CXCL8 and ZNF598

Number of citations of the paper that reports this interaction (PubMedID 30917308)
0

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		CXCL8	ZNF598
Description		C-X-C motif chemokine ligand 8	zinc finger protein 598, E3 ubiquitin ligase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Cytosol Cytosolic Ribosome
	Molecular Function	Cytokine Activity Interleukin-8 Receptor Binding Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Ribosome Binding Metal Ion Binding Ubiquitin-protein Transferase Regulator Activity Ubiquitin Protein Ligase Activity Protein-RNA Adaptor Activity Stalled Ribosome Sensor Activity
	Biological Process	Angiogenesis Response To Molecule Of Bacterial Origin Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Receptor Internalization Killing Of Cells Of Another Organism Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Negative Regulation Of Cell Adhesion Molecule Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Regulation Of Entry Of Bacterium Into Host Cell	Regulation Of Translation Protein Monoubiquitination Protein Ubiquitination Ribosome Disassembly Negative Regulation Of Translational Initiation Protein K63-linked Ubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		ABT-510 MDX-018 Rivanicline Oleandrin
Diseases
GWAS		Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566)
Interacting Genes		23 interacting genes: ACKR1 ARFGAP3 BAG6 CCL2 CCL4 CCL5 CCL8 CTSL CXCR1 CXCR2 EP300 ERBB2 GNAI2 IL12A MMP14 MMP9 PF4 POMGNT1 SDC1 SGTA WASF1 ZFP36 ZNF598	8 interacting genes: CDA CXCL8 DBN1 RPS10 RPS20 RPS3 UBE2D1 UBE2D3
Entrez ID		3576	90850
HPRD ID		00909	11732
Ensembl ID		ENSG00000169429	ENSG00000167962
Uniprot IDs		C9J4T6 P10145	A0AAG2UWE8 Q86UK7
PDB IDs		1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ 6LFM 6LFO 6N2U 6WZM 6XMN 8IC0 8XWN 8XX6
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Granulocyte Migration Cell Surface Receptor Signaling Pathway Myeloid Leukocyte Migration Leukocyte Chemotaxis Cytokine-mediated Signaling Pathway Cell Migration Chemokine Activity Cell Chemotaxis Locomotion Eosinophil Chemotaxis Leukocyte Migration Eosinophil Migration C-C Chemokine Binding Cell Motility Positive Regulation Of Leukocyte Migration CCR Chemokine Receptor Binding Signal Transduction Chemotaxis Positive Regulation Of Mononuclear Cell Migration Inflammatory Response Mononuclear Cell Migration Cytokine Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Response To Stress Immune System Process Regulation Of Mononuclear Cell Migration Dendritic Cell Chemotaxis Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Regulation Of Immune System Process Antimicrobial Humoral Response Receptor-mediated Endocytosis Host-mediated Perturbation Of Viral Process Positive Regulation Of Immune System Process Monocyte Chemotaxis Defense Response Dendritic Cell Migration Regulation Of Lymphocyte Chemotaxis Interleukin-8 Binding Positive Regulation Of Macrophage Migration Regulation Of Apoptotic Process Positive Regulation Of Leukocyte Chemotaxis Host-mediated Perturbation Of Viral Transcription	Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Small Ribosomal Subunit Ribosome Ubiquitin Conjugating Enzyme Activity Regulation Of Cell Communication Regulation Of Signaling Response To TNF Agonist Oxidized Pyrimidine DNA Binding Negative Regulation Of BMP Signaling Pathway Translation Cellular Response To External Biotic Stimulus Cytosine Metabolic Process Cell Communication By Chemical Coupling Interleukin-8 Receptor Binding Positive Regulation Of Base-excision Repair Ribonucleoprotein Complex Cellular Response To Tumor Necrosis Factor Nucleoside Binding Regulation Of Signal Transduction Positive Regulation Of Endodeoxyribonuclease Activity Protein K48-linked Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Receptor Localization To Synapse Response To Tumor Necrosis Factor Positive Regulation Of Deoxyribonuclease Activity NF-kappaB Complex Regulation Of Base-excision Repair Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Cycloheximide Negative Regulation Of Macromolecule Biosynthetic Process UMP Salvage Pyrimidine Ribonucleotide Salvage Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Biosynthetic Process Oxidized Purine DNA Binding Regulation Of Endodeoxyribonuclease Activity Ubiquitin-like Protein Conjugating Enzyme Binding Supercoiled DNA Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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