Of Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Behavior Cytokine-mediated Signaling Pathway Regulation Of Viral Transcription Immune Response Response To Stimulus Negative Regulation By Host Of Viral Transcription Response To Organic Substance Positive Regulation Of Immune System Process Regulation Of Apoptotic Process Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Regulation Of Cell Proliferation Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Cell Death Regulation Of Cell Motility Regulation Of Locomotion	Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrolase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Protein Insertion Into ER Membrane Immune Response Regulation Of Apoptotic Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Cell Death Adaptive Immune Response Protein Insertion Into Membrane Positive Regulation Of Neutrophil Chemotaxis Immune System Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Cell Migration Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Regulation Of Cell Motility T Cell Mediated Immunity Regulation Of Granulocyte Chemotaxis Regulation Of Locomotion Cell Activation Positive Regulation Of Histone Methylation Regulation Of Cellular Component Movement Response To Abiotic Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Endoplasmic Reticulum Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Methylation Negative Regulation Of Blood Coagulation
Tagcloud ?			a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored
Tagcloud (Difference) ?			a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored
Tagcloud (Intersection) ?