CXCL8 and SDC1

Number of citations of the paper that reports this interaction (PMID 12902511)
16

Data Source:
HPRD (in vitro)

		CXCL8	SDC1
Gene Name		chemokine (C-X-C motif) ligand 8	syndecan 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Lysosomal Lumen Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Interleukin-8 Receptor Binding Protein Binding Chemokine Activity	Glycoprotein Binding Protein Binding Protein C-terminus Binding
	Biological Process	Angiogenesis Response To Molecule Of Bacterial Origin Movement Of Cell Or Subcellular Component Chemotaxis Inflammatory Response Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Endoplasmic Reticulum Unfolded Protein Response Receptor Internalization Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis	Retinoid Metabolic Process Ureteric Bud Development Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Inflammatory Response Phototransduction, Visible Light Pathogenesis Response To Toxic Substance Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Wound Healing Lipoprotein Metabolic Process Odontogenesis Response To Hydrogen Peroxide Small Molecule Metabolic Process Myoblast Development Response To Glucocorticoid Response To CAMP Response To Calcium Ion Striated Muscle Cell Development Sertoli Cell Development Canonical Wnt Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Vesicular Exosome Assembly
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Cellular Senescence ATF4 activates genes Senescence-Associated Secretory Phenotype (SASP) GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events PERK regulates gene expression Unfolded Protein Response (UPR)	Lipoprotein metabolism MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Metabolism of lipids and lipoproteins Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chylomicron-mediated lipid transport Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Lipid digestion, mobilization, and transport Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Syndecan interactions Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ACKR1 ARFGAP3 BAG6 CCL4 CCL5 CSNK2A1 CTSL CXCR1 CXCR2 EP300 GNAI2 IL12A MMP9 PF4 POMGNT1 SDC1 SGTA WASF1	15 interactors: APP CASK CCL5 CD63 CTSG CXCL8 ELANE FGF2 HGF IGFBP7 LACRT MDK MMP14 PTN SDCBP
Entrez ID		3576	6382
HPRD ID		00909	01718
Ensembl ID		ENSG00000169429	ENSG00000115884
Uniprot IDs		P10145	P18827
PDB IDs		1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8	4GVC 4GVD
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Defense Response Inflammatory Response Signal Transduction Cell Chemotaxis Dendritic Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Signaling Response To External Stimulus Cell Communication Movement Of Cell Or Subcellular Component Positive Regulation Of Leukocyte Migration Leukocyte Migration Interleukin-8-mediated Signaling Pathway Response To Stress Immune System Process Dendritic Cell Migration Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cell Migration Cellular Response To Stimulus Locomotion Interaction With Symbiont Positive Regulation Of Behavior Cell Motility Cell Surface Receptor Signaling Pathway Regulation Of Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Behavior Cytokine-mediated Signaling Pathway Regulation Of Viral Transcription Immune Response Response To Stimulus Negative Regulation By Host Of Viral Transcription Response To Organic Substance Positive Regulation Of Immune System Process Regulation Of Apoptotic Process Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Regulation Of Cell Proliferation Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Cell Death Regulation Of Cell Motility Regulation Of Locomotion	Cell Migration Locomotion Cell Motility Positive Regulation Of Cellular Metabolic Process Movement Of Cell Or Subcellular Component Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Behavior Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Lipid Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Response To Stress Positive Chemotaxis Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Chemotaxis Interaction With Symbiont Regulation Of Growth Positive Regulation Of Cell Migration Regulation Of Protein Metabolic Process Regulation Of Chemotaxis Positive Regulation Of Cell Motility Secretion Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Locomotion Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus Response To Organic Substance Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Defense Response Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Killing By Host Of Symbiont Cells Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Platelet Degranulation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Organ Development Regulation Of Body Fluid Levels
Tagcloud ?			alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc4 shares spreading syndecan syndecans utilized
Tagcloud (Difference) ?			alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc4 shares spreading syndecan syndecans utilized
Tagcloud (Intersection) ?